Yintoni iAnandamide (AEA)

Anandamide (AEA), Ikwabizwa ngokuba yimolekyuli yolonwabo, okanye N-arachidonoylethanolamine (AEA), yi-acid fatty neurotransmitter. Igama elithi Anadamida (AEA) lithathwe kwiSanskrit Yovuyo "Ananda." URafael Mechoulam waqulunqa eli xesha. Njani, kunye nabancedisi bakhe ababini, u-WA Devane kunye noLumír Hanuš, baqala ukufumanisa i- "Anandamide" ngo-1992.

Yintoni iCannabidiol (CBD)?

I-Cannabidiol (i-CBD) yeyesibini iikhompawundi ezisebenzayo ezibizwa ngokuba zii-cannabinoids ezifumaneka kwi i-cannabis sativa (intsangu okanye i-hemp). I-Tetrahydrocannabinol (i-THC) yeyona ixhaphakileyo kwaye ikwangoyena mntu usebenze ngengqondo kwi-cannabinoid efumaneka kwisityalo se-cannabis. I-THC inxulunyaniswa nokufumana uvakalelo "oluphezulu".
Nangona kunjalo, i-CBD ayisebenzi ngokwasemphefumlweni kwaye ifunyenwe kwisityalo se-hemp esinexabiso eliphantsi le-THC. Le propati yenze ukuba i-CBD ifumane ukuthandwa kwicandelo lezempilo kunye nokuba sempilweni.
I-Cannabidiol (i-CBD) yeoyile ngakwelinye icala ivela kwisityalo se-cannabis ngokongeza i-CBD ekhutshiweyo kwioyile yenethiwekhi njengeoyile yembewu ye-hemp okanye ioyile yekhokhonathi.

I-Anandamide kunye ne-Cannabidiol FAQ

Yintoni iAnandamide?

I-Anandamide, ekwabizwa ngokuba yi-N-arachidonoylethanolamine, yi-fatty acid neurotransmitter ethathwe kwi-non-oxidative metabolism ye-eicosatetraenoic acid, omega-6 fatty acid. Igama lithathwe kwigama lesi-Sanskrit ananda, elithetha "uvuyo, ulonwabo, uyolo", kunye ne-amide.

Ngaba i-Anandamide ihomoni?

Uphando lubonelela ngekhonkco lokuqala phakathi kwe-oxytocin - ebizwa ngokuba yi "hormone yothando" - kunye ne-anandamide, ebizwa ngokuba yi "molekyuli yolonwabo" ngendima yayo ekusebenziseni ii-cannabinoid receptors kwiiseli zengqondo ukuphakamisa ukhuthazo kunye nolonwabo.

Ngaba i-anandamide inomdla okanye iyathintela?

Ukuqukumbela, ii-receptors ze-cannabinoid zohlobo lwe-CB1 kunye ne-endo native ligand, i-anandamide, ziyabandakanyeka kulawulo lwe-neuronal excitability, ngaloo ndlela kuncitshiswa i-neurotransmission ethandabuzekayo kwindawo ye-presynaptic, indlela enokuthi ibandakanyeke kuthintelo lokonwaba okugqithisileyo okukhokelela .

Zeziphi ezi zimbini ze-endocannabinoids eziphandwe kakhulu eziveliswa ngumzimba ngokwemvelo?

Abaphandi bacinga ukuba kunokubakho i-receptor yesithathu ye-cannabinoid elinde ukufunyanwa. I-Endocannabinoids zizinto ezenziwe yimizimba yethu ngokwendalo ukukhuthaza ezi receptors. Ezi zimbini ziqondwa kakuhle kwezi molekyuli zibizwa ngokuba yi-anandamide kunye ne-2-arachidonoylglycerol (2-AG).

Ngaba umzimba womntu unayo inkqubo ye-cannabinoid?

Inkqubo ye-cannabinoid engapheliyo-ebizwa ngokuba sisityalo esikhokelele ekufumaneni kwayo-yenye yezona nkqubo zibaluleke kakhulu zomzimba ezibandakanyeka ekumiseni nasekugcineni impilo yabantu. I-Endocannabinoids kunye nee-receptors zazo zifumaneka kuwo wonke umzimba: kwingqondo, kwizitho zomzimba, kwizicubu ezinxibelelanayo, kwiidlala, nakwiiseli zomzimba.

Yayiyintoni i-cannabinoid yokuqala eyafunyanwa?

Ngo-1992, ilebhu kaMechoulam yabekela bucala i-endocannabinoid yokuqala: imolekyuli eyathi ekugqibeleni yahlelwa njenge-CB1 receptor egonist. Yachongwa njenge-arachidonoyl ethanolamide kwaye ibizwa ngokuba yi-anandamide.

Ngaba i-anandamide itshokolethi?

I-THC, nangona kunjalo, ayifumaneki kwitshokholethi. Endaweni yoko, enye ikhemikhali, i-neurotransmitter ebizwa ngokuba yi-anandamide, ibekwe yodwa kwitshokholethi. Into enomdla kukuba, i-anandamide nayo iveliswa ngokwendalo kwingqondo.

Ngaba itshokholethi i-cannabinoid?

I-Anandamide ibizwa ngokuba yi-endocannabinoid kuba yenziwe ngumzimba wethu kwaye ilingisa ii-cannabinoids ezifumaneka kwisityalo se-marijuana. Ke, isithako kwitshokholethi kunye nesithako kwisityalo sentsangu zombini ziyakwazi ukukhuthaza inkqubo yengqondo yethu yentsangu ye-neurotransmitter.

Ngaba itshokholethi inayo i-theobromine?

I-Theobromine yeyona alkaloid iphambili efumaneka kwicocoa kunye netshokholethi. Icocoa powder inokwahluka ngokwenani le-theobromine, ukusuka kwi-2% theobromine, ukuya kuthi ga kumanqanaba aphezulu ajikeleze i-10%. … Kuhlala kukho iindawo ezixineneyo eziphezulu ebumnyameni kune chocolate yetshisi.

Zeziphi ii-cannabinoids eziqhelekileyo?

Ezi zimbini eziphambili ze-cannabinoids yi-delta-9-tetrahydrocannabinol (THC) kunye ne-cannabidiol (CBD). Eyona nto idume kakhulu kwezi zimbini yi-delta-9-tetrahydrocannabinol (THC), eyikhemikhali ejongene neziphumo zengqondo ye-cannabis.

Yintoni imolekyuli yolonwabo?

I-Anandamide yikhemikhali yobuchopho eyaziwa kancinci ebizwa ngokuba yi "molekyuli yolonwabo" ngendima eyidlalayo ekuveliseni iimvakalelo zolonwabo. … Isebenza ngokubophelela kwizamkeli ezifanayo kwingqondo njengeyona nto iphambili ekuthinteleni ukusebenza kwentsangu.

Ngaba i-anandamide sisiyobisi?

I-Anandamide, i-ligand engapheliyo ye-cannabinoid ye-CB1 receptors, ivelisa iziphumo zokuziphatha ezifanayo nezo ze-Δ9-tetrahydrocannabinol (THC), esona sithako siphambili sentsangu.

Ngaba umzimba womntu uvelisa ii-cannabinoids?

I-Endocannabinoids. I-Endocannabinoids, ekwabizwa ngokuba zii-cannabinoids ezingapheliyo, ziimolekyuli ezenziwe ngumzimba wakho. Ziyafana ne-cannabinoids, kodwa ziveliswa ngumzimba wakho.

Ngaba i-CBD iyonyusa i-dopamine?

