I-Palmitoylethanolamide (i-PEA): Izibonelelo, uMthamo, Ukusetyenziswa, isongezelelo

I-Palmitoylethanolamide (i-PEA) yintsapho ye-endocannabinoid, iqela lama-acid amide. I-PEA iye yaqinisekiswa ukuba inomsebenzi we-analgesic kunye ne-anti-immune kwaye isetyenziswe kwizifundo ezininzi ezilawulwayo ezigxile kulawulo lweentlungu ezingapheliyo phakathi kwabaguli abadala abaneemeko ezahlukeneyo eziphantsi kwezonyango.

Ithathiwe kumthamo we-500mg-1.5g ngedosi, rhoqo kwiiyure ezimbalwa, i-PEA ibonelela umsebenzisi ngemvakalelo yovuyo, amandla, ukhuthazo, kunye nokuba sempilweni ngokupheleleyo. I-Esp xa idityaniswe ne-mao-b inhibitor, i-hordenine, i-PEA ithatha inqanaba elitsha lokugcoba kunye nolonwabo ngokubanzi.

Akukho ziphumo bezingalindelekanga ziyingxaki. I-PEA inokuthathwa kunye nayo nayiphi na enye into. Ikonyusa isiphumo sokunciphisa iintlungu kwii-analgesics zakudala kunye ne-anti-inflammatories. I-Palmitoylethanolamide inokusetyenziswa ngokudibeneyo nezinye izinto ngaphandle kweziphumo ebezingalindelekanga.

I-Phenethylamine (i-PEA) yindawo ye-organic, i-monoamine alkaloid yendalo, kunye nokulandela umkhondo we-amine, esebenza njengenkqubo ye-nervous system evuselelayo ebantwini.

Xa uthathwa ngomlomo: Ukuthatha i-palmitoylethanolamide KUFANELEKILE UKHUSELEKILE kubantu abadala xa isetyenzisiwe ukuya kwiinyanga ezi-3. Iziphumo ebezingalindelekanga ezinokwenzeka, ezinje ngesisu esibuhlungu, zinqabile kakhulu. Akukho lwazi lwaneleyo lwanokuthenjwa lokwazi ukuba ngaba i-palmitoylethanolamide ikhuselekile ekusebenziseni ixesha elingaphezulu kweenyanga ezi-3.

Kubalulekile ukuba uqaphele ukuba i-melatonin ayilawulwa ngokungqongqo yi-Food and Drug Administration (FDA). Kungenxa yokuba i-melatonin ayithathwa njengechiza. Ke ngoko, inokuthengiswa njengesongezelelo sokutya njengeivithamini kunye neeminerals, ezingagadwanga ngokusondeleyo yi-FDA.

I-PEA yinto yendalo eveliswa ngumzimba; iyasebenza kakhulu kwaye ikhuselekile ukuyisebenzisa njengesongezelelo seentlungu kunye nokudumba.

I-ertyisi zithatha iintsuku ezisi-7 ukuya kwezi-30 ukuze zihlume. I-ertyisi ziya kuhluma ngokukhawuleza ukuba amaqondo obushushu omhlaba angama-65-70 degrees Fahrenheit. Ungayikhawulezisa inkqubo yokuhluma ngokucoca ii-ertyisi iiyure ezingama-24 ukuya kwezingama-48 ngaphambi kokutyala. Ewe kunjalo, zikho ezinye izinto ezichaphazela indlela ii-ertyisi eziza kukhula ngokukhawuleza kwaye zikhule ngayo.

Ezi zongezelelo xa zigqityiwe zincedisa ekwandiseni inqanaba lomsebenzi wobuchopho kunye nokunciphisa uxinzelelo. Iyafumaneka ekhawuntarini, kwaye enye ayifuni mayeza ukuyithenga. I-phenylthylamine ikwasetyenziselwa ukuphucula ukugxila kunye noxinzelelo.

Senze le shedyuli yonyango emva kokunyanga amakhulu ezigulana zentlungu ye-neuropathic. Ngokusekwe kumava ethu eklinikhi, sicinga ukuba ukuqala ngohlobo oluncinci lwe-PEA ubuncinci iintsuku ezili-10 kunokunceda ukufikelela kwinqanaba lokunyanga elifanelekileyo le-PEA.

