Yintoni i Anandamide (AEA)

Anandamide (AEA), Ikwabizwa ngokuba yimolekyuli yolonwabo, okanye N-arachidonoylethanolamine (AEA), yi-fatty acid neurotransmitter. Igama elithi Anadamida (AEA) lithathwe kwiSanskrit Yovuyo "Ananda." URafael Mechoulam waqulunqa eli xesha. Njani, kunye nabancedisi bakhe ababini, u-WA Devane kunye noLumír Hanuš, baqala ukufumanisa i- "Anandamide" ngo-1992. 

 

Isebenza njani iAnandamide (AEA)

I-Anandamide (AEA) ithathwe kwimetabolism engeyiyo-oxidative ye-eicosatetraenoic acid. I-Anandamide (AEA) ngumlamli we-lipid kunye nemisebenzi njenge-endo native ligand ye-CB1 receptors kwaye imodareyitha umvuzo wayo wesekethe. I-neurotransmitter ebalulekileyo kwinkqubo ye-endocannabinoid, ethiywe ngegama le-Cannabis. Inceda ukulawula ukuhamba kweenkqubo ze-neurochemical ukugcina umzimba kunye nengqondo yakho isebenza kakuhle. Kufunyenwe ukuba ubume be-Anandamide bufana ne-tetrahydrocannabinol (THC), eyona nto iphambili kwi-Cannabis. Yiyo loo nto iAnandamide itshintsha imo ifanisa into eyaziwa ngokuba yi-Cannabis ephezulu.

Imvelo iveliswa emzimbeni wethu ngokomyalelo wobuchopho ngokuphendula kwe-condensation kwii-neurons. Impendulo ye-condensation elawulwa yi-calcium ion kunye ne-cyclic monophosphate adenosine yenzeka phakathi kwe-arachidonic acid kunye ne-ethanolamine. 

I-Anandamide yonyusa ulonwabo ngokudibana ne-cannabinoid receptors kwinkqubo ye-nervous and peripheral system, CB1 kunye ne-CB2. Ii-receptors ze-CB1 zijolise ekuqhubeni iimoto (ukuhamba) kunye nokulungelelanisa, ukucinga, ukutya, imemori yamagama amafutshane, ukuqonda iintlungu kunye nokungakhuseleki. Kwangelo xesha, ii-receptors ze-CB2 zijolise kumalungu aphambili afana neLiver, Gut, kidney, Pancreas, izicubu zeAdipose, umsipha wamathambo, ithambo, iliso, amathumba, inkqubo yokuzala, inkqubo yokuzikhusela komzimba, indlela yokuphefumla, ulusu, inkqubo yovalo oluPhakathi, kunye nenkqubo yentliziyo. .

Emizimbeni yethu, i-N-arachidonoylethanolamine yehla ibe yi-fatty acid amide hydrolase (FAAH) enzyme kwaye ivelise i-arachidonic acid kunye ne-ethanolamine. Ukuba isenzo se-FAAH sika-FAAH sinokucothiswa, sinokuvuna izibonelelo zika-Anandamide's Anandamide ixesha elide.

Anandamide (AEA)

Izibonelelo ze-Anandamide (AEA)

I-Anandamide (AEA) ilinganisa iziphumo ze-Cannabis kwinkqubo yethu, ngaphandle kwemiphumo emibi. I-Anandamide isinceda ngokukhuthaza ukusebenza kwengqondo yethu kwezi ndlela zilandelayo:

  1. Ukuphucula amandla engqondo kunye nenkumbulo

Ukuphucula amandla akho ememori yokusebenza yeyona nto iphambili Izibonelelo ze-Anandamide (AEA). Inokukunceda ukuba ube nobuchule ngakumbi ngokuqhubekeka ngolwazi kwiimbono ezintsha. Isifundo kwiimpuku sibonakalise ukuphucuka okubonakalayo ekusebenzeni kwengqondo. Ke ukuba ufuna ukuphucula izakhono zakho zohlalutyo, izakhono zokuyila, okanye wenze kakuhle kwizifundo zakho, iAnandamide sisisombululo esifanelekileyo.