I-CBD ikwakhuthaza i-adenosine receptor ukukhuthaza ukukhutshwa kwe-glutamate kunye ne-dopamine neurotransmitters. Ngokunxibelelana kwayo ne-dopamine receptors, kuyanceda ukuphakamisa amanqanaba e-dopamine kunye nokulawula ukuqonda, inkuthazo kunye nokuziphatha okufuna umvuzo.

Ngaba i-Indica yonyusa i-dopamine?

kunciphisa iintlungu ezibuhlungu. kwandisa ukutya. yonyusa i-dopamine (i-neurotransmitter enceda ukulawula umvuzo wengqondo kunye namaziko olonwabo) ekusebenziseni ixesha lasebusuku.

Loluphi uhlobo lweziyobisi itshokholethi?

Ukongeza kwiswekile, itshokholethi inezinye iziyobisi ezibini, i-caffeine kunye ne-theobromine. Itshokholethi ayivuseleli kuphela ii-opiate receptors kwingqondo yethu, ikwabangela ukukhutshwa kwee-neurochemicals kumaziko olonwabo engqondo.

Yintoni i-anandamide eyenzayo emzimbeni?

Imizimba yethu yenza i-anandamide kwimfuno, ukuze isetyenziswe xa ifuneka ekugcineni i-homeostasis. I-Anandamide ikwenza oku ngokunceda ukulawula ukudumba kunye nokusayina kwe-neuron. Njengoko idaliwe, ibopha ikakhulu ii-cannabinoid receptors CB1 kunye ne-CB2 kanye njengee-cannabinoids ezinje nge-THC xa zingena.

Yintoni inkqubo ye-cannabinoid receptor?

Ii-Cannabinoid receptors, ezibekwe emzimbeni wonke, ziyinxalenye yenkqubo ye-endocannabinoid, ebandakanyeka kwiinkqubo ezahlukeneyo zomzimba kubandakanya ukutya, iintlungu, imvakalelo, kunye nenkumbulo. Ii-Cannabinoid receptors zodidi lwee-receptors zeeseli ezikwiseli ye-protein ye-G edityanisiweyo.

Ngawaphi amaqela ahlukeneyo asebenzayo akhoyo kwi-anandamide?

Amaqela e-Anandamide asebenzayo abandakanya ii-amide, ii-esters, kunye nee-ether ze-polyunsaturated fatty acids, kunye nokwabelana ngokwakha ngokubalulekileyo ii-pharmacophores kunye ne-D-9-tetrahydrocannabinol (THC).

Wanyusa njani amanqanaba e-anandamide ngokwendalo?

Yitya ukutya okunotyebileyo kwezi ziqhamo kwaye uthintele imveliso yakho ye-FAAH eyonyusa amanqanaba akho e-anandamide! Itshokholethi kukunye ukutya okunokunceda ukukhulisa i-anandamide. Inesakhi esaziwa ngokuba yi-ethylenediamine ethintela imveliso ye-FAAH. Gcina oku kutya kuthathu engqondweni ngexesha elizayo xa usiya kwivenkile.

Ngaba itshokholethi ine-anandamide?

I-THC, nangona kunjalo, ayifumaneki kwitshokholethi. Endaweni yoko, enye ikhemikhali, i-neurotransmitter ebizwa ngokuba yi-anandamide, ibekwe yodwa kwitshokholethi. Into enomdla kukuba, i-anandamide nayo iveliswa ngokwendalo kwingqondo.

Ngaba itshokholethi sisiyobisi?

Itshokholethi inexabiso elikhulu leswekile. Ukongeza kwiswekile, itshokholethi inezinye iziyobisi ezibini, i-caffeine kunye ne-theobromine. Itshokholethi ayivuseleli kuphela ii-opiate receptors kwingqondo yethu, ikwabangela ukukhutshwa kwee-neurochemicals kumaziko olonwabo engqondo.

Yintoni iziyobisi kwitshokholethi?

I-Theobromine yeyona alkaloid iphambili efumaneka kwicocoa kunye netshokholethi.

Yeyiphi imichiza ekhoyo kwitshokholethi?

I-Theobromine, eyayisaziwa njenge-xantheose, yi-alkaloid ekrakra yesityalo sekhokho, kunye nefomula yeekhemikhali C7H8N4O2. Ifumaneka kwitshokholethi, kunye nokunye ukutya okuninzi, kubandakanya amagqabi esityalo seti, kunye nekola nut.

Ngaba itshokholethi iyayinyusa i-serotonin?

Nangona kunjalo, kuba itshokholethi iqulethe i-tryptophan, ukonyuka kweserotonin kunokunceda uchaze ukuba kutheni umntu enokuziva onwabile, ezolile, okanye exhalabile emva kokutya iqhekeza lekhekhe yakhe yetyhokolethi (iSerotonin).

Yintoni i-anandamide ejongene nayo?

I-Anandamide idlala indima kummiselo wokuziphatha kokondla, kunye nokuveliswa kwe-neural yenkuthazo kunye nolonwabo. I-Anandamide itofelwe ngqo kulwakhiwo lobuchopho obunxulumene nomvuzo we-forebrain yonyusa iimpendulo ezithandekayo zeempuku kwincasa ye-sucrose enomvuzo, kunye nokwandisa ukutya.

Ngaba i-CBD yintsholongwane?

I-THC kunye ne-CBD zinamandla okulwa ne-antioxidants-enamandla kune-vitamin C kunye no-E. Ngapha koko, i-US Government Patent 1999/008769 ilungiselelwe ngokukodwa iipropathi ze-neuroprotectant kunye ne-antioxidant ye-cannabinoids.

Yenza ntoni i-enzyme ye-FAAH?

I-fatty acid i-amide hydrolase (i-FAAH) yi-enzyme ye-mammalian ehambelana ne-membrane enzyme ethoba usapho olunamanqatha e-amide yosasazo lwee-lipids, ezibandakanya i-endo native cannabinoid anandamide kunye ne-oleamide.

I-CBD iyichaphazela njani i-anandamide?

Izifundo zebhayoloji zibonisa ukuba i-cannabidiol inokunyusa ukubonakaliswa kwe-anandamide engagungqiyo ngokungathanga ngqo, ngokuthintela ukonakaliswa kwe-intracellular ye-anandamide ebanjiswe yi-enzyme fatty acid amide hydrolase (FAAH).

Ithetha ntoni i-cannabinoid?

Igama le-cannabinoid libhekisa kuyo yonke into yemichiza, nokuba yeyiphi na imvelaphi okanye imvelaphi, ejoyina ii-receptors ze-cannabinoid zomzimba kunye nengqondo kwaye ezineziphumo ezifanayo kwezo ziveliswa sisityalo seCannabis Sativa. … Ezi zinto zimbini ziphambili zi-delta-9-tetrahydrocannabinol (THC) kunye ne-cannabidiol (CBD).

Yintoni inkqubo ye-endocannabinoid kwaye yenza ntoni?

Umzimba womntu uqulethe inkqubo ekhethekileyo ebizwa ngokuba yi-endocannabinoid system (ECS), ebandakanyekayo kulawulo lwemisebenzi eyahlukeneyo kubandakanya ukulala, ukutya, iintlungu kunye nokuphendula kwenkqubo yomzimba yokuzikhusela.

Ngaba umzimba unee-cannabinoid receptors?

Ii-Cannabinoid receptors, ezibekwe emzimbeni wonke, ziyinxalenye yenkqubo ye-endocannabinoid, ebandakanyeka kwiinkqubo ezahlukeneyo zomzimba kubandakanya ukutya, iintlungu, imvakalelo, kunye nenkumbulo. … Ngo-2007, kwabanjwa ii-cannabinoids ezininzi kwi-G protein-coupled receptor GPR55 kwingqondo.

Ngaba i-CBD inyusa i-anandamide?

Ngokwe-cannabinoid i-receptor-exhomekeke kwiziphumo ze-CBD kummiselo woloyiko olufundileyo oluchazwe apha ngasentla, i-CBD inyusa amanqanaba e-anandamide ngokuthintela ukuphinda kuthathe kwakhona ukuhambisa kunye nokuthotywa yi-FAAH.

Yeyiphi i-cannabinoid esetyenziselwa uxinzelelo?

Ngethamo elisezantsi le-THC kunye nedosi emodareyithayo ye-CBD, iprofayili ye-cannabinoid ye-Harlequin ilungelelene nabalwi bexhala abangayikhathalelanga imincili. Eyona terpene yayo ininzi yi-myrcene, ekukholelwa ukuba inefuthe lokuphumla kwaye isetyenzisiwe kwimbali njengesixhobo sokulala.

Ngaba i-CBD iyalunceda uxinzelelo?

I-CBD ihlala isetyenziselwa ukujongana nexhala, kunye nezigulana ezifumana ubunzima bokungalali, uphononongo lucebisa ukuba i-CBD inokunceda ekulaleni nasekulaleni. I-CBD inokubonelela ngenketho yokunyanga iintlobo ezahlukeneyo zentlungu engapheliyo.

Ngaba utywala bulunceda ixhala?

Utywala buyadambisa kwaye buyadandathekisa obuchaphazela inkqubo ye-nervous system. Ekuqaleni, ukusela kunokunciphisa uloyiko kwaye kususe ingqondo yakho kwiingxaki zakho. Inokukunceda uzive uneentloni, ikunike amandla, kwaye ikwenze uzive ukhululeke ngokubanzi.

Ndifumana njani ukuba ndinexhala?

Ukufumanisa ingxaki yokuxhalaba, ugqirha wenza uvavanyo lomzimba, abuze malunga neempawu zakho, kwaye acebise uvavanyo lwegazi, olunceda ugqirha ukuba abone ukuba ngaba enye imeko, enje ngehypothyroidism, inokubangela iimpawu zakho. Ugqirha usenokubuza nangawo nawaphi na amayeza owasebenzisayo.

Zeziphi iziyobisi akufuneki zithathwe kunye ne-CBD?

  • Izidambisi-zintsholongwane (ezifana ne-fluoxetine, okanye i-Prozac)
  • Amayeza anokubangela ukozela (i-antipsychotic, benzodiazepines)
  • I-Macrolide antibiotics (erythromycin, clarithromycin)
  • Amayeza entliziyo (ezinye iicalcium block blockers)

Ngaba i-CBD iyayikhupha i-dopamine?

I-CBD ikwakhuthaza i-adenosine receptor ukukhuthaza ukukhutshwa kwe-glutamate kunye ne-dopamine neurotransmitters. Ngokunxibelelana kwayo ne-dopamine receptors, kuyanceda ukuphakamisa amanqanaba e-dopamine kunye nokulawula ukuqonda, inkuthazo kunye nokuziphatha okufuna umvuzo.

Yeyiphi i-dopamine ephantsi evakalelwa ngathi?

Ezinye zeempawu kunye neempawu zeemeko ezinxulumene nokusilela kwe-dopamine zibandakanya: iincampu zemisipha, i-spasms, okanye ukungcangcazela. iintlungu neentlungu. ukuqina kwezihlunu.

Ngaba icaffeine inyusa amanqanaba edopamine?

I-caffeine, eyona nto isetyenziswa kakhulu ehlabathini, isetyenziselwa ukukhuthaza ukuphaphama kunye nokwenza ukuba siphaphile. Njengezinye iziyobisi ezikhuthaza ukuvusa (izikhuthazi kunye ne-modafinil), icaffeine yonyusa uphawu lwe-dopamine (DA) kwingqondo, eyenza ikakhulu ngokuchasene ne-adenosine A2A receptors (A2AR).

Yeyiphi indlela ekhawulezayo yokwandisa i-dopamine?

  • Yitya iiprotheyini ezininzi
  • Yitya amanqatha amancinci
  • Sebenzisa iiProbiotic
  • Yitya iimbotyi zeVelvet
  • Zilolonge rhoqo
  • Fumana Ubuthongo obuhle
  • Mamela umculo
  • Cinga
  • Fumana ukukhanya okwaneleyo kwelanga
  • Cinga ngeziNcedisi

Ngaba i-CBD iyalunceda uxinzelelo?

I-CBD ihlala isetyenziselwa ukujongana nexhala, kunye nezigulana ezifumana ubunzima bokungalali, uphononongo lucebisa ukuba i-CBD inokunceda ekulaleni nasekulaleni. I-CBD inokubonelela ngenketho yokunyanga iintlobo ezahlukeneyo zentlungu engapheliyo.

Ngaba i-CBD inyusa i-serotonin?

I-CBD ayinyusi amanqanaba e-serotonin, kodwa inokuchaphazela indlela i-receptors yeekhemikhali zobuchopho eziphendula ngayo kwi-serotonin esele ikhoyo kwinkqubo yakho. Uphononongo lwezilwanyana lwango-2014 lwafumanisa ukuba ifuthe le-CBD kwezi receptors kwingqondo zivelise zombini i-antidepressant kunye ne-anti-ixhala.

Ngaba i-CBD inokunceda kwingqondo yakho?

Abaphandi bakholelwa ukuba amandla e-CBD okusebenza kwinkqubo ye-endocannabinoid kunye nezinye iinkqubo zokubonisa ubuchopho zinokubonelela ngezibonelelo kwabo baneengxaki zemithambo-luvo. Ngapha koko, enye yezona zinto zisetyenziswayo kufundiswa i-CBD kukunyanga ukuphazamiseka kwemithambo-luvo njengokuxhuzula kunye nokuqina kwemithambo.

Ndingawanyusa njani amanqanaba e-serotonin?

  • ukutya
  • Lolonga
  • Isibane esikhanyayo
  • nezongezo
  • ukuphulula umzimba womntu ngobunono
  • Uqheliso lwemood

Yeyiphi eyona oyile ye-CBD ilungileyo yokuthenga ukunciphisa umzimba

I-Anandamide ngumlamli we-lipid osebenza njenge-endo native ligand of CB1 receptors. Ezi receptors nazo zijolise ikakhulu ekujoliseni iimolekyuli ezinoxanduva lweziphumo ze-Δ9-tetrahydrocannabinol, isithako se-psychoactive kwiCannabis sativa.

Uyenza njani i-anandamide?

Yenziwe ngokudibeneyo ukusuka kwi-N-arachidonoyl phosphatidylethanolamine ngeendlela ezininzi. Iyathotywa ikakhulu yi-fatty acid amide hydrolase (FAAH) enzyme, eguqula i-anandamide ibe yi-ethanolamine kunye ne-arachidonic acid.

Ngaba umzimba womntu uyivelisa i-CBD?

Into ongayiqondiyo, nangona kunjalo, kukuba oku kulandela kwinto yokuba umzimba womntu uvelisa i-cannabinoids yayo engapheliyo: izinto ezilinganayo zendalo ezifumaneka kwisityalo se-cannabis, njenge-THC (tetrahydrocannabinol) kunye ne-CBD (cannabidiol).

Ngaba i-CBD ilungile ngenene?

Akukho bungqina, umzekelo, bokuthi i-CBD inyanga umhlaza. Kukho ubungqina obulinganiselweyo bokuthi i-CBD inokuphucula iingxaki zokulala, iintlungu ze-fibromyalgia, ukungxama kwemisipha okunxulumene ne-multiple sclerosis, kunye noxinzelelo. UGqirha Levy uthi: “Olona ngenelo ndilubonileyo njengogqirha kukunyanga iingxaki zokulala, unxunguphalo kunye neentlungu.

Ngaba iimveliso ze-CBD zikhuselekile?

Ukusetyenziswa kwe-CBD kukwanobungozi. Nangona ihlala inyamezeleka kakuhle, i-CBD inokubangela iziphumo ebezingalindelekanga, ezinjengomlomo owomileyo, urhudo, ukunciphisa ukutya, ukozela nokudinwa. I-CBD ikwanokunxibelelana namanye amayeza owathathayo, afana nezicoci gazi.

Yenza ntoni i-CBD kwingqondo?

Ezi mpawu zinxulunyaniswe nokukwazi kwe-CBD ukusebenza kwii-receptors zengqondo ze-serotonin, i-neurotransmitter elawula imeko-bume kunye nokuziphatha ekuhlaleni. Isishwankathelo Sebenzisa i-CBD kubonisiwe ukunciphisa uxinzelelo kunye noxinzelelo kwizifundo zabantu nezilwanyana.

Ngaba i-CBD iyishiya ngokukhawuleza kangakanani le nkqubo?

I-CBD ihlala kwinkqubo yakho kangangeentsuku ezi-2 ukuya kwezi-5, kodwa olo luhlu alusebenzi kuye wonke umntu. Abanye, i-CBD inokuhlala kwinkqubo yabo iiveki.

Ifumaneka phi ianandamide?

I-Anandamide yenziwe ngokudibeneyo kwimimandla yengqondo ebalulekileyo kwimemori, iinkqubo zokucinga kunye nolawulo lokuhamba. Uphando lubonisa ukuba i-anandamide idlala indima ekwenziweni nasekuphuleni unxibelelwano lwexesha elifutshane phakathi kweeseli zemithambo-luvo, kwaye oku kunxulumene nokufunda kunye nememori.

Ngaba i-anandamide yi-cannabinoid?

Ikwabizwa ngokuba yi-N-arachidonoylethanolamine (AEA), i-anandamide inxibelelana nezamkeli zomzimba ze-CB ngokufanayo kwii-cannabinoids ezinjenge-THC. I-arhente yokubopha ye-neurotransmitter kunye ne-cannabinoid-receptor esebenza njengomthunywa wesiginali kwii-CBXNUMX receptors ezikulo mzimba.

Isebenza njani iAnandamide (AEA)

I-Anandamide (AEA) ithathwe kwimetabolism engeyiyo-oxidative ye-eicosatetraenoic acid. I-Anandamide (AEA) ngumlamli we-lipid kunye nemisebenzi njenge-endo native ligand ye-CB1 receptors kwaye imodareyitha umvuzo wayo wesekethe. I-neurotransmitter ebalulekileyo kwinkqubo ye-endocannabinoid, ethiywe ngegama le-Cannabis. Inceda ukulawula ukuhamba kweenkqubo ze-neurochemical ukugcina umzimba kunye nengqondo yakho isebenza kakuhle. Kufunyenwe ukuba ubume be-Anandamide bufana ne-tetrahydrocannabinol (THC), eyona nto iphambili kwi-Cannabis. Yiyo loo nto iAnandamide itshintsha imo ifanisa into eyaziwa ngokuba yi-Cannabis ephezulu.

Imvelo iveliswa emzimbeni wethu ngokomyalelo wobuchopho ngokuphendula kwe-condensation kwii-neurons. Impendulo ye-condensation elawulwa yi-calcium ion kunye ne-cyclic monophosphate adenosine yenzeka phakathi kwe-arachidonic acid kunye ne-ethanolamine.

I-Anandamide yonyusa ulonwabo ngokudibana ne-cannabinoid receptors kwinkqubo ye-nervous and peripheral system, CB1 kunye ne-CB2. Ii-receptors ze-CB1 zijolise ekuqhubeni iimoto (ukuhamba) kunye nokulungelelanisa, ukucinga, ukutya, imemori yamagama amafutshane, ukuqonda iintlungu kunye nokungakhuseleki. Kwangelo xesha, ii-receptors ze-CB2 zijolise kumalungu aphambili afana neLiver, Gut, kidney, Pancreas, izicubu zeAdipose, umsipha wamathambo, ithambo, iliso, amathumba, inkqubo yokuzala, inkqubo yokuzikhusela komzimba, indlela yokuphefumla, ulusu, inkqubo yovalo oluPhakathi, kunye nenkqubo yentliziyo. .

Emizimbeni yethu, i-N-arachidonoylethanolamine yehla ibe yi-fatty acid amide hydrolase (FAAH) enzyme kwaye ivelise i-arachidonic acid kunye ne-ethanolamine. Ukuba isenzo se-FAAH sika-FAAH sinokucothiswa, sinokuvuna izibonelelo zika-Anandamide's Anandamide ixesha elide.

Anandamide (AEA)
Anandamide (AEA)

Isebenza njani iCannabidiol (CBD)?

Imizimba yethu inenkqubo ekhethekileyo ebizwa ngokuba yinkqubo ye-endocannabinoid ejongene notshintsho lomzimba. Umzimba uvelisa ii-endocannabinoids zodwa. I-endocannabinoid zii-neurotransmitters ezibophelela kwii-cannabinoid receptors.

Zimbini ii-receptors ze-cannabinoid; CB1 kunye ne-CB2 receptors. Ii-receptors ze-CB1 zifumaneka kuwo wonke umzimba kwaye ngakumbi kwingqondo. Zilawula imeko yakho, imvakalelo, intshukumo, ukuthanda ukutya, inkumbulo kunye nokucinga.

Ii-receptors ze-CB 2 kwelinye icala ziyafumaneka kwinkqubo yomzimba yokuzikhusela kwaye zichaphazela ukudumba kunye nentlungu.

Ngelixa i-THC ibopha ngokuqinile kwii-receptors ze-CB1, i-CBD ayibopheleli ngokuqinileyo kwii-receptors kodwa endaweni yoko ivuselela umzimba ukuba uvelise ii-endocannabinoids ezingakumbi. I-CBD nangona kunjalo inokubopha okanye isebenze ezinye ii-receptors ezifana ne-serotonin receptor, vanilloid, kunye ne-PPARs [i-peroxisome proliferator-activated receptors] receptors. I-CBD ikwasebenza njengokuchasene ne-GPR55-receptors eziyinkedama.

I-CBD ibophelela kwi-receptor ye-serotonin ebandakanyekayo kuxinzelelo, ukulala, ukuqonda iintlungu, ukuthanda ukutya, isicaphucaphu kunye nokugabha.

I-CBD ikwabopha kwi-vanilloid receptor eyaziwa njengeyokulamla iintlungu, ukudumba kunye nobushushu bomzimba.

I-CBD kodwa isebenza ngokuchasene ne-GPR55 receptor edla ngokubonakaliswa kwiindidi ezahlukeneyo zomhlaza.

I-Cannabidiol ikwasebenza njenge-arhente echasayo. Iyalwa okanye inciphisa ukudumba.

I-Cannabidiol inayo iipropati ze-antioxidant ezenza ukuba kupheliswe ii-radicals zasimahla ezihlala zinxulunyaniswa nokuphazamiseka okwandayo.

Izibonelelo ze-Anandamide (AEA)

I-Anandamide (AEA) ilinganisa iziphumo ze-Cannabis kwinkqubo yethu, ngaphandle kwemiphumo emibi. I-Anandamide isinceda ngokukhuthaza ukusebenza kwengqondo yethu kwezi ndlela zilandelayo:

Anandamide (AEA)

Ukuphucula amandla engqondo kunye nenkumbulo

Ukuphucula amandla akho ememori yokusebenza yeyona nto iphambili Izibonelelo ze-Anandamide (AEA). Inokukunceda ukuba ube nobuchule ngakumbi ngokuqhubekeka ngolwazi kwiimbono ezintsha. Isifundo kwiimpuku sibonakalise ukuphucuka okubonakalayo ekusebenzeni kwengqondo. Ke ukuba ufuna ukuphucula izakhono zakho zohlalutyo, izakhono zokuyila, okanye wenze kakuhle kwizifundo zakho, iAnandamide sisisombululo esifanelekileyo.

② Isebenza njengomlawuli wokutya

Ukuba ufuna ukulandela ukutya okungqongqo, ulawulo lokutya kufuneka. Enye yeenzuzo zeAnandamide ngaba kunokukunceda ulawule ukutya kunye nokujikeleza kwesatiety. Unokulawula ngokulula inimba yendlala okanye iminqweno ye-junk ngoncedo lwe-Anandamide. Ngale ndlela, unokufezekisa iithagethi zakho zokulahleka kobunzima okanye iithagethi zokufumana kwakhona imilo. Kwiintsuku zanamhlanje ukuhlala usempilweni kwaye ulungile ubukhulu becala kuxhomekeke kwindlela yethu yokutya, kwaye izongezo zeAnandamide zinokusinceda. Kodwa izicwangciso zokulahleka kwesisindo kunye neAnandamide kufuneka zincedisane nezicwangciso ezifanelekileyo zokutya. Ukuyekisa okungaphantsi kunokukhokelela ekulahlekelweni ngesiquphe kobunzima bomzimba kwaye, ngenxa yoko, iingxaki zemetabolic. Kwimeko yoomama abancancisayo, ukusetyenziswa kwe-Anandamide kufuneka kuthintelwe. (5)(2015). I-Cannabidiol (i-CBD) kunye ne-analogs yayo: uphononongo lwefuthe labo kukudumba.

③ Neurogeneis

Enye indlela yokwandisa amandla akho okusebenza kwengqondo kukuba uneeseli ezintsha okanye iiseli zengqondo ngeNeurogenesis. Oku kuyinyani, ngakumbi usondele kwi-40 okanye uhambe ngaphaya kweminyaka. I-Anandamide (AEA) iyanceda kwi-Neurogenesis.

Ngapha koko, amanqanaba aphezulu amanqanaba e-Anandamide emzimbeni womntu aphelisa umngcipheko wezifo ze-neurodeergenerative ezinje ngesifo sikaPerkinson'sPerkinson, njl. Umzimba, njl. I-Anandamide (AEA) inceda abantu abadala ukuba babonwabele ubomi babo bokuthatha umhlala-phantsi ngaphandle kokukhathazeka ngemicimbi yabo yezempilo.

Anandamide (AEA)

④ Ukulawula iminqweno yesini

I-Anandamide (AEA) izibonelelo zokulawula umnqweno wakho wesondo ngeendlela ezimbini. Kwidosi encinci, inyusa iminqweno yesini. Kodwa ngethamo elinzima le-Anandamide (AEA) kunciphisa umnqweno wesini. I-Anandamide (AEA) iphucula imeko yakho yeemvakalelo kwaye inciphise uxinzelelo olunikezela isini. Kodwa idosi ephezulu ikwenza wanelise ngokwesondo, kwaye awufumani sidingo sokwabelana ngesondo.

Anandamide (AEA)

Properties Iipropati ezichasene noMhlaza

I-Anandamide (AEA) ineepropathi ze-carcinogenic ye-carcinogenic ngenxa yeempembelelo zengqondo. I-Anandamide (AEA) ilwa nokukhula kwezicubu zomhlaza. Iluncedo ngakumbi kumhlaza wamabele. Amalinge abonisa ukuba inokuba yindawo efanelekileyo yokubuyisela iziyobisi eziqhelekileyo kumhlaza. Ngapha koko, isimahla nakweyiphi na imiphumela esecaleni xa kuthelekiswa neziphumo zokutshintsha kobomi zeziyobisi zomhlaza oqhelekileyo. Kungekudala, ukwamkelwa okukhulu kwe-Anandamide (AEA) kunokunciphisa iintlungu abaguli abanomhlaza abadlula kuzo ngexesha lonyango.

Iipropati ze-antiemetic

Isihlunu kunye nokuhlanza kunokulawulwa kunye ne-Anandamide (AEA). Isebenza nge-serotonin ukulawula isicaphucaphu. Oku kwenza i-Anandamide (AEA) isisombululo se-antiemetic ngexesha le-chemotherapy kwizigulana ezinomhlaza. Oku kunokuba kuhle koomama abakhulelweyo. Kodwa kwimeko yoomama abakhulelweyo, iAnandamide (AEA) kufuneka yenziwe kuphela xa icetyiswa ngugqirha wakhe.

Iipropathi zoNcedo lweNtlungu

Ngokudibana ne-CB1, i-Anandamide (AEA) ibhloka ukuhanjiswa kweempawu zentlungu. Ngale ndlela, iAnandamide (AEA) inokusetyenziselwa ukuphelisa iintlungu ezingapheliyo kwizigulana ezinengxaki yezonyango ezifana ne-gout, i-arthritis, okanye i-sciatica. Kudala, iintlungu zihlala zihleli. I-Anandamide (AEA) sisixhobo esingqiniweyo se-migraines kunye nezinye iintloko ezibi kakhulu. Ukusetyenziswa kwe-Anandamide (AEA) izongezo ekwaluphaleni kunokubanceda boyise iintlungu kwaye kuya kuphucula nobomi babo.

Anandamide (AEA)

Umlawuli weMood

Inkqubo ye-endocannabinoid ilawula imood yethu. I-Anandamide (AEA) ilawula iingqondo zethu ezingalunganga njengoloyiko, unxunguphalo, kunye nokonyusa ulonwabo. Ngale ndlela, iAnandamide (AEA) inokusebenza njengesixhobo sokuphakamisa imo, ukuphucula impilo yengqondo, kunye nokuphucula imeko yakho yangaphakathi. Njengoko i-Anandamide (AEA) izongezo zingalunganga, kuyacetyiswa kakhulu, ngakumbi kubemi abaneminyaka yokusebenza, ekufuneka baqhubeke nokusebenza ngemveliso ephezulu kwindawo enzima kakhulu kunye noxinzelelo.

Anandamide (AEA)

Ukulwa nokudakumba

I-Anandamide (AEA) nayo inokulwa ukudangala. Uphononongo lweempuku kutshanje lubonakalise iipropathi zoxinzelelo. Uxinzelelo kunye neengxaki ezinxulumene nazo zithatha impilo yethu yengqondo neyomzimba… nakwindawo esihlala kuyo. Ukuba likhoboka le-nicotine, utywala, ukusetyenziswa gwenxa kweziyobisi kuhlala kunxulunyaniswa nokudakumba. Iimeko ezibi nangakumbi zinokukhokelela ekubeni abantu bathathe ubomi babo. Ukudakumba kunokuba yinto ebuthathaka engakhokelela nasekufeni kwabantu. I-Anandamide (AEA) inokuba sisisombululo esikhulu kule ngxaki.

⑩ Ukulwa nokudumba kunye ne-Edema

I-Anandamide (AEA) inciphisa ukudumba kweseli kunye nokudumba. Ngale ndlela, ikwaluncedo njengesisombululo esichasayo.

Ezinye iiNzuzo

I-Anandamide (AEA) inokudlala indima eluncedo ekuvuseleleni nasekumiliseleni. Izifundo zibonisa ukuba amanqanaba aphezulu e-Anandamide (AEA) aqinisekisa ukuphumelela kwe-ovulation.

Ngaphezulu kwe-60% yabantu baya kuphuhlisa uxinzelelo lwegazi okanye izifo ezinganyangekiyo zezintso. I-Anandamide (AEA) inokuguqula imisebenzi yezintso ebangela isifo. I-Anandamide (AEA) ibonise iziphumo ezilungileyo ekusombululeni iingxaki ezibangelwa luxinzelelo lwegazi oluphakamileyo.

Imithombo yendalo iAnandamide (AEA)

IiBlack Truffles (ifungi emnyama)

I-Truffles emnyama iqulethe i-Anandamide yendalo.

ii. Ulwandle kunye neeHerbs

I-Cannabis, i-clove, i-sinamoni, i-pepper emnyama, i-oregano, njl. Ukuphucula amanqanaba e-Anandamide kwimizimba yethu. Iti ngumthombo olunge kakhulu weAnandamide (AEA).

Iitshokholethi

Itshokholethi emnyama yenye yezona mithombo zibalaseleyo zeAnandamide. I-cocoa powder yenziwe nge-oleolethanolamine kunye ne-linoleoylethanolamine. Ukunciphisa ukuhla kwe-endocannabinoids kwaye ngoko kugcina amanqanaba e-Anandamide emzimbeni wethu. Kwakhona, itshokholethi ine-theobromine, enceda imveliso yeAnandamide.

iv. Izinto ezinamafutha ezibalulekileyo

Amaqanda, imbewu yeChia, imbewu yeflakisi, isardadi, imbewu ye-hemp yimithombo emihle ye-endocannabinoid eyonyusa amanqatha e-asidi. Kananjalo, oku kuphucula inqanaba le-Omega 3 kunye ne-Omega 6 emzimbeni wethu ukuphucula umsebenzi we-endocannabinoid.

Anandamide (AEA) izongezo kunye nezinye iindlela zokuphucula amanqanaba eAnandamide

CBD (Cannabidiol)

Enye yeendlela ezilungileyo zokukhuthaza inkqubo ye-endocannabinoid kukusetyenziswa kwe-CBD. I-CBD ngowona mthombo uphambili wentsangu yezonyango. I-CBD inqanda i-FAAH kwaye ke iphucula amanqanaba e-Anandamide emzimbeni wethu.

Lolonga

Ukuzilolonga kuzisa into entle kuthi. Ukuzivocavoca kuphucula amanqanaba e-Anandamide emzimbeni kwaye ke ukwandisa ukwanda kwakho kokuzivocavoca nzima. Uvavanyo lubonisa ukuba emva kokuzilolonga, baye bazole kwaye bangabinazintlungu. Oku kufanelekile ngenxa ye-CB1 kunye ne-CB2'sCB2's activation ngu-Anandamide. Iyabonakala imizuzu engama-30 yokubaleka ngamandla okanye i-aerobics inyusa kakhulu amanqanaba e-Anandamide kwimizimba yethu. Kukwabonwa ukuba imigraines yezigulana ezithatha i-aerobics zihlala zichacha ngokufanayo. Ngokukodwa kungenxa yamanqanaba aphezulu e-Anandamide aveliswe emzimbeni wabo ngenxa yomthambo onzima.

Ukunciphisa uxinzelelo

Abantu abanokulawula uxinzelelo banenqanaba eliphezulu le-Anandamide kubo. Uxinzelelo luyanciphisa ukusebenza kwe-CB1 kwaye ngenxa yoko kunciphisa amanqanaba e-Anandamide kwaye, nawo, abonise ukunciphisa ukusebenza kwe-cannabinoid. Yiphephe ke imeko yoxinzelelo ukuphucula impilo yonke. Isisombululo sisinye kukucamngca.Ululeko luphucula amanqanaba e-Anandamide kunye ne-dopamine emzimbeni wethu. I-Mediatbodiesleads ikhokelela kumanqanaba aphezulu e-oxytocin ekonyusa amanqanaba e-Anandamide emzimbeni wethu. Kufana nomjikelo olungileyo wentlalontle. I-Anandamide ikunceda ukuba wehlise umoya kwaye ucamngce; Ukucamngca kuqhubela phambili kuphucula amanqanaba akho e-Anandamide kwaye kukunceda ufumane isiqabu kuxinzelelo.

I-Anandamide (AEA) Isisombululo

Njengazo ezinye i-endocannabinoids, idosi engaphantsi yeAnandamide ilungile kuthi. Amanani aphezulu ayingozi kwimizimba yethu. 1.0mg / kg. (ubunzima bomzimba ngamnye (i-Kg nganye) kufanelekileidosi yeAnandamide (AEA). Kodwa ukuba ufumana naziphi na iingxaki, kufuneka ubonane nogqirha ngokukhawuleza. Koomama abakhulelweyo kunye noomama abancancisayo kufuneka babonane noogqirha babo ngaphambi kokuba kusetyenziswe iAnandamide (AEA).

I-Anandamide (AEA) Iziphumo ebezingalindelekanga

I-Anandamide inokunyamezelana okuphezulu kunye neziphumo ebezingalindelekanga ezisezantsi. Unokufumana ubunzima bokwexeshana njengokulahleka kwesisindo, isiyezi, okanye ukugabha. Kwiimeko ezithile, ulawulo lwe-Anandamide (AEA) ngexesha lokuncancisa (kufundwe kwiimpuku zabantu abadala) kukhokelela ekuzuzeni ubunzima, ekuqokeleleni amafutha emzimbeni, nakwi-insulin. Oku kwenzeka ngenxa yokwanda komnqweno okhokelela kukutya okuphezulu.

Ukuthenga iAnandamide (AEA) izongezo

Singakuqonda ngokulula ukuphila ubomi obunempilo i-Anandamide (AEA) kubalulekile. Inceda ekuthinteleni nasekulweni izifo ezahlukeneyo. Ukuthintela ukusilela kwe-Anandamide (AEA), kububulumko ukusebenzisa izongezo kumthamo omiselweyo. Ngokubanzi, iAnandamide (AEA) iyafumaneka kwioyile (70% kunye ne-90%) kunye neefom zePowder (50%). I-China iye yaba ngumlimi ophambili we Anandamide (AEA) isongezelelo.

I-Cannabidiol (CBD) isebenzisa

Oku kulandelayo kukusetyenziswa kwe-cannabidiol;

● Ukunyanga isifo sokuhlutha (ukuxhuzula)

I-Cannabidiol isetyenziselwa ukuphatha ukuxhuzula. I-CBD inokuchaphazela amajelo eseli yeeseli zemithambo-luvo. Into ebalaseleyo kwisifo sokuwa kukuhamba okungaqhelekanga kwesodium ngaphakathi nangaphandle kweeseli. Oku kubangela ukuba umlilo uvuthe ngokungaqhelekanga ukhokelela ekubanjweni. I-CBD ifunyenwe ukunciphisa oku kungahambi ngokungaqhelekanga kwesodium ngenxa yoko kunciphisa ukuxhuzula.

Ezinye iimveliso ze-CBD kubandakanya i-Epidiolex zivunyiwe ukunyanga ukuxhuzula okubangelwa yi-Lennox-Gastaut syndrome, Dravet syndrome, okanye tuber sclerosis complex. Eli chiza likagqirha liyasetyenziswa kunye namanye amachiza okulwa ukuxhuzula ukunyanga ukuxhuzula kubantu abanesifo seSturge-Weber, isifo esosuleleko esinxulumene nokusuleleka, kunye nokuphazamiseka kwemfuza okubangela ukunganyangeki.

Kuphononongo luka-2016 olubandakanya abantu abangama-214 abanesathuthwane, i-CBD yenziwa nge-2 ukuya kwi-5 mg yonke imihla iiveki ezili-12 ukongeza kunyango lwesifo sokuwa. Kwafunyaniswa ukuba abathathi-nxaxheba babenokubanjwa okumbalwa ngenyanga.

● Inokusetyenziselwa ukunyanga umhlaza

Ioli yeCannabidiol ingasetyenziselwa ukunciphisa iimpawu ezinxulumene nomhlaza kunye nemiphumo emibi yonyango lomhlaza njengentlungu, isicaphucaphu kunye nokugabha.

Kuphononongo lwezigulana ezili-16 ezinomhlaza ezifumana ichemotherapy, i-CBD esetyenzisiweyo kunye ne-THC yafunyanwa ukunciphisa iziphumo ezinxulumene nekhemotherapy ezinjengokugabha nokugabha.

Olunye uphononongo lubonakalise ukuba i-CBD ikuthintele ngokufanelekileyo ukwanda komhlaza wamabele kwiimpuku.

● Ibonisa iipropati zokuthintela ukhuseleko

Amandla e-CBD okuphembelela inkqubo ye-endocannabinoid kunye nezinye iinkqubo zokubonisa ubuchopho zenza ukuba kube luncedo kubantu abaneengxaki zemithambo-luvo. Ioyile ye-CBD inokunciphisa ukudumba okunxulunyaniswa nokuphazamiseka kwe-neurodeergenerative.

Uninzi lwezifundo zijolise ekusetyenzisweni kwe-CBD kunyango lweengxaki zemithambo-luvo ezinje ngokuxhuzula kunye ne-multiple sclerosis. Uphando lubonisa ukusetyenziswa kwayo ekunyangeni ezinye iingxaki ezinje ngesifo se-Alzheimer kunye nesifo sika-Parkinson.

Kwisifundo sexesha elide seempuku ezichazwe kwisifo se-Alzheimer, i-CBD yafunyanwa ukuthintela ukwehla kwengqondo.

● Ukunyanga uhlobo lwesifo seswekile

Uhlobo lwe-1 yeswekile luhlobo lwesifo seswekile olwenzeka xa amajoni omzimba ehlasela iiseli zepancreas, oku kubangela ukudumba.

I-CBD ifunyenwe inika iipropathi ezichasayo, inokuthi ithomalalise ukudumba okanye ilibazise ukwenzeka kohlobo lweswekile 1.

Kuphononongo lweempuku ezinesifo seswekile, i-CBD yafunyanwa ikhusela ii-neurons ngokuthintela ukwehla kwengqondo kunye nokunciphisa ukudumba kwentliziyo.

Izibonelelo zeCannabidiol (CBD)

I-Cannabidiol inoluhlu olubanzi lwezibonelelo zonyango.
Apha ngezantsi kukho izibonelelo ze-cannabidiol;

● Inganciphisa uxinzelelo kunye noxinzelelo

I-Cannabidiol (i-CBD) inokunceda ukunciphisa uxinzelelo kunye nokunciphisa iindlela zokuziphatha ezinxulumene noxinzelelo ezinxulunyaniswa neemeko ezinje ngoxinzelelo ngokubanzi, ukuphazamiseka, ukonwaba ekuhlaleni, kunye noxinzelelo lwasemva koxinzelelo (PTSD).

Kuphononongo lweempuku, i-cannabidiol yafunyanwa ibonakalisa zombini uxinzelelo kunye noxinzelelo.

● Ngaba unokuthomalalisa iintlungu

I-CBD ibonelela ngesiqabu kwintlungu yendalo kunamayeza aqhelekileyo.

Imizimba yethu inenkqubo ekhethekileyo ye-endocannabinoid enoxanduva lokulawula ukulala, iintlungu, ukudumba kunye nokuphendula kwamajoni omzimba. Umzimba ke ngoko uvelisa i-endocannabinoids, ii-neurotransmitters ezibophelela kwii-cannabinoid receptors kwinkqubo yakho yeemvakalelo.

I-CBD ibonakalisile ukuba nefuthe kwinkqubo ye-endocannabinoid ngaloo ndlela kunciphisa iintlungu kunye nokudumba.

Ngokudibene ne-THC, ioyile ye-CBD inokusetyenziselwa ukunyanga iintlungu ezinxulumene neemeko ezahlukeneyo ezinjenge-multiple sclerosis, isifo samathambo, iintlungu zesciatic nerve kunye nokwenzakala kwethambo lomqolo.

Kuphononongo lwabantu abane-rheumatoid arthritis, i-CBD esetyenziswe kunye ne-THC yafunyaniswa ukuba iyaziphelisa iintlungu ngexesha lokuhamba kunye nokuphumla kunye nokuphucula umgangatho wokulala kwizigulana.

● Zingawanciphisa amabala

Amabala yimeko yesikhumba echaphazela abantu abaninzi. Isenokuba ngenxa yemfuza, ukudumba, kunye nokuveliswa kakhulu kwe-sebum (into enamafutha eyenziwe ngamadlala asabisayo kulusu).

Uphando lubonisa ukuba i-CBD inokunceda ukunciphisa amaqhakuva ngokwenza njenge-arhente echasayo kunye nokunciphisa imveliso ye-sebum.

Umzekelo, uphononongo lomntu lufumanise ukuba ioyile ye-CBD ikwazile ukuthintela ukuveliswa kakhulu kwe-sebum ngamadlala asebenzayo ngenxa yoko unyango olusebenzayo lwamabala.

● Ngamana unokunceda ukuyeka ukutshaya kunye nokuyeka iziyobisi

I-CBD ngohlobo lwe-inhaler inokunceda abantu abatshayayo ukuba basebenzise iisigarethi ezimbalwa kunye nokunciphisa ukuba likhoboka le-nicotine. Oku kudlala indima ekuncedeni umntu ayeke ukutshaya.

Kwisifundo se-2018 se-CBD saqatshelwa ukunceda ukunciphisa umnqweno wecuba emva kokurhoxa. Kwafunyanwa ukunceda umntu ukuba akhululeke.

I-Cannabidiol (i-CBD) inokubonelela ngezinye izibonelelo kubandakanya;

  • Ngamana unokubanceda abantu abangenabuthongo ukuba bafumane umgangatho kunye nokulala okungaphazamiseki
  • Ngaba unokukukhulula kwintloko ebuhlungu okanye kwimigraine,
  • Ngaba kunokunceda ukunciphisa isicaphucaphu,
  • Unokunceda ekunciphiseni ukwaliwa okanye isifuba
  • Ingasetyenziselwa unyango lweemeko zemiphunga.

I-Cannabidiol (CBD) idosi

Umthamo weoyile ye-Cannabidiol uxhomekeke kuhlobo lolawulo, injongo ekujoliswe kuyo, ubudala, kunye nezinye iimeko ezisisiseko. Ukuba ufuna ukusebenzisa ioyile ye-cannabidiol kuya kufuneka ubonane nogqirha wakho malunga nendlela yokuthatha ioyile ye-CBD ngaphambi kokuba uyifumane ngengcebiso yeengcali malunga nokusetyenziswa ngokufanelekileyo kunye nedosi. Uyithatha njani ioyile ye-CBD iya kuxhomekeka kuhlobo lolawulo kubandakanya;

  • Iipilisi kunye neepilisi zithathwa ngomlomo okanye ngeelwimi ezincinci
  • I-oyile ye-Cbd ithathwa ngomlomo
  • Ioyile ye-Cbd yesicelo eluswini
  • Ukufafaza impumlo ngokuphefumla

Kuba i-cannabidiol intsha kakhulu akukho mgangatho usemgangathweni wokusetyenziswa ngeendlela ezahlukeneyo. Nangona kunjalo, i-FDA ivume ukusetyenziswa kwe-Epidiolex, eyenye yeemveliso ezivela kwi-cannabis. Kuvunyiwe kunyango lwesifo sokuwa kakhulu esibangelwa yi-Dravet syndrome okanye i-Lennox-Gastaut syndrome.

Umthamo ocetyiswayo we-Epidiolex ngolu hlobo lulandelayo:

  • Umthamo wokuqala ngu-2.5 mg / Kg wobunzima bomzimba obuthathwe kabini yonke imihla, usenza idosi eyi-5 mg / kg ngosuku ngalunye.
  • Emva kweveki enye, idosi inokunyuswa iye kwi-1 mg / kg kabini yonke imihla, eyi-5 mg / kg ngosuku.

Ngelixa izibonelelo zeoyile ze-CBD zichaziweyo umntu unokufumana ezinye iziphumo ebezingalindelekanga ze-cannabidiol kubandakanya isicaphucaphu, ukudinwa, urhudo, ukuphelelwa ngumdla wokutya kunye nokucaphuka.

ICannabidiol (CBD) iyathengiswa (Thenga iCannabidiol (CBD) ngesixa)

Ioli yeCannabidiol iyathengiswa ifumaneka ngokulula kwi-Intanethi. Nangona kunjalo, xa ucinga ukuba i-cannabidiol ithenge kumthombo othembekileyo ovunyiweyo wokuthengisa ioyile ye-cannabidiol ukufumana eyona oyile ye-CBD.

Ungajonga uphononongo lwabathengi kwiiwebhusayithi ezininzi ukufumana umthengisi weemveliso ze-CBD othembekileyo onikezela ngeoyile efanelekileyo ye-CBD.

Soloko uthenga i-cannabidiol (i-CBD) ngesixa esikhulu ukonwabela amaxabiso anesaphulelo.

Landela imiyalelo yendlela yokuthatha ioyile ye-CBD ngononophelo ukuthintela ukufumana iziphumo ezinokubakho zeoyile ye-CBD.

Kuyiwaphi thenga i-Anandamide (AEA) ipowder ngobuninzi

Cofttek   imveliso

Eyasungulwa ngo-2008, iCofttek yinkampani ephezulu yokuThengisa ukutya kwiDolophu yaseLuohe, kwiPhondo laseHenan, eChina.

Iphakheji: 25kg / igubu

Ndiyathemba ukuba oku kuyanceda !! Ulinde ntoni emva koko? Fumana iAnandamide ekhaya kwaye wenze ubomi bube lula!

Inqaku ngu: UGqr. Zeng

Isiqendu ngo:

UGqirha Zeng

Umququzeleli, ubunkokheli bobunkokheli kwinkampani; I-PhD ifunyenwe kwiYunivesithi yaseFudan kwi-organic chemistry. Ngaphezulu kweminyaka esithoba yamava kwi-organic chemistry kunye noyilo lweziyobisi synthesis; phantse i-10 lamaphepha ophando apapashwe kwiijenali ezigunyazisiweyo, nangaphezulu kweepatent ezintlanu zase China

Ucaphulo

Imallet PE, uBeninger RJ (1). "I-endo native cannabinoid receptor agonist anandamide impairs memory in rats". I-Pharmacology yokuziphatha. 1996 (7): 3–276

UMechoulam R, uFride E (2). "Indlela engagangathwanga eya kwi-endo native brain i-cannabinoid ligands, i-anandamides". KwiPertwee RG (ed.). Ii-cannabinoid receptors. IBoston: Icandelo leendaba. iphepha. 1995–

(3) .I-Rapino, C.; IBattista, N.; Bari, M.; IMaccarrone, M. (2014). "I-Endocannabinoids njengama-biomarkers okuzala komntu". Ukuhlaziywa koLuntu. 20 (4): 501-516.

(4).(2015). I-Cannabidiol (i-CBD) kunye ne-analogs yayo: uphononongo lwefuthe labo kukudumba. I-Bioorganic kunye neMedical Chemistry, 23 (7), 1377-1385.

ICorroon, J., kunye nePhillips, JA (5). Isifundo esinqamlezileyo saBasebenzisi beCannabidiol. I-cannabis kunye nophando lwe-cannabinoid, 2018 (3), 1-152.

(6).IZiko leLizwe leNgcaciso yeBiotechnology (2020). Isishwankathelo seCompChem Compound seCID 644019, iCannabidiol. Ibuyisiwe ngo-Okthobha 27, 2020, ukusuka .

(7) .R de Mello Schier, A., P de Oliveira Ribeiro, N., S Coutinho, D., Machado, S., Arias-Carrión, O., A Crippa, J.,… kunye no-C Silva, A (2014). Iziphumo zokuthintela uxinzelelo kunye noxinzelelo lwe-cannabidiol: ikhompawundi ye-Cannabis sativa. I-CNS kunye ne-Neurological Disorder-Iithagethi zeZiyobisi (Zangaphambili iithagethi zamachiza-i-CNS kunye nokuphazamiseka kwentliziyo), 13 (6), 953-960.

Intsikelelo, EM, Steenkamp, ​​MM, Manzanares, J., & Marmar, CR (8). I-Cannabidiol njengonyango olunokubakho lokuphazamiseka koxinzelelo. Neurotherapeutics: Ijenali yoMbutho waseMelika wovavanyo lweNeuroTherapeutics12(4), 825-836.

(9).IAnandamide (AEA) (94421-68-8)

(10).Uhambo lokujonga umz.

(11).I-Oleoylethanolamide (oea) -i-wand yemilingo yobomi bakho

(12).Yonke into ofuna ukuyifumana malunga ne-nicotinamide riboside chloride.

(13).Izongezo zeMagnesium l-threonate: izibonelelo, idosi, kunye neziphumo ebezingalindelekanga.

(14).Palmitoylethanolamide (ertyisi): izibonelelo, idosi, ukusetyenziswa, isongezelelo.

(15).Izibonelelo zezempilo ezi-6 eziphezulu ze-resveratrol supplements.

(16).Izibonelelo ezi-5 eziphezulu zokuthatha i-phosphatidylserine (ps).

(17).Izibonelelo ezi-5 eziphezulu zokuthatha i-pyrroloquinoline quinone (pqq).

(18).Olona hlobo longezelelekileyo lwe-alpha gpc.

(19).Olona nyango lulungileyo lokuguga lwenicotinamide mononucleotide (nmn).