Yintoni i OLEOLELEANTHAMOLAMIDE (OEA)?

I-Oleoylethanolamide yenziwe ngamagama amathathu: i-oleoyl, i-ethanol kunye ne-amide. Ukuze kube lula kuthi, siyithumela kwi-OEA ngokufutshane. Kukwaziwa nangokuthi yi-oleothanolamine.

Yindalo ye-ethanolamide lipid esebenza njengomlawuli malunga nenkqubo yokondla kunye nobunzima bomzimba kuzo zonke iintlobo zezilwanyana ezinomqolo. Yimetabolite ye-oleic acid eyakhiwe emathunjini amancinci emzimbeni womntu. Iqhotyoshelwe kwi-PPAR Alpha receptor enceda ukulawula izinto ezine: indlala, amanqatha omzimba, icholesterol kunye nobunzima. I-PPAR Alpha ithetha ukuba iPeroxism Proliferator-activated Receptor Alpha.

 

UKUSEBENZA KWE-OLEOYLETHANOLAMIDE (OEA)

I-OEA okanye iOleoylethanolamide sisiyobisi esikunceda ukulawula ubunzima, ukutya, kunye necholesterol. Yimetabolite yendalo. Ilawula amanqatha omzimba wakho ngokwandisa imetabolism yamanqatha akhoyo emzimbeni wakho. Isebenza ngendlela enomdla kakhulu.

Njengokuba usitya ukutya, eli chiza liya kuthumela umqondiso kwingqondo yakho likucela ukuba uyeke ukutya okanye uthathe okunye ukutya njengoko umzimba wakho sele uthathe ukutya okwaneleyo kwaye awusafuneki. Ngaloo ndlela, uya kuqala ukuziva ukuba ugcwele kwaye ke uyeke ukutya. Ke, ngokuthe ngcembe uyaqhubeka nokuthatha ubuninzi bokutya ixesha ngalinye rhoqo. Ke, ekuhambeni kwexesha, unako ukunciphisa ubunzima obukhulu.

 

ISITHEMBISO

Iziphumo zokusebenza kwe-OEA kunye nezinto ezixhamlayo zafunyanwa kwiminyaka engamashumi amahlanu eyadlulayo. Kwakungekho uphando olunzulu nolucwangcisiweyo malunga ne-OEA ngaphambi konyaka ka-2001. Ngabaphandi abavela eSpain abaqala ukufunda nge-OEA, bavavanywa kwiigundane ukuze bafumane iziphumo. Uphononongo luthi i-OEA ayinasiphumo sibi ebuchotsheni kodwa inokutshintsha indlela otya ngayo kwaye inefuthe kwindlela yokuziphatha yendlala.

I-molecular formula yiC2OH39NO2. Inombolo ye-CAS eyahlukileyo ngu-111-58-0. I-OEA yindibaniselwano ye-oleic acid kunye ne-ethanolamine. Phambi kwamafutha atyebileyo akhoyo kwinxalenye ephezulu yamathumbu amancinci emzimbeni wethu yindawo apho kwenziwa khona la malungu mabini. I-OEA ifana kakhulu kwaye iyafana ne-endocannabinoid anandamide kodwa kungcono ngakumbi.

 

IZIBONELELO ZE-OLEOYLETHANOLAMIDE (OEA)

I-OEA sisiyobisi sokwenene esikhoyo kwimarike. Ezi zilandelayo zezona zibalulekileyo Izibonelelo ze-OEA.

 

1. UKUNCIPHA INQANABA LEGHRELIN

IGhrelin yihomoni efumaneka emzimbeni wethu evuselela umdla wokutya. Kufunyenwe ukuba i-OEA iyanceda ukunciphisa eli nqanaba lehomoni emzimbeni wethu ukuba le OEA ilawulwa.

 

2.UNCIPHA AMANQAKU EMZIMBA NGAMAZWE AYANDAYO

Le naliti ifunyenwe isebenza ngokukuko ekunciphiseni amanqatha omzimba kwaye nawo kwinqanaba elandayo. Iyonyusa ifuthe lemetabolism ye-mitochondria. Icutha nokutya ukutya ngendlela efanelekileyo kwaye inyusa nenqanaba lamandla emzimbeni wakho.

OLEOLELEANTHAMOLAMIDE

3.QINISEKISA IPHEPHA LOKUGCINA IPHEPHA ELIPHANTSI

I-Peptide YY yincindi yedlala evuselela umdla wokutya. Inaliti ye-OEA ukuba ithathiwe iya kunceda ukunciphisa kunye nokugcina inqanaba le-Peptide YY inqanaba lehomoni liphantsi.

 

4.UNCEDA UKULAWULA UKUDLA

Ukuthatha inaliti ye-OEA kuya kunceda ukulawula ukutya ngokunciphisa indawo enamafutha emzimbeni wethu. Ikwonyusa ukutshiswa kwamafutha aqokelelene emzimbeni wethu. Njengokuba usitya ukutya, i-OEA iqala ukusebenza. Iphakamisa inqanaba lokusebenza kwayo kwaye kwangaxeshanye inciphisa inqanaba lokutya ngokuthumela imiqondiso kwingqondo kwaye ikwazise ukuba wanelisekile kwaye awufuni kutya.

 

IZIPHUMO EZINGEKHO

Emva kokuphononongwa kwe-OEA, kuye kwafunyaniswa ukuba akukho mntu ukhe wajongana neziphumo ebezingalindelekanga emva kokuyifaka emzimbeni. I-OEA yi-oleic acid ethathwa njengenxalenye yokutya okusempilweni kunye nokutya okunesondlo.

 

IZIPHUMO EZILUNGILEYO KWI-ANXIETY

I-OEA ichaphazela ngokuqinisekileyo uxinzelelo. Ukufakwa kwe-OEA kunceda ukugcina ingqondo yakho ikhululekile kuxinzelelo kwaye ke inceda ekugcineni izifo ezinengxaki yokuxhalaba.

 

7. YENZA I-HDL EMZIMBENI

Zimbini iintlobo zecholesterol emzimbeni wethu. Zizo- i-LDL Cholesterol kunye ne-HDL Cholesterol. I-LDL yi-cholesterol embi kwaye i-HDL yi-cholesterol efanelekileyo. Ukungeniswa kwe-OEA kunceda ukunciphisa i-LDL Cholesterol kunye nokunyusa i-HDL Cholesterol.

 

8.INTSHOLONGWANE KAGAWULAYO ​​KUMZIMBA WOKWAKHA

Ukwakha umzimba wakho ukwimo efanelekileyo kunye nolwakhiwo kwaye ngokulandelelana yenye yeefashoni zakutshanje kwihlabathi lanamhlanje. Ingakumbi kwimveliso yefashoni okanye yolonwabo kumzimba womzimba ifunwa kakhulu. Ukungeniswa kwe-OEA kukwaluncedo ekwakheni umzimba njengoko wehlisa amanqatha emzimbeni wakho.

OLEOLELEANTHAMOLAMIDE

UKULINGANISWA KWE I-OLEOYLETHANOLAMIDE (OEA)

Ubungakanani be-OEA ingathathwa ngeendlela ezimbini ngokusekwe kwiingcebiso zikagqirha:

 

I-OEA ithathe ngaphandle kokunye ukuncitshiswa kobunzima

Ukuba i-OEA capsule ithathwa ngaphandle kokuncitshiswa kobunzima, unokufumana i-OEA capsule eyi-1mg.

 

I-OEA ithathe nolunye unciphiso lokunciphisa umzimba

Ukuba i-OEA capsule ithathiwe kunye nolunye unciphiso lokunciphisa ubunzima unokuthatha i-1 OEA capsule ye-100 mg ukuya kwi-150 mg.