  1. Isebenza njengomlawuli wokutya

Ukuba ufuna ukulandela ukutya okungqongqo, ulawulo lokutya kufuneka. Enye yezibonelelo zeAnandamide ngaba inokukunceda ulawule ukutya kunye nokujikeleza komzimba. Unokulawula ngokulula inimba yendlala okanye iminqweno ye-junk ngoncedo lwe-Anandamide. Ngale ndlela, unokufezekisa iithagethi zakho zokulahleka kobunzima okanye iithagethi zokufumana kwakhona imilo. Kwiintsuku zanamhlanje ukuhlala usempilweni kwaye ulungile ubukhulu becala kuxhomekeke kwimikhwa yethu yokutya, kwaye izongezo zeAnandamide zinokusinceda. Kodwa izicwangciso zokulahleka kwesisindo kunye neAnandamide kufuneka zincedisane nezicwangciso ezifanelekileyo zokutya. Ukuyekisa okungaphantsi kunokukhokelela ekulahlekelweni ngesiquphe kobunzima bomzimba kwaye, ngenxa yoko, iingxaki zomzimba. Kwimeko yoomama abancancisayo, ukusetyenziswa kwe-Anandamide kufuneka kuthintelwe.

  1. I-Neurogeneis

Enye indlela yokwandisa amandla akho okusebenza kwengqondo kukuba uneeseli ezintsha okanye iiseli zengqondo ngeNeurogenesis. Oku kuyinyani, ngakumbi usondele kwi-40 okanye uhambe ngaphaya kweminyaka. I-Anandamide (AEA) iyanceda kwi-Neurogenesis.

Ngapha koko, amanqanaba aphezulu amanqanaba e-Anandamide emzimbeni womntu aphelisa umngcipheko wezifo ze-neurodeergenerative ezinje ngesifo sikaPerkinson'sPerkinson, njl. Umzimba, njl. I-Anandamide (AEA) inceda abantu abadala ukuba babonwabele ubomi babo bokuthatha umhlala-phantsi ngaphandle kokukhathazeka ngemicimbi yabo yezempilo.

  1. Ukulawula iminqweno yesini

I-Anandamide (AEA) izibonelelo zokulawula umnqweno wakho wesondo ngeendlela ezimbini. Kwidosi encinci, inyusa iminqweno yesini. Kodwa ngethamo elinzima le-Anandamide (AEA) kunciphisa umnqweno wesini. I-Anandamide (AEA) iphucula imeko yakho yeemvakalelo kwaye inciphise uxinzelelo olunikezela isini. Kodwa idosi ephezulu ikwenza wanelise ngokwesondo, kwaye awufumani sidingo sokwabelana ngesondo.

  1. Iipropathi ezichasene noMhlaza

I-Anandamide (AEA) ineepropathi ze-carcinogenic ye-carcinogenic ngenxa yeempembelelo zengqondo. I-Anandamide (AEA) ilwa nokukhula kwezicubu zomhlaza. Iluncedo ngakumbi kumhlaza wamabele. Amalinge abonisa ukuba inokuba yindawo efanelekileyo yokubuyisela iziyobisi eziqhelekileyo kumhlaza. Ngapha koko, isimahla nakweyiphi na imiphumela esecaleni xa kuthelekiswa neziphumo zokutshintsha kobomi zeziyobisi zomhlaza oqhelekileyo. Kungekudala, ukwamkelwa okukhulu kwe-Anandamide (AEA) kunokunciphisa iintlungu abaguli abanomhlaza abadlula kuzo ngexesha lonyango. 

  1. Iipropati ze-antiemetic

Isihlunu kunye nokuhlanza kunokulawulwa kunye ne-Anandamide (AEA). Isebenza nge-serotonin ukulawula isicaphucaphu. Oku kwenza i-Anandamide (AEA) isisombululo se-antiemetic ngexesha le-chemotherapy kwizigulana ezinomhlaza. Oku kunokuba kuhle koomama abakhulelweyo. Kodwa kwimeko yoomama abakhulelweyo, iAnandamide (AEA) kufuneka yenziwe kuphela xa icetyiswa ngugqirha wakhe.

  1. Iipropathi zokunceda iintlungu

Ngokudibana ne-CB1, i-Anandamide (AEA) ibhloka ukuhanjiswa kweempawu zentlungu. Ngale ndlela, iAnandamide (AEA) inokusetyenziselwa ukuphelisa iintlungu ezingapheliyo kwizigulana ezinengxaki yezonyango ezifana ne-gout, i-arthritis, okanye i-sciatica. Kudala, iintlungu zihlala zihleli. I-Anandamide (AEA) sisixhobo esingqiniweyo se-migraines kunye nezinye iintloko ezibi kakhulu. Ukusetyenziswa kwe-Anandamide (AEA) izongezo ekwaluphaleni kunokubanceda boyise iintlungu kwaye kuya kuphucula nobomi babo.

  1. Umlawuli weMood

Inkqubo ye-endocannabinoid ilawula imood yethu. I-Anandamide (AEA) ilawula iingqondo zethu ezingalunganga njengoloyiko, unxunguphalo, kunye nokonyusa ulonwabo. Ngale ndlela, iAnandamide (AEA) inokusebenza njengesixhobo sokuphakamisa imo, ukuphucula impilo yengqondo, kunye nokuphucula imeko yakho yangaphakathi. Njengoko i-Anandamide (AEA) izongezo zingalunganga, kuyacetyiswa kakhulu, ngakumbi kubemi abaneminyaka yokusebenza, ekufuneka baqhubeke nokusebenza ngemveliso ephezulu kwindawo enzima kakhulu kunye noxinzelelo.

  1. Ukulwa nokudakumba

I-Anandamide (AEA) nayo inokulwa ukudangala. Uphononongo lweempuku kutshanje lubonakalise iipropathi zoxinzelelo. Uxinzelelo kunye neengxaki ezinxulumene nazo zithatha impilo yethu yengqondo neyomzimba… nakwindawo esihlala kuyo. Ukuba likhoboka le-nicotine, utywala, ukusetyenziswa gwenxa kweziyobisi kuhlala kunxulunyaniswa nokudakumba. Iimeko ezibi nangakumbi zinokukhokelela ekubeni abantu bathathe ubomi babo. Ukudakumba kunokuba yinto ebuthathaka engakhokelela nasekufeni kwabantu. I-Anandamide (AEA) inokuba sisisombululo esikhulu kule ngxaki.

  1. Ukulwa nokuvuvukala kunye ne-Edema

I-Anandamide (AEA) inciphisa ukudumba kweseli kunye nokudumba. Ngale ndlela, ikwaluncedo njengesisombululo esichasayo.

  1. Iphucula ukuchuma

I-Anandamide (AEA) inokudlala indima eluncedo ekuvuseleleni nasekumiliseleni. Izifundo zibonisa ukuba amanqanaba aphezulu e-Anandamide (AEA) aqinisekisa ukuphumelela kwe-ovulation.

  1. Isombulula uxinzelelo lwehyper-Tension kunye nezintso

Ngaphezulu kwe-60% yabantu baya kuphuhlisa uxinzelelo lwegazi okanye izifo ezinganyangekiyo zezintso. I-Anandamide (AEA) inokuguqula imisebenzi yezintso ebangela isifo. I-Anandamide (AEA) ibonise iziphumo ezilungileyo ekusombululeni iingxaki ezibangelwa luxinzelelo lwegazi oluphakamileyo. 

 

Imithombo yendalo iAnandamide (AEA)

  • I-Acids Fatty Acids

Amaqanda, imbewu yeChia, imbewu yeflakisi, isardadi, imbewu ye-hemp yimithombo emihle ye-endocannabinoid eyonyusa amanqatha e-asidi. Kananjalo, oku kuphucula inqanaba le-Omega 3 kunye ne-Omega 6 emzimbeni wethu ukuphucula umsebenzi we-endocannabinoid.

  • Iti kunye neeHerbs

I-Cannabis, i-clove, i-sinamoni, i-pepper emnyama, i-oregano, njl. Ukuphucula amanqanaba e-Anandamide kwimizimba yethu. Iti ngumthombo olunge kakhulu weAnandamide (AEA).

  • Tshokolethi

Itshokholethi emnyama yenye yezona mithombo zibalaseleyo zeAnandamide. I-cocoa powder yenziwe nge-oleolethanolamine kunye ne-linoleoylethanolamine. Ukunciphisa ukuhla kwe-endocannabinoids kwaye ngoko kugcina amanqanaba e-Anandamide emzimbeni wethu. Kwakhona, itshokholethi ine-theobromine, enceda imveliso yeAnandamide.

  • I-Truffles emnyama (ifungi emnyama)

I-Truffles emnyama iqulethe i-Anandamide yendalo.

 

Anandamide (AEA) izongezo kunye nezinye iindlela zokuphucula amanqanaba eAnandamide

  • CBD (Cannabidiol)

Enye yeendlela ezilungileyo zokukhuthaza inkqubo ye-endocannabinoid kukusetyenziswa kwe-CBD. I-CBD ngowona mthombo uphambili wentsangu yezonyango. I-CBD inqanda i-FAAH kwaye ke iphucula amanqanaba e-Anandamide emzimbeni wethu. 

  • Lolonga

Ukuzilolonga kuzisa into entle kuthi. Ukuzivocavoca kuphucula amanqanaba e-Anandamide emzimbeni kwaye ke ukwandisa ukwanda kwakho kokuzivocavoca nzima. Uvavanyo lubonisa ukuba emva kokuzilolonga, baye bazole kwaye bangabinazintlungu. Oku kufanelekile ngenxa ye-CB1 kunye ne-CB2'sCB2's activation ngu-Anandamide. Iyabonakala imizuzu engama-30 yokubaleka ngamandla okanye i-aerobics inyusa kakhulu amanqanaba e-Anandamide kwimizimba yethu. Kukwabonwa ukuba imigraines yezigulana ezithatha i-aerobics zihlala zichacha ngokufanayo. Ngokukodwa kungenxa yamanqanaba aphezulu e-Anandamide aveliswe emzimbeni wabo ngenxa yomthambo onzima.

  • Ukunciphisa uxinzelelo

Abantu abanokulawula uxinzelelo banenqanaba eliphezulu le-Anandamide kubo. Uxinzelelo luyanciphisa ukusebenza kwe-CB1 kwaye ngenxa yoko kunciphisa amanqanaba e-Anandamide kwaye, nawo, abonise ukunciphisa ukusebenza kwe-cannabinoid. Yiphephe ke imeko yoxinzelelo ukuphucula impilo yonke. Esinye sezisombululo kukucamngca.

Ukulamla kuphucula amanqanaba e-Anandamide kunye ne-dopamine emzimbeni wethu. I-Mediatbodiesleads ikhokelela kumanqanaba aphezulu e-oxytocin ekonyusa amanqanaba e-Anandamide emzimbeni wethu. Kufana nomjikelo olungileyo wentlalo. I-Anandamide ikunceda ukuba wehlise umoya kwaye ucamngce; Ukucamngca kuqhubela phambili kuphucula amanqanaba akho e-Anandamide kwaye kukunceda ufumane isiqabu kuxinzelelo.

Anandamide (AEA)

 

I-Anandamide (AEA) Isisombululo

Njengazo ezinye i-endocannabinoids, idosi engaphantsi yeAnandamide ilungile kuthi. Amanani aphezulu ayingozi kwimizimba yethu. 1.0mg / kg. (ubunzima bomzimba ngamnye (i-Kg nganye) kufanelekile idosi yeAnandamide (AEA). Kodwa ukuba ufumana naziphi na iingxaki, kufuneka ubonane nogqirha ngokukhawuleza. Koomama abakhulelweyo kunye noomama abancancisayo kufuneka babonane noogqirha babo ngaphambi kokuba kusetyenziswe iAnandamide (AEA). 

 

I-Anandamide (AEA) Iziphumo ebezingalindelekanga

I-Anandamide inokunyamezelana okuphezulu kunye neziphumo ebezingalindelekanga ezisezantsi. Unokufumana ubunzima bokwexeshana njengokulahleka kwesisindo, isiyezi, okanye ukugabha. Kwiimeko ezithile, ulawulo lwe-Anandamide (AEA) ngexesha lokuncancisa (kufundwe kwiimpuku zabantu abadala) kukhokelela ekuzuzeni ubunzima, ekuqokeleleni amafutha emzimbeni, nakwi-insulin. Oku kwenzeka ngenxa yokwanda komnqweno okhokelela kukutya okuphezulu.

 

ukuthenga  Anandamide (AEA) Izixhobo

Singakuqonda ngokulula ukuphila ubomi obunempilo i-Anandamide (AEA) kubalulekile. Inceda ekuthinteleni nasekulweni izifo ezahlukeneyo. Ukuthintela ukusilela kwe-Anandamide (AEA), kububulumko ukusebenzisa izongezo kumthamo omiselweyo. Ngokubanzi, iAnandamide (AEA) iyafumaneka kwioyile (70% kunye ne-90%) kunye neefom zePowder (50%). I-China iye yaba ngumlimi ophambili we Anandamide (AEA) isongezelelo.

 

Yintoni i Cannabidiol (CBD)?

