Kutheni sifuna iNicotinamide Riboside Chloride

Umzi mveliso wezithambiso lushishino lweebhiliyoni zeedola, ikakhulu kuba abantu bayikhathalele indlela abajongeka ngayo. Esi sesona sizathu siphambili sokuba kutheni uphando malunga nezinto ezichasene nokwaluphala kunye neemveliso zenze inkqubela phambili emangalisayo ngexesha elifutshane. Amahlakani ehlabathi jikelele ayaqonda ukuba kukho imali eyenziweyo ngomnqweno wabantu ngabanye wokuhlala umncinci ngonaphakade kwaye ngenxa yoko, babe namaqela endaweni, bechitha iintsuku kunye neeveki ukufumana izithako kunye neemveliso ezinokuphucula amandla olusu. INicotinamide Riboside okanye iNiagen yafunyanwa ngenxa yolu phando lungagungqiyo kwiimveliso ezichasene nokwaluphala. Ngelixa uninzi lwezinto ezichasene nokwaluphala zinciphisa iimpawu zokuguga kulusu, iNiagen inciphisa imiqondiso yokuguga emzimbeni. INicotinamide Riboside okanye iNiagen yifristal ye INicotinamide Riboside Chloride kwaye kanye ngaphakathi emzimbeni, iguquka ibe yi-NAD +, enoxanduva lokuguga okunempilo kunye neminye imisebenzi ebalulekileyo. 

Kweli nqaku, sigubungela yonke imiba yeli candelo limangalisayo, kubandakanya izibonelelo zalo, iziphumo ebezingalindelekanga kunye nedosi efanelekileyo.

 

Yintoni uNicotinamide Riboside Chloride?

I-Nicotinamide Riboside Chloride okanye i-Niagen yindawo ye-crystal yeNicotinamide Riboside, eyi-NAD + eyandulelayo yevithamini. Ngelixa iNicotinamide Riboside inobunzima be-255.25 g / mol, iNicotinamide Riboside Chloride inobunzima abangama-290.70 g / mol kunye ne-100 mg yeNicotinamide Riboside Chloride ibonelela ngama-88 mg eNicotinamide Riboside. I-NR ithathwa njengekhuselekileyo ukuba isetyenziswe ekutyeni.

Nangona iNicotinamide Riboside iluhlobo lweVitamin B3, iipropathi zayo ezohlukeneyo zenza ukuba zahluke ngokupheleleyo kwamanye amalungu eqela leevithamini B3, ezinjenge-nicotinamide kunye niacin. Ngelixa i-Niacin ibangela ulusu ukuba lugungxule ngokuvula i-GPR109A G-protein edityanisiweyo, uNicotinamide Riboside akaphenduli konke konke ngeli receptor kwaye ke oko akubangeli kushushubetha kolusu, kwanaxa kuchithwe umthamo omkhulu we-2000 mg ngosuku. Ngapha koko, iimvavanyo ezenziwa kwiimpuku zatyhila ukuba iNicotinamide Riboside yindawo eyandulelayo ye-NAD + ekhokelela kwisikhephe esiphezulu kwiNicotinamide Adenine Dinucleotide okanye i-NAD + emzimbeni. 

I-Nikotinamide Riboside iyenzeka ngokwemvelo kwindawo yokutya yomntu kwaye kanye ngaphakathi komzimba, iyatshintsha ibe yi-NAD +, ekufuneka umzimba usebenze kuyo imisebenzi eyahlukeneyo. Umzekelo, uphando lwenzululwazi lufakazele ukuba iNicotinamide Riboside Chloride okanye i-NAD + ebonelelwe yi-NR iphucula ukusebenza kwe-mitochondrial kunye nokuziva kwe-insulin ngokwenza iseti ye-mestuin ye-enzyme, enoxanduva lokulawula i-oxidative metabolism emzimbeni.

Ukuza kuthi ga ngoku, zintlanu izifundo ezenziweyo ukufunda ukhuseleko kunye nokusebenza kweNicotinamide Riboside kwaye zonke ezi zifundo ziye zafumanisa ukuba icandelo likhuselekile ukusetyenziswa ngabantu.

 

INicotinamide Riboside Chloride benefits

Ngaphambi kokuba sixoxe nge Izibonelelo zeNicotinamide Riboside Chloride, kubalulekile ukucacisa ukuba i-Nikotinamide Riboside Chloride yile ityiwa apho ifunyenwe iNicotinamide Riboside, izibonelelo zeNicotinamide Riboside Chloride ziyafana nezibonelelo zeNicotinamide Riboside.

 

INicotinamide Riboside Chloride inyusa ukuKhula kweMpilo

I-NAD + eyenziwe yasebenza nguNicotinamide Riboside Chloride ngaphakathi komzimba isebenzisa ii-enzymes ezithile ezihambelana nokuguga okunempilo. Enye ye-enzyme enjalo yi-sirtuins, edityaniswe nobomi obuphuculweyo kunye nobomi bezilwanyana. Izifundo zesayensi zibonakalise ukuba i-sirtuins iphucula umgangatho wobomi kunye nobomi obude ngokunciphisa ukuvuvukala, ukuphucula izibonelelo ezihambelana nokuthintela kwekhalori kunye nokulungiswa kweDNA eyonakalisiweyo. I-NAD + eyenziwe yasebenza nguNicotinamide Riboside Chloride nayo isebenzisa ii-polymerase zepaseji ezaziwayo ukulungisa iDNA eyonakeleyo. Ukongeza, izifundo ezininzi zesayensi zidibanise umsebenzi weepolymerases kunye nobomi obuphuculiweyo. 

 

Iyanciphisa amaThuba amaNtu okuphuhlisa izifo zeNtliziyo

Ukwaluphala kwandisa amathuba okuba nesifo sentliziyo. Njengokuba abantu bekhula ubudala, imithambo yegazi iya isiba nkulu kwaye iqine, ethi yona ikhokelele kunyuko lwegazi. Xa uxinzelelo lwegazi ngaphakathi kweenqanawa lonyuka, intliziyo kufuneka isebenze nzima ngakumbi ukumpompa igazi, oko kukhokelela kwizifo ezahlukeneyo zentliziyo. I-NAD + ebonelelwe yiNicotinamide Riboside Chloride iyawuguqula utshintsho olunxulumene nobudala obubangelwa yimithambo yegazi. Kukho ubungqina obuninzi benzululwazi bokubonisa ukuba iNicotinamide Adenine Dinucleotide okanye i-NAD + ayinciphisi kuphela ukuqina kwesitya segazi kodwa ikwalawula uxinzelelo lwegazi lwe-systolic.

 

INicotinamide Riboside Chloride Ikwabonelela ngokhuseleko kwiiseli zeBongo

INicotinamide Riboside ikhusela iiseli zobuchopho. Uphononongo olwenziwe kwiimpuku luveze ukuba imveliso ye-NAD eyenziwe nge-NAD + inyuse imveliso ye-PGC-1 alpha protein ukuya kuthi ga kwi-50%. Iprotein ye-alpha ye-PGC-1 inceda ukukhusela iiseli zobuchopho ngokuchasene noxinzelelo lwe-oxidative kunye nokuphucula ukusebenza kwe-mitochondrial. Kungenxa yoko, ukusetyenziswa kwe-NR ebantwini kukhusela kwizifo ezibangelwa bubudala beengqondo, ezinje nge-Alzheimer's kunye neParkinson's. Olunye uphononongo oluthile lwafunda isiphumo samanqanaba e-NAD + kubantu abaneParkinson's. Uphononongo luphelile ukuba i-NAD + iphucule umsebenzi we-mitochondrial kwi-cell stem.

 

Ezinye izibonelelo eziphambili zeNicotinamide Riboside Chloride

Ngaphandle kwezibonelelo kuxutyushwe ngazo ngasentla, Nazi ezinye izibonelelo ezongeziweyo ezinxulumene neNicotinamide Riboside Chloride.

  • I-NR yaziwa njengokonyusa amandla emisipha, ukusebenza kunye nokunyamezelana kwaye ke, ukusetyenziswa kwe-NR kudityaniswa nokusebenza okungcono kwembaleki.
  • Njengoko kuchaziwe ngentla, ukuveliswa kwe-NAD + yokulungisa i-NAD + kulungisa i-DNA eyonakeleyo kunye nokubonelela ngokhuseleko kuxinzelelo lwe-oxidative. Oku kuthi, kunciphise amathuba okuba nomhlaza.
  • Isifundo sihlalutye isiphumo seNicotinamide Riboside kwi-metabolism kumagundane. Uphononongo lwagqiba ukuba i-NR yonyusa imetabolism kwiimpuku. Nangona ubungqina obungaphezulu bezesayensi bufuneka malunga noku, izazinzulu ezininzi zikholelwa ukuba iNicotinamide Riboside inokuba nefuthe elifanayo ebantwini kwaye ke, kufanele ukuba luncede ngokunciphisa umzimba.

INicotinamide Riboside Chloride

I-Nicotinamide Riboside Chloride Dosage

Izifundo ezintlanu ezenziweyo ukuza kuthi ga ngoku zifumene ukuba iNicotinamide Riboside ikhuselekile ukusetyenziswa ngabantu. Nangona kunjalo, ezi zifundo zimisele ukhuseleko INicotinamide Riboside Chloride umyinge Umda kubantu abaphakathi kwe-1,000 2,000 ukuya kwi-XNUMX mg ngosuku. Nangona kunjalo, kufuneka igcinwe engqondweni ukuba zonke izifundo ezihlalutya ukhuseleko lweNicotinamide Riboside zazinesampulu elincinci kakhulu kwaye, ngenxa yoko, uphando ngakumbi luyafuneka kule ndawo. 

Eyona njongo iphambili yeNicotinamide Riboside Chloride kukubonelela ngeNicotinamide Riboside Chloride okanye iNiagen emzimbeni. I-Niagen okanye i-NR ihlala ifumaneka ngeendlela ezimbini: iitafile kunye neepilisi. Uninzi lwabavelisi abongezelelweyo beNicotinamide Riboside badibanisa i-NR kunye nezinye iikhemikhali, ezinjengePterostilbene. Ngayiphi na imeko, ukuze uphephe, uninzi lwabavelisi abongezayo bancomela ukugcina ukubethelwa imihla ngemihla kwe-NR phakathi kwama-250 ukuya kuma-300 mg ngemini.

 

Ngaba ikhuselekile iNicotinamide Riboside Chloride?

Izifundo ezininzi ezenziweyo ukuza kuthi ga ngoku zifumene ukusetyenziswa kweNicotinamide Riboside kuluhlu lwe-1000 ukuya ku-2000 mg ngosuku olukhuselekileyo ukuze lusetyenziswe ngabantu. Nangona kunjalo, kuba izifundo ezingaphezulu zekhonkrithi ziyafuneka kule ndawo, abenzi beNicotinamide Riboside bancomela ukugcina ukutya kwakho kwemihla ngemihla kwe-NR phantsi kwama-250-300 mg ngosuku.

Nangona i-Nicotinamide Riboside okanye i-Nicotinamide Riboside Chloride yokusetyenziswa ikhuselekile, inokukhokelela kwiziphumo ebezingalindelekanga ezifana nesicaphucaphu, intloko ebuhlungu, ukuqunjelwa, ukudinwa kunye norhudo. Ukuba ufumana ezinye zeempawu ngelixa uthatha isongezelelo se-NR, ngoko nangoko qhagamshelana nogqirha wakho. Ngapha koko, ekubeni kungekho bungqina baneleyo malunga nefuthe leNicotinamide Riboside kwabasetyhini abakhulelweyo nabancancisayo, eli qela kufuneka liye kude nokusetyenziswa kwezincedisi zeNicotinamide Riboside. 

 

INicotinamide Riboside Chloride shicilelo

Ukuba ufuna imifuno INicotinamide Riboside Chloride zongezaSincoma uTru Niagen Nicotinamide Riboside supplement. Esi songezelelo sisebenzisa i-NIAGEN, imveliso yelungelo elilodwa lomenzi wenkampani yeNR. Inkampani yokuvelisa ijongana kuphela nezongezelelo zeNicotinamide Riboside kwaye ke, umntu unokuqiniseka ukuba izongezo ezenziwe yinkampani zikumgangatho ophezulu kakhulu. Isongezelelo seTru Niagen Nicotinamide Riboside sifika njengee-capsule ekulula ukuzisebenzisa, ekulula ukuziginya. Abasebenzisi bayacelwa ukuba bathathe iphilisi enye kuphela ngosuku.

Nangona kunjalo, ukuba ufuna i-gluten, iqanda, i-BPA, amandongomane, izinto zokulondoloza kunye nemveliso engena-bisi, sicebisa ukubeka imali yakho kwi-Thorne ResveraCel Nicotinamide Riboside supplement. Esi songezelelo sidibanisa i-NR kunye ne-flavonoids. Ngokudibeneyo, ezi zinto zimbini zenza umsebenzi we-sirtuin. Okubaluleke ngakumbi, iTrne ResveraCel ibanga ukuba yenza imijikelo emine yovavanyo kwisongezelelo sayo ngasinye kwaye ke, izongezo zenkampani zikhuselekile ngokugqibeleleyo. Ukongeza, ezi zongezelelo ziveliswa kwindawo eqinisekisiweyo ye-cGMP e-United States nakwiziko eliqinisekisiweyo le-TGA e-Australia.

INicotinamide Riboside Chloride

Ungayithenga phi INicotinamide Riboside Chloride Umgubo ngobuninzi?

Imfuno yezongezo zeNicotinamide Riboside inyuke kakhulu kule minyaka imbalwa idlulileyo, ikakhulu ngoba uNicotinamide Riboside unezibonelelo ezininzi. Ukuba ujonge ukuthengisa kwimarike yezixhasi zeNicotinamide Riboside, into yokuqala ekufuneka uyenzile kukuzifumana umthengisi onomdla othembekileyo nonokuthenjwa. Kuyiwaphi kuthenga INicotinamide Riboside Chloride umgubo ngobuninzi? Impendulo yile Cofttek.

I-Cofttek ngumthengisi wezinto eziluhlaza okhoyo wabakho ngonyaka ka-2008 kwaye malunga neshumi leminyaka, inkampani ibusungule ubukho bayo kumazwe aliqela. Ngaphandle kokuvelisa iimveliso ezinokuthenjwa, inkampani igxilwe kwakhona ekwenzeni inkqubela phambili kwicandelo le-biotechnology, itekhnoloji yeekhemikhali kunye nokuvavanywa kweekhemikhali. Inkampani ikwazibophelela kuphando olusemgangathweni, olunika umngeni ngaphezulu kwabanye abathengisi kwimarike. I I-Nicotinamide Riboside Chloride powder  ebonelelwe yinkampani iza iibatch ze25 kgs kwaye inokuthenjwa ngomgangatho. Ngaphezu koko, inkampani inentengiso ebalaseleyo kunye neqela lokuxhasa abathengi abaya kuthi banakekele zonke iimfuno zakho kunye nemibuzo ngexesha langempela. Oku, ukuba ufuna ukuthenga i-Nicotinamide Riboside Chloride powder ngobuninzi, thembela kwiCofttek kuphela. 

 

Ucaphulo
  1. UConze, D., uBrenner, uC. NoKruger, uKhuseleko lwe-CL kunye neMetabolism yoLawulo lwexesha elide le-NIAGEN (Nicotinamide Riboside Chloride) kwi-Randomized, Double-Blind, Placebo-controlled Contro-Clinical Trial of Healthy Overweight Adult. Sci Rep9, 9772 (2019)
  2. UCarlijn ME Remie, uKay HM Roumans, uMichiel PB Moonen, uNiels J Connell, uBas Haskes, uJulian Mevenkamp, ​​uLucas Lindeboom, uVera HW de Wit, Tineke van de Weijer, Suzanne ABM Aarts, uEsther Lutgens, u-Bauke V Schomaker, uHungung L Elfrink, URubén Zapata-Pérez, uRiekelt H Houtkooper, uJohan Auwerx, uJoris Hoeks, uVera B Schrauwen-Hinderling, uEsther Phielix, uPatrick Schrauwen, uNicotinamide riboside supplementation alters body composition kunye nomzimba wamathambo acetylcarnitine ogxila ebantwini abatyebileyo, I-American Journal of Clinical Nutrition, Umqu. 112, Imagazini 2, Agasti 2020, iphepha 413-426
  3. Elhassan, YS, Kluckova, K., Fletcher, RS, Schmidt, MS, Garten, A., Doig, CL, Cartwright, DM, Oakey, L., Burley, CV, Jenkinson, N., Wilson, M., uLucas , S., Akerman, I., Seabright, A., Lai, YC, Tennant, DA, Nightingale, P., Wallis, GA, Manolopoulos, KN, Brenner, C,… Lavery, GG (2019). I-Nicotinamide Riboside Augions i-Aged Human Skeletal Muscle NAD + Metabolome kunye ne-Induces Transcripttomic kunye ne-Anti-inflammatory Sign. Iingxelo zeeseli28(7), 1717-1728.e6.
  4. I-Nicotinamide Riboside Chloride powder

 

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