Umntu kufuneka athathe i-OEA capsule imizuzu engamashumi amathathu ngaphambi kokutya. Oku kuyakukugcina woneliseka ngakumbi ngelixa usitya kwaye ke uyakugcina utya inani elincinci lokutya.

Ngaphezu koko, unokunyusa okanye unciphise inqanaba ledosi yemihla ngemihla ye-OEA ngokusekwe kubunzima bomzimba wakho. Masithi, umntu onobunzima be-150 lb uthatha i-OEA capsule ye-100mg. Kodwa ukuba umntu unobunzima be-250 lb, angathatha i-OEA capsule ye-180 mg.

 

UKUSETYENZISWA KWE I-OLEOYLETHANOLAMIDE (OEA)

Ukusetyenziswa kwe-OEA kusebenze ngendlela ecwangcisiweyo. Okokuqala, yonyusa umsantsa ngexesha phakathi kwesidlo esinye ukuya kwisidlo esilandelayo. Okwesibini, iyanceda ekunciphiseni ukuhla nokujikeleza kwe-circadian. Okwesithathu, ilawulwa zizakha-mzimba ezikhoyo.

OLEOLELEANTHAMOLAMIDE

INKXASO ZENDALO I-OLEOYLETHANOLAMIDE (OEA)

I-OEA ine-oleic acid. Ke, ukutya okuqukethe i-asidi ye-oleic sisiseko ngqo kunye nomthombo wendalo we-OEA. Ioyile yemifuno enjengeoyile ye-olive, i-canola oyile, ioyile kajongilanga ine-oleic acid yendalo izongezo ze-OEA. Unokufumana i-oleic acid kwiinkukhu, itshizi, inyama, kunye neoyile ye-nut nazo zizongezo zendalo ze-OEA. Unokufumana i-oleic acid kubisi lwebele kwaye ke iintsana ezisandul 'ukuzalwa kufuneka zincanciswe ixesha elide kangangoko kunokwenzeka.

Kodwa ingxaki kukuba umyinge wokukhutshwa kwe-OEA kukutya kwendalo kusezantsi kakhulu. Ngaphezulu komndilili ulinganisa i-15: 1, engonelanga kwaphela ukuhlangabezana neemfuno zabathengi behlabathi. Ukukhutshwa kwenqanaba le-OEA kungonyuswa kodwa iindleko zokwenza njalo ziya kuba phezulu kangangokuba zonke ziya kukhokelela kulilize. Ke, phantse ukuba phantse akunakwenzeka ukuvelisa ubunzima be-OEA kwiindlela zendalo.

Ke, okokuqala i-OEA ikhutshwe kwi-oleic acid. Emva koko isetyenziselwa ukuba ngumanduleli weN-oleoylphosphatidylethanolamine. Inyathelo elilandelayo libandakanya ukwahlulwa yi-N- acylphosphatidylethanolamine -i-phospholipase D (PLD) yokuhambisa I-OLEOYLETHANOLAMIDE (OEA).

 

UMBONELELI WOKWENZIWA KWEENKONZO ZE-RAW I-OLEOYLETHANOLAMIDE (OEA)

Umntu unokuthenga iyeza le-OEA kwivenkile ethengisa iziyobisi eyaziwayo efumaneka kufutshane nendawo ohlala kuyo okanye unokuyithenga ngoku-odola kwi-Intanethi. Kodwa umntu kufuneka alumke kakhulu kule nkalo njengoko bonke abathengisi beli chiza bengenakuba yinyani.

Ke, soloko ujonga igama kunye nobuchule be- kwiivenkile zeziyobisi ezikwi-intanethi kwaye ngenxa yoko, kusoloko kuyacetyiswa ukuba ugqithe kwiinkcukacha zokuphononongwa kwabathengi abanamava. Qiniseka malunga nokupakishwa kwemveliso ngokungathi itywinwe ngokufanelekileyo okanye ayiphephi naluphi na uhlobo lokungcola olunokubangela imicimbi ethile eyingozi ngaphambili kwezempilo.

 

I-OLEOYLETHANOLAMIDE (OEA) KWIFOMU YOMGUBO

I-OEA kwimeko yayo yoqobo ayifumaneki ngohlobo lweepilisi okanye zeepilisi. Nangona kunjalo, unako thenga i-OEA powder ngobuninzi kwimarike ukuba iyafuneka. Le fomu yomgubo ibandakanyiwe kugqityiwe imveliso ngokumisela rhoqo kwi-15% ye-OEA okanye i-50% ye-OEA oleic acid. Isicwangciso seCima OEA sigcinwa phakathi kwe-90% ukuya kwi-95% ngakumbi phakathi kwabathengi baseYurophu naseMelika.

 

BUY I-OLEOYLETHANOLAMIDE (OEA) luthuli NGENANI

Unokubeka i-odolo kwi-Intanethi ngokuthengwa komgubo ngobuninzi okanye ungathenga nakwiivenkile zasekuhlaleni ezidumileyo. Ukugcinwa kulula kakhulu kwimeko ye-OEA powder. Kuya kufuneka uyigcine kubushushu begumbi. Kodwa, akufuneki idibane nokufuma okanye imitha yelanga ethe ngqo. Ke, kuya kufuneka uyigcine ivalwe ngokuqinileyo endaweni epholileyo neyomileyo.

 

UKUQALA

Ukusetyenziswa kwe-OEA inokukunceda ngeendlela ezininzi! Ngesi sizathu, kunconyelwa wonke umntu ngokungabinaziphumo ebezingalindelekanga. Inokude ikhuthaze indlela yokuphila esempilweni kusapho lwakho ikwenze ukhule kwaye ukhanyise imilo, isitayile, kunye nokuzithemba nokuzithemba. Ukugcina nokugcina umzimba wakho ukwimo efanelekileyo, ngakumbi kwabo batyebe kancinci, ayizukukwenza uzive wonwabile kuphela kodwa iya kwenza nabanye ukuba bonwabe kwaye bazingce ngawe.

I-OEA iyakukunceda ukhuphe uxinzelelo lwengqondo ikuncede wenze umbono oqinisekileyo ezingqondweni zabanye. Ke, endaweni yokuziva ukhathazekile kwaye ungonwabanga, lixesha eliphezulu lokuba uthathe isenzo kwaye uqale ukusebenzisa i-OEA kwaye uya kumangaliswa kakhulu kukubona amandla ayo omlingo kwaye uya kuziva uphilile kwaye ucinezelwe.

 

Iingxelo:
  1. I-pi-Sunyer FX, Aronne LJ, Heshmati HM, Devin J, Rosenstock J. Isiphumo se-rimonabant, i-cannabinoid-1 receptor blocker, kwisisindo kunye nemicimbi yengozi ye-cardiometabolic kwizigulana ezikhuluphele okanye ezi-feta: i-RIO-North Melika: ulingo olulawulwa ngendlela engenamkhethe. Ijenali yoMbutho Wezonyango waseMelika. 2006; 295 (7): 761-775.
  2. UGiuseppe Astarita; UBryan C. Rourke; UJohnnie B. Andersen; Jin Fu; UJanet H. Kim; UAlbert F. Bennett; UJames W. Hicks kunye noDaniele Piomelli (2005-12-22). "Ukunyuka kwepostprandial kwe-oleoylethanolamine yokugaya amathumbu amancinci emathunjini aseBurma (Python molurus)". NdinguJ J Physiol Regul eDibeneyo yokuHlanganisa iPhysical. 290 (5): R1407 – R1412.
  3. USarro-Ramirez A, Sanchez-Lopez D, Tejeda-Padron A, Frias C, Zaldivar-Rae J, Murillo-Rodriguez E. Iimolekyuli zeBongo kunye nokutya: imeko ye-oleoylethanolamide. IiNqanaba eziPhakathi zeeNours System kwiiMichiza zeMichiza. Ngo-2013; 13 (1): 88-91.

 

Contents