I-Cannabidiol (i-CBD) yeyesibini iikhompawundi ezisebenzayo ezibizwa ngokuba zii-cannabinoids ezifumaneka kwi i-cannabis sativa (intsangu okanye i-hemp). I-Tetrahydrocannabinol (i-THC) yeyona ixhaphakileyo kwaye ikwangoyena mntu usebenze ngengqondo kwi-cannabinoid efumaneka kwisityalo se-cannabis. I-THC inxulunyaniswa nokufumana uvakalelo "oluphezulu".

Nangona kunjalo, i-CBD ayisebenzi ngokwasemphefumlweni kwaye ifunyenwe kwisityalo se-hemp esinexabiso eliphantsi le-THC. Le propati yenze ukuba i-CBD ifumane ukuthandwa kwicandelo lezempilo kunye nokuba sempilweni.

I-Cannabidiol (i-CBD) yeoyile ngakwelinye icala ivela kwisityalo se-cannabis ngokongeza i-CBD ekhutshiweyo kwioyile yenethiwekhi njengeoyile yembewu ye-hemp okanye ioyile yekhokhonathi.

 

Isebenza njani iCannabidiol (CBD)?

Imizimba yethu inenkqubo ekhethekileyo ebizwa ngokuba yinkqubo ye-endocannabinoid ejongene notshintsho lomzimba. Umzimba uvelisa ii-endocannabinoids zodwa. I-endocannabinoid zii-neurotransmitters ezibophelela kwii-cannabinoid receptors.

Zimbini ii-receptors ze-cannabinoid; CB1 kunye ne-CB2 receptors. Ii-receptors ze-CB1 zifumaneka kuwo wonke umzimba kwaye ngakumbi kwingqondo. Zilawula imeko yakho, imvakalelo, intshukumo, ukuthanda ukutya, inkumbulo kunye nokucinga.

Ii-receptors ze-CB 2 kwelinye icala ziyafumaneka kwinkqubo yomzimba yokuzikhusela kwaye zichaphazela ukudumba kunye nentlungu.

Ngelixa i-THC ibopha ngokuqinile kwii-receptors ze-CB1, i-CBD ayibopheleli ngokuqinileyo kwii-receptors kodwa endaweni yoko ivuselela umzimba ukuba uvelise ii-endocannabinoids ezingakumbi. I-CBD nangona kunjalo inokubopha okanye isebenze ezinye ii-receptors ezifana ne-serotonin receptor, vanilloid, kunye ne-PPARs [i-peroxisome proliferator-activated receptors] receptors. I-CBD ikwasebenza njengokuchasene ne-GPR55-receptors eziyinkedama.

I-CBD ibophelela kwi-receptor ye-serotonin ebandakanyekayo kuxinzelelo, ukulala, ukuqonda iintlungu, ukuthanda ukutya, isicaphucaphu kunye nokugabha.

I-CBD ikwabopha kwi-vanilloid receptor eyaziwa njengeyokulamla iintlungu, ukudumba kunye nobushushu bomzimba.

I-CBD kodwa isebenza ngokuchasene ne-GPR55 receptor edla ngokubonakaliswa kwiindidi ezahlukeneyo zomhlaza.

I-Cannabidiol ikwasebenza njenge-arhente echasayo. Iyalwa okanye inciphisa ukudumba.

I-Cannabidiol inayo iipropati ze-antioxidant ezenza ukuba kupheliswe ii-radicals zasimahla ezihlala zinxulunyaniswa nokuphazamiseka okwandayo.

 

Cannabidiol (CBD) setyenziso

Oku kulandelayo kukusetyenziswa kwe-cannabidiol;

 

Ukunyanga isifo sokuhlutha (isifo sokuwa)

I-Cannabidiol isetyenziselwa ukuphatha ukuxhuzula. I-CBD inokuchaphazela amajelo eseli yeeseli zemithambo-luvo. Into ebalaseleyo kwisifo sokuwa kukuhamba okungaqhelekanga kwesodium ngaphakathi nangaphandle kweeseli. Oku kubangela ukuba umlilo uvuthe ngokungaqhelekanga ukhokelela ekubanjweni. I-CBD ifunyenwe ukunciphisa oku kungahambi ngokungaqhelekanga kwesodium ngenxa yoko kunciphisa ukuxhuzula.

Ezinye iimveliso ze-CBD kubandakanya i-Epidiolex zivunyiwe ukunyanga ukuxhuzula okubangelwa yi-Lennox-Gastaut syndrome, Dravet syndrome, okanye tuber sclerosis complex. Eli chiza likagqirha liyasetyenziswa kunye namanye amachiza okulwa ukuxhuzula ukunyanga ukuxhuzula kubantu abanesifo seSturge-Weber, isifo esosuleleko esinxulumene nokusuleleka, kunye nokuphazamiseka kwemfuza okubangela ukunganyangeki.

Kuphononongo luka-2016 olubandakanya abantu abangama-214 abanesathuthwane, i-CBD yenziwa nge-2 ukuya kwi-5 mg yonke imihla iiveki ezili-12 ukongeza kunyango lwesifo sokuwa. Kwafunyaniswa ukuba abathathi-nxaxheba babenokubanjwa okumbalwa ngenyanga.

 

Ingasetyenziselwa ukunyanga umhlaza

Ioli yeCannabidiol ingasetyenziselwa ukunciphisa iimpawu ezinxulumene nomhlaza kunye nemiphumo emibi yonyango lomhlaza njengentlungu, isicaphucaphu kunye nokugabha.

Kuphononongo lwezigulana ezili-16 ezinomhlaza ezifumana ichemotherapy, i-CBD esetyenzisiweyo kunye ne-THC yafunyanwa ukunciphisa iziphumo ezinxulumene nekhemotherapy ezinjengokugabha nokugabha.

Olunye uphononongo lubonakalise ukuba i-CBD ikuthintele ngokufanelekileyo ukwanda komhlaza wamabele kwiimpuku.

 

Ibonisa iipropathi zokuthintela ukhuseleko

Amandla e-CBD okuphembelela inkqubo ye-endocannabinoid kunye nezinye iinkqubo zokubonisa ubuchopho zenza ukuba kube luncedo kubantu abaneengxaki zemithambo-luvo. Ioyile ye-CBD inokunciphisa ukudumba okunxulunyaniswa nokuphazamiseka kwe-neurodeergenerative.

Uninzi lwezifundo zijolise ekusetyenzisweni kwe-CBD kunyango lweengxaki zemithambo-luvo ezinje ngokuxhuzula kunye ne-multiple sclerosis. Uphando lubonisa ukusetyenziswa kwayo ekunyangeni ezinye iingxaki ezinje ngesifo se-Alzheimer kunye nesifo sika-Parkinson.

Kwisifundo sexesha elide seempuku ezichazwe kwisifo se-Alzheimer, i-CBD yafunyanwa ukuthintela ukwehla kwengqondo.

 

Ukunyanga uhlobo 1 lweswekile

Uhlobo lwe-1 yeswekile luhlobo lwesifo seswekile olwenzeka xa amajoni omzimba ehlasela iiseli zepancreas, oku kubangela ukudumba.

I-CBD ifunyenwe inika iipropathi ezichasayo, inokuthi ithomalalise ukudumba okanye ilibazise ukwenzeka kohlobo lweswekile 1.

Kuphononongo lweempuku ezinesifo seswekile, i-CBD yafunyanwa ikhusela ii-neurons ngokuthintela ukwehla kwengqondo kunye nokunciphisa ukudumba kwentliziyo.

 

Cannabidiol (CBD) iinzuzo

I-Cannabidiol inoluhlu olubanzi lwezibonelelo zonyango.

Apha ngezantsi kukho izibonelelo ze-cannabidiol;

 

Ngamana unokunciphisa uxinzelelo kunye noxinzelelo

I-Cannabidiol (i-CBD) inokunceda ukunciphisa uxinzelelo kunye nokunciphisa iindlela zokuziphatha ezinxulumene noxinzelelo ezinxulunyaniswa neemeko ezinje ngoxinzelelo ngokubanzi, ukuphazamiseka, ukonwaba ekuhlaleni, kunye noxinzelelo lwasemva koxinzelelo (PTSD).

Kuphononongo lweempuku, i-cannabidiol yafunyanwa ibonakalisa zombini uxinzelelo kunye noxinzelelo.

 

Inokudambisa iintlungu

I-CBD ibonelela ngesiqabu kwintlungu yendalo kunamayeza aqhelekileyo.

Imizimba yethu inenkqubo ekhethekileyo ye-endocannabinoid enoxanduva lokulawula ukulala, iintlungu, ukudumba kunye nokuphendula kwamajoni omzimba. Umzimba ke ngoko uvelisa i-endocannabinoids, ii-neurotransmitters ezibophelela kwii-cannabinoid receptors kwinkqubo yakho yeemvakalelo.

I-CBD ibonakalisile ukuba nefuthe kwinkqubo ye-endocannabinoid ngaloo ndlela kunciphisa iintlungu kunye nokudumba.