Uhlobo lwamafutha olufunyenwe ngokwendalo emzimbeni lunokuba sisitshixo sokulala ubusuku obuhle. Abaphandi banethemba lokuba imolekyuli eyaziwa ngokuba yi-PEA- okanye i-palmitoylethanolamide- ayinakunceda kuphela ngokulala kodwa ikwalwa nentlungu kunye nokunciphisa ukudumba.

I-Phenethylamine (i-PEA) yindawo ye-organic, i-monoamine alkaloid yendalo, kunye nokulandela umkhondo we-amine, esebenza njengenkqubo ye-nervous system evuselelayo ebantwini.

Ingathathwa kunye namanye amayeza eentlungu okanye iyodwa, njengoko kucetyiswa yingcali yakho yokhathalelo lwempilo, ukuxhasa ukukhululeka kwentlungu. I-PEA inokunceda ekunciphiseni ukuxhomekeka kumayeza eentlungu aqatha abangela iziphumo ebezingalindelekanga ezingafunekiyo. Esona sibonelelo siphezulu sinokuthatha ukuya kwiinyanga ezi-3 kodwa iziphumo zibonwa rhoqo kwiiveki ezi-4-6.

Iitshokholethi inoxinzelelo oluphezulu kuko nakuphi na ukutya kwe-phenylethylamine, eyikhemikhali eveliswa kwingqondo xa umntu esemathandweni. Kodwa indima ye "chocolate amphetamine" iyaphikiswa. Uninzi ukuba ayizizo zonke i-phenylethylamine ye-chocolate eyenziwe ngemetabolism ngaphambi kokuba ifike kwi-CNS.

Kwizilwanyana ezanyisayo, i-phenethylamine iveliswa kwi-amino acid L-phenylalanine yi-enzyme enuka kamnandi i-L-amino acid decarboxylase ngokusebenzisa i-enzymatic decarboxylation. Ukongeza kubukho bayo kwizilwanyana ezanyisayo, i-phenethylamine ifumaneka kwezinye izinto eziphilayo kunye nokutya, okufana netshokholethi, ngakumbi emva kokuvundiswa kweentsholongwane.

Uphando lubonakalisile ukuba i-PEA inezinto ezichasayo kunye nokuthintela ukunganyangi kwaye ukuyithatha rhoqo kunokunyusa impendulo yendalo yomzimba kwiintlungu ngokunciphisa impendulo yeeseli zenkqubo yeemvakalelo ezibangela iintlungu.

Ithathiwe kumthamo we-500mg-1.5g ngedosi, rhoqo kwiiyure ezimbalwa, i-PEA ibonelela umsebenzisi ngemvakalelo yovuyo, amandla, ukhuthazo, kunye nokuba sempilweni ngokupheleleyo. I-Esp xa idityaniswe ne-mao-b inhibitor, i-hordenine, i-PEA ithatha inqanaba elitsha lokugcoba kunye nolonwabo ngokubanzi.

Kwirhasi, amanqanaba e-hordenine afikelela ubuninzi kwisithuba seentsuku ezi-5 ukuya kwezi-11 zokuhluma, emva koko anciphe kancinci de kusele umkhondo emva kwenyanga enye. Ngapha koko, i-hordenine ibekwe ngokukodwa kwiingcambu.

Nangona iPalmitoylethanolamide inyamezelwe kakuhle ngumzimba, kwimeko yokuba abantu baphawule naziphi na iziphumo ebezingalindelekanga, bacetyiswa ukuba banciphise inani lomthamo ukuya kuma-400 mg ngosuku.

Okubaluleke ngakumbi, icomputer akufuneki ithathwe ngaphezulu kweenyanga ezintathu. Ukusetyenziswa okuzinzileyo kwe-PEA kunokukhokelela kwimicimbi yesisu. Nangona kunjalo, sisiphumo esecaleni esingafane sabonwa. Okubaluleke ngakumbi, i-PEA akufuneki isetyenziswe kulusu kwaye ukhulelwe kwaye abafazi abancancisayo kufuneka bangahlali kude nokusetyenziswa kwayo kuba akukho uphando olwaneleyo okanye ubungqina bokuqinisekisa ukuba iyeza likhuselekile kula maqela. Ngokufanayo, ukuba unesifo kuyo nayiphi na imeko, kusoloko kungcono ukubonana nodokotela ngaphambi kokuthatha isongezelelo esifana nePalmitoylethanolamide.

Impendulo nguCofttek. I-Cofttek sisongezo somvelisi wempahla ekrwada eyaqala ukubakho ngo-2008. Le nkampani iyazingca kakhulu ngeqela labaphumeleleyo abane-R & D elisebenza ubusuku nemini ukuqinisekisa ukuba izinto ezingafunekiyo ezinikwa abaxhasi zikumgangatho ophezulu kakhulu. Okubaluleke ngakumbi, inkampani ityale imali eninzi kwi-biotechnology kunye novavanyo lokuhlalutya. Zonke iimveliso ezithengiswa yinkampani zenziwe ngobuninzi bazo, umzi mveliso wobugcisa obuphezulu ozigwagwisa ngeenkqubo zabathengisi abaqolileyo kunye nezixhobo zobugcisa zamva nje. Kukuzibophelela okwenziwe yinkampani ukuvelisa izinto ezisemgangathweni ezisemgangathweni ezenze ukuba iCofttek ibe ligama elaziwayo kwimarike yempahla eluhlaza. Namhlanje, inabaxhasi kwihlabathi liphela.

I-PEA cream yikrimu equlathe uxinzelelo olulungileyo lwendalo kunye nezinto ezikhuselayo zepalmitoylethanolamide (PEA). I-cream ye-PEA ke inokusetyenziselwa njengesongezelelo esifanelekileyo seziphumo zeephilisi emzimbeni.

I-Palmitoylethanolamide (i-PEA) yimolekyuli enamafutha eveliswa ngesixa esincinci nomzimba, ubukhulu becala ekuphenduleni ukonakala kwethishu okanye ukulimala kwethishu okanye kwezihlunu. I-PEA iveliswa ngokwemvelo ngumzimba womzimba ekuphenduleni intlungu okanye ukuvuvukala. I-Palmitoylethanolamide, ekwabizwa ngokuba yi-PEA yi-lipid eyenzeka ngokwendalo ewela phantsi kweqela lamafutha e-acid. Nangona le ngxube iveliswa ngamajoni omzimba, ikwakhona nakwizilwanyana nakwizityalo kwaye ke, inokufumaneka kwimithombo yangaphandle, enje ngeqanda leqanda, isoya lecithin, ialfalfa, ubisi, amandongomane kunye neembotyi zesoya. I-PEA inezixhobo ezinamandla okunciphisa iintlungu kwaye ke, iyakwazi ukuphembelela imisebenzi emininzi yomzimba emzimbeni.

I-PEA ithathwa ikakhulu kwiinjongo zokulwa nokudumba kunye nokunciphisa iintlungu. Ke, isebenza njani i-PEA kanye ngaphakathi komzimba? Nje ukuba ungene ngaphakathi emzimbeni, i-PEA iyazibophelela kwindawo ekujolise kuyo ecima umsebenzi wokuvutha kweseli emva kwenkqubo yokubopha. Okubaluleke ngakumbi, olunye uphando lubonisa ukuba isiphumo se-analgesic se-PEA sinokubakho kumandla ekhompawundi ukuphazamisa ukusebenza kweeseli ezikhethekileyo zomzimba ezijongene nokudlulisa imiqondiso yeentlungu. Nokuba yeyiphi na indlela ngqo, into inye iqinisekile ukuba i-PEA ibonelela ngesiqabu kwintlungu ye-neuropathic kunye nokuvuvukala.

Kule minyaka imbalwa idlulileyo, iPalmitoylethanolamide (PEA) ikubonile ukunyuka ngesiquphe kokuthandwa kwayo. Nangona iipropathi zonyango lwe-PEA zafunyanwa kwiminyaka yee-1950 kwaye ukusukela ngoko, izazinzulu kunye nabaphandi baye bafunda ngokubanzi eli qela, kule minyaka imbalwa idlulileyo, umdla kwi-PEA ukhule kakhulu. Oku ikakhulu kungenxa yendima yokhuselo kunye neyokuphilisa enokuthi idlalwe ngumzimba ngaphakathi komzimba kunye nokukwazi kwayo ukuphatha iintlobo ezahlukeneyo zokudumba kunye nemicimbi ye-neuropathic.

Nangona kunjalo, umzimba womntu uvelisa i-PEA ngesixa esincinci kwaye amaxesha ngamaxesha kunoko, eli nani alonelanga ukunqanda ukudumba kunye nentlungu kwaye ngenxa yoko, abantu bahlala becetyiswa ukuba bathathe izongezo ze-PEA. Ukunciphisa iintlungu kunye nokudumba yenye yezona zibonelelo zininzi ze-PEA.

Njengento eyenzeka ngokwendalo ye-PEA isongezelelo zihlelwa e-Australia, nakwamanye amazwe amaninzi, njengemveliso yokutya, hayi iziyobisi. I-PEA ibonakalisiwe inezinto ezichasayo, ezinokuthintela ukunganyanzeleki, iipropathi zokulwa i-anticonvulsant kunye ne-neuroprotective kwaye isetyenziswa ngakumbi kunyango lweentlungu ezingapheliyo.

Unyango lwe-Neuropathic Pain Treatment I-Anticonvulsant kunye ne-anti-depressant drug zihlala zililayini lokuqala lonyango. Ezinye izifundo zentlungu ye-neuropathic zibonisa ukusetyenziswa kwezidakamizwa ezingekho-steroidal ezichasayo (i-NSAIDs), ezifana neAleve okanye iMotrin, kunokunciphisa intlungu. Abanye abantu banokufuna i-painkiller eyomeleleyo.

Ukulala ngamadolo akho kuphakanyisiwe kunokunciphisa iimpawu zakho ezibuhlungu ngokunciphisa uxinzelelo kwii-lumbar discs zakho kwindawo yeengcambu zakho. Lala ngomqolo-gcina izithende zakho kunye neempundu unxibelelana nebhedi kwaye ugobe amadolo kancinci usiya eluphahleni.

Iindlela zokuCoca ubuNhlungu beNyango. Gcina phezulu kweswekile. Ukuba unesifo seswekile, gcina iswekile esegazini iphantsi kolawulo. Yicime. Ukuzilolonga kukhupha iintlungu zentlungu ekuthiwa zii-endorphins. Hlanganisa iinyawo zakho. Ukuba iinyawo zichaphazeleka yintlungu yentlungu, lixesha lokuba ugxile kukhathalelo lweenyawo ezilungileyo.

Ayisiyiyo kuphela amanzi afudumeleyo apholileyo, kodwa anokukhuthaza nokujikeleza emzimbeni wakho. UVinik uthi: “Inokukunceda kwangoko. Kodwa ngenxa yokuba isifo seswekile sinokubangela ukulahleka kwemvakalelo, qiniseka ukuba amanzi akashushu kakhulu ngaphambi kokuba ungene.

Ayinakusetyenziswa ngabafazi abakhulelweyo. I-Palmitoylethanolamide inokukunceda ekujonganeni nokuvuvukala kunye nentlungu engapheliyo. Kufuneka kuthathwe kuphela phantsi kolawulo lwezonyango.

I-PEA ibonakalise ukusebenza kweentlungu ezingapheliyo zeentlobo ezininzi ezinxulunyaniswa neemeko ezininzi ezibuhlungu, ngakumbi iintlungu ze-neuropathic (nerve), iintlungu ezivuthayo kunye nentlungu ye-visceral efana ne-endometriosis kunye ne-cystitis yangaphakathi.

I-Palmitoylethanolamide yikhemikhali eyenziwe ngamanqatha. Ifunyanwa ngokwendalo ekutyeni okunje ngezikhupha zamaqanda kunye namandongomane, nasemzimbeni womntu. Isetyenziswa njengeyeza.

I-Epinephrine kufuneka ilawulwe kwiidosi ze-1-mg nge-intravenously / intