INKCAZELO SIMAHLA RADICAL

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Imetabolism yomzimba eqhelekileyo

Ukumoshwa komoya

Imizila ye-Ultraviolet

Ungcoliseko olunzima lwentsimbi

Ungcoliseko lwezibulali zinambuzane

Ungcoliseko lwezibulali zinambuzane

 

 

IIMPAWU ZASEKHAYA NEZIFO

 

Ngokwesiqhelo, ii-radicals zasimahla ziyafuneka kwimizimba, kodwa ukugqithisa okugqithisileyo kunokubangela ukungalingani kokusebenza komzimba, emva koko kukhokelele kuxinzelelo lwe-oxidative oluvela kwizifo ezahlukeneyo (uncwadi lubonisa ukuba iiradicals zasimahla zingumthombo wezifo ezahlukeneyo).

 

 

 

 

ISIQINISEKISO

 

Imizimba yethu ayinakho ukusebenza ngaphandle kweoksijini, kwaye nje ukuba inani elikhulu lamahhala e-radicals lenyuke, umzimba ophantsi koxinzelelo lwe-oxidative uya kubangela ukuba inkqubo yokulungisa ihluleke ekususeni i-radicals yamahhala. Kwiimeko ezizodwa, umzimba kufuneka uzalise ii-antioxidants in vitro ukususa iiradicals ezigqithileyo simahla.

 

UPHUHLISO LWEZITHUTHI

 

 

L-ERGOTHIONEINE -UHLOBO OLUTSHA LWE-ANTIOXIDANT YENDALO

 

I-EGT yi-chiral yendalo i-amino-acid antioxidant biosynthesized kwiibhaktheriya ezithile kunye nefungi. Yindibaniselwano ebalulekileyo ye-bioactive esetyenzisiweyo njengesikrelemnqa esiqwengayo, isicoci se-ray ye-ultraviolet, umlawuli weempembelelo zokunciphisa i-oxidation kunye ne-bioenergetics yeselula, kunye ne-cytoprotector yomzimba, njl.
I-L-Ergothioneine (i-EGT, i-ERGO, i-CAS: 497-30-3), ekwabizwa ngokuba yi (S) -cy-Carboxy-2,3-dihydro-N, N, N-trimethyl-2-thioxo-1H-imidazole- I-4-ethanaminium yangaphakathi yetyiwa, yaqala ukukhutshwa kwi-ergot nguTanret C ngo-1909, emva koko kwafunyanwa negazi lesilwanyana. I-EGT ecocekileyo yikristale emhlophe, inyibilika emanzini, (inyibilikisiwe i-0.9mol / L kubushushu begumbi). I-Autoxidation ayinakwenzeka kwixabiso le-pH yemvelo okanye kwisisombululo esomeleleyo se-alkali. I-EGT inokubakho kwiifom ezimbini ze-isomer - ifom ye-thiol kunye nefom ye-thione, njengoko kubonisiwe ngezantsi:

 

 

 

ISIQINISEKISO

Ngezibonelelo zemisebenzi emininzi, I-EGT ime phakathi kwezinye ii-antioxidants ezininzi.

 

 

IINDLELA

Ngezibonelelo zemisebenzi emininzi, i-EGT ibonakala phakathi kwezinye izinto ezininzi antioxidantsIzibonelelo (ngokuthelekiswa ne-glutathione, cysteine ​​njl.):
I -EGT ilula kakhulu ukuqokelela kwiiseli kwaye uxinzelelo luzinze ngakumbi ezinye i-antioxidants.
-I-EGT isebenza ngakumbi ekunciphiseni ukufa kweseli okubangelwa yipyrogallol.
I -EGT ikakhulu ityhoboza i-ROS ukuthintela i-oxidation, ngelixa i-glutathione kunye nezinye ziqhekeza i-radicals yasimahla, Oko kukuthi, enye antioxidants hlamba iimveliso ze-oxidation.(1) Oleoylethanolamide (oea) –i-wand yomlingo yobomi bakho

UMBULELO WOKUZIPHATHA

iziphumo: I-EGT ibingoyena mlingisi osebenzayo wee-radicals zasimahla xa kuthelekiswa ne-antioxidants zakudala njenge-GSH, i-uric acid kunye ne-trolox. Ngokukodwa, amandla aphezulu e-antioxidant aboniswe yi-EGT vs peroxyl radicals abangele i-25% ephezulu kunexabiso elifunyenwe ngereferensi ye-antioxidant trolox. Umthamo wokwehla kwe-EGT ngokubhekisele kwi-radicals ye-hydroxyl yayingama-60% ngaphezulu, xa kuthelekiswa ne-uric acid, emele ireferensi antioxidant vs hydroxyl radicals. Okokugqibela, i-EGT ibonakalise owona msebenzi uphezulu we-antioxidant ukuya kwi-peroxynitrite, ene-10% ephezulu kunaleyo ye-uric acid.

 

 

 

EMINYE IMISEBENZI

 

I-EGT ineempembelelo kulawulo lwe-intracellular energy,

ukonyusa ukungazinzi,

ukuphucula inqanaba lokusinda kwesidoda,

ukukhusela isibindi ekonzakaleni,

ukuthintela usulelo,

i-neurodegeneration,

iziphene zophuhliso kunye nekati.

 

 

UKUFUNEKA KOPHUHLISO

① I-EGI IBONAKALISIWE KAKHULU KWIZITHILI NEZILWANYANA

 

② IMIYALELO

5-10mg ngeyunithi yabantu abadala kunye neeyunithi ezi-2-3 zokutya okokoko kubalulekile ekutyeni kwakho kwemihla ngemihla.

Umthombo: Li Yiqun, Zhou Nianbo. Imisebenzi ye-Biology kunye nokusetyenziswa kwe-EGT [J]. Ubunjineli bokutya, 2010 iim9 （3） ： 26-28.

Ukungeniswa kudweliswe ngolu hlobo lulandelayo:

Abantwana (iminyaka emi-3 ukuya kwe-11) ≤l 0 mg / usuku
Ulutsha (iminyaka eli-11 ukuya kwelama-21） ≤30 mg / usuku
Abantu abadala (iminyaka engama-21-80) ≤30 mg / usuku

Qaphela: 1. Imithamo yabantwana kunye nabantu abadala （iminyaka emi-3 -80 ubudala）

           Ukusetyenziswa kwabasetyhini abakhulelweyo okanye abancancisayo akukhuthazwa.

Umthombo wedatha: I-Tetrahedron xa ufaka isicelo se-US NDI

Idatha iphakamisa ukuba: 10.5mg / g ye-OXIS's ADI (eyamkelekileyo imihla ngemihla).

 

Y UBULUNGISA

 

 

UKUTHATHA NESICELO

(1) ICANDELO

Okwangoku, zintathu iindlela zokuvelisa i-EGT: endalo Ukukhupha i-bio (ikakhulu amakhowa, izicwili zezilwanyana kunye nokutsalwa kwegazi), kunye nendlela ye-biosynthesis.

Thelekisa ukukhutshwa kwe-EGT tindlela

(2) UKUSETYENZISWA

I-EGT inezicelo ezibanzi kwizithambiso, ukutya okusebenzayo, amayeza, amayeza, i-biomedicine, njalo njalo.

(3) EZINYE IZICELO EZIFUMANEKAYO

Ucaphulo

  1. I-Oleoylethanolamide (oea) -i-wand yemilingo yobomi bakho
  2. I-Anandamide vs cbd: yeyiphi engcono kwimpilo yakho? Yonke into ekufuneka uyazi ngabo!
  3. Yonke into ofuna ukuyifumana malunga ne-nicotinamide riboside chloride
  4. Izongezo zeMagnesium l-threonate: izibonelelo, idosi, kunye neziphumo ebezingalindelekanga
  5. Palmitoylethanolamide (ertyisi): izibonelelo, idosi, ukusetyenziswa, isongezelelo
  6. Izibonelelo zezempilo ezi-6 eziphezulu ze-resveratrol supplements
  7. Izibonelelo ezi-5 eziphezulu zokuthatha i-phosphatidylserine (ps)
  8. Izibonelelo ezi-5 eziphezulu zokuthatha i-pyrroloquinoline quinone (pqq)
  9. Olona nyango lwe-alpha gpc
  10. Olona nyango lulungileyo lokuguga lwenicotinamide mononucleotide (nmn)

 

Inqaku ngu: UGqr. Zeng

Isiqendu ngo:

UGqirha Zeng

Umququzeleli, ubunkokheli bobunkokheli kwinkampani; I-PhD ifunyenwe kwiYunivesithi yaseFudan kwi-organic chemistry. Ngaphezulu kweminyaka esithoba yamava kwi-organic chemistry kunye noyilo lweziyobisi synthesis; phantse i-10 lamaphepha ophando apapashwe kwiijenali ezigunyazisiweyo, nangaphezulu kweepatent ezintlanu zase China

 

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