Ngokudibene ne-THC, ioyile ye-CBD inokusetyenziselwa ukunyanga iintlungu ezinxulumene neemeko ezahlukeneyo ezinjenge-multiple sclerosis, isifo samathambo, iintlungu zesciatic nerve kunye nokwenzakala kwethambo lomqolo.

Kuphononongo lwabantu abane-rheumatoid arthritis, i-CBD esetyenziswe kunye ne-THC yafunyaniswa ukuba iyaziphelisa iintlungu ngexesha lokuhamba kunye nokuphumla kunye nokuphucula umgangatho wokulala kwizigulana.

 

Ngamana unokunciphisa amaqhakuva

Amabala yimeko yesikhumba echaphazela abantu abaninzi. Isenokuba ngenxa yemfuza, ukudumba, kunye nokuveliswa kakhulu kwe-sebum (into enamafutha eyenziwe ngamadlala asabisayo kulusu).

Uphando lubonisa ukuba i-CBD inokunceda ukunciphisa amaqhakuva ngokwenza njenge-arhente echasayo kunye nokunciphisa imveliso ye-sebum.

Umzekelo, uphononongo lomntu lufumanise ukuba ioyile ye-CBD ikwazile ukuthintela ukuveliswa kakhulu kwe-sebum ngamadlala asebenzayo ngenxa yoko unyango olusebenzayo lwamabala.

 

Ngamana unokunceda ukuyeka ukutshaya kunye nokuyeka iziyobisi

I-CBD ngohlobo lwe-inhaler inokunceda abantu abatshayayo ukuba basebenzise iisigarethi ezimbalwa kunye nokunciphisa ukuba likhoboka le-nicotine. Oku kudlala indima ekuncedeni umntu ayeke ukutshaya.

Kwisifundo se-2018 se-CBD saqatshelwa ukunceda ukunciphisa umnqweno wecuba emva kokurhoxa. Kwafunyanwa ukunceda umntu ukuba akhululeke.

I-Cannabidiol (i-CBD) inokubonelela ngezinye izibonelelo kubandakanya;

  • Ngamana unokubanceda abantu abangenabuthongo ukuba bafumane umgangatho kunye nokulala okungaphazamiseki
  • Ngaba unokukukhulula kwintloko ebuhlungu okanye kwimigraine,
  • Ngaba kunokunceda ukunciphisa isicaphucaphu,
  • Unokunceda ekunciphiseni ukwaliwa okanye isifuba
  • Ingasetyenziselwa unyango lweemeko zemiphunga.

 

Cannabidiol (CBD) umyinge 

Umthamo weoyile ye-Cannabidiol uxhomekeke kuhlobo lolawulo, injongo ekujoliswe kuyo, ubudala, kunye nezinye iimeko ezisisiseko. Ukuba ufuna ukusebenzisa ioyile ye-cannabidiol kuya kufuneka ubonane nogqirha wakho malunga nendlela yokuthatha ioyile ye-CBD ngaphambi kokuba uyifumane ngengcebiso yeengcali malunga nokusetyenziswa ngokufanelekileyo kunye nedosi. Uyithatha njani ioyile ye-CBD iya kuxhomekeka kuhlobo lolawulo kubandakanya;

  • Iipilisi kunye neepilisi zithathwa ngomlomo okanye ngeelwimi ezincinci
  • I-oyile ye-Cbd ithathwa ngomlomo
  • Ioyile ye-Cbd yesicelo eluswini
  • Ukufafaza impumlo ngokuphefumla

Kuba i-cannabidiol intsha kakhulu akukho mgangatho usemgangathweni wokusetyenziswa ngeendlela ezahlukeneyo. Nangona kunjalo, i-FDA ivume ukusetyenziswa kwe-Epidiolex, eyenye yeemveliso ezivela kwi-cannabis. Kuvunyiwe kunyango lwesifo sokuwa kakhulu esibangelwa yi-Dravet syndrome okanye i-Lennox-Gastaut syndrome.

Umthamo ocetyiswayo we-Epidiolex ngolu hlobo lulandelayo:

  • Umthamo wokuqala ngu-2.5 mg / Kg wobunzima bomzimba obuthathwe kabini yonke imihla, usenza idosi eyi-5 mg / kg ngosuku ngalunye.
  • Emva kweveki enye, idosi inokunyuswa iye kwi-1 mg / kg kabini yonke imihla, eyi-5 mg / kg ngosuku.

Ngelixa izibonelelo zeoyile ze-CBD zichaziweyo umntu unokufumana ezinye iziphumo ebezingalindelekanga ze-cannabidiol kubandakanya isicaphucaphu, ukudinwa, urhudo, ukuphelelwa ngumdla wokutya kunye nokucaphuka.

 

Cannabidiol (CBD) Iyathengiswa (Thenga Cannabidiol (CBD) ngobuninzi)

Ioli yeCannabidiol iyathengiswa ifumaneka ngokulula kwi-Intanethi. Nangona kunjalo, xa ucinga ukuba i-cannabidiol ithenge kumthombo othembekileyo ovunyiweyo wokuthengisa ioyile ye-cannabidiol ukufumana eyona oyile ye-CBD.

Ungajonga uphononongo lwabathengi kwiiwebhusayithi ezininzi ukufumana umthengisi weemveliso ze-CBD othembekileyo onikezela ngeoyile efanelekileyo ye-CBD.

Soloko uthenga i-cannabidiol (i-CBD) ngesixa esikhulu ukonwabela amaxabiso anesaphulelo.

Landela imiyalelo yendlela yokuthatha ioyile ye-CBD ngononophelo ukuthintela ukufumana iziphumo ezinokubakho zeoyile ye-CBD.

 

 

Kuyiwaphi thenga i-Anandamide (AEA) ipowder ngobuninzi

Cofttek   imveliso

Eyasungulwa ngo-2008, iCofttek yinkampani ephezulu yokuThengisa ukutya kwiDolophu yaseLuohe, kwiPhondo laseHenan, eChina.

  • Iphakheji: 25kg / igubu

Ndiyathemba ukuba oku kuyanceda !! Ulinde ntoni emva koko? Fumana iAnandamide ekhaya kwaye wenze ubomi bube lula!

 

Ucaphulo
  1. IMallet PE, iBeninger RJ (1996). "I-endo native cannabinoid receptor agonist anandamide impairs memory in rats". Ukuziphatha kwamayeza. 7 (3): 276–284
  2. UMechoulam R, uFride E (1995). "Indlela engacwangciswanga eya kwi-endo native brain i-cannabinoid ligands, i-anandamides". KwiPertwee RG (ed.). Ii-cannabinoid receptors. IBoston: Icandelo leendaba. iphepha. 233–
  3. Rapino, C.; IBattista, N.; Bari, M.; IMaccarrone, M. (2014). "I-Endocannabinoids njengama-biomarkers okuzala komntu". Ukuhlaziywa koLuntu. 20 (4): 501-516.
  4. (2015). I-Cannabidiol (i-CBD) kunye ne-analogs yayo: uphononongo lwefuthe labo kukudumba. I-Bioorganic kunye neMedical Chemistry, 23 (7), 1377-1385. INGXELO: 10.1016 / j.bmc.2015.01.059.
  5. ICorroon, J., kunye nePhillips, JA (2018). Isifundo esinqamlezileyo saBasebenzisi beCannabidiol. I-cannabis kunye nophando lwe-cannabinoid, 3 (1), 152-161. https://doi.org/10.1089/can.2018.0006.
  6. IZiko leLizwe leNgcaciso yeBiotechnology (2020). Isishwankathelo seCompChem Compound seCID 644019, iCannabidiol. Ibuyiswe ngo-Okthobha 27, 2020, ukusuka https://pubchem.ncbi.nlm.nih.gov/compound/Cannabidiol.
  7. R de Mello Schier, A., P de Oliveira Ribeiro, N., S Coutinho, D., Machado, S., Arias-Carrión, O., A Crippa, J.,… kunye no-C Silva, A. (2014) . Iziphumo zokuthintela uxinzelelo kunye noxinzelelo lwe-cannabidiol: ikhompawundi ye-Cannabis sativa. I-CNS kunye nokuphazamiseka kwemithambo-lujoliso lweethagethi (ezazikho iithagethi zangoku ze-drug-CNS kunye ne-Neurological Disorders), 13 (6), 953-960.
  8. Intsikelelo, EM, Steenkamp, ​​MM, Manzanares, J., & Marmar, CR (2015). I-Cannabidiol njengonyango olunokubakho lokuphazamiseka koxinzelelo. Neurotherapeutics: Ijenali yoMbutho waseMelika wovavanyo lweNeuroTherapeutics12(4), 825–836. https://doi.org/10.1007/s13311-015-0387-1
  9. I-ANANDAMIDE (AEA) (94421-68-8)

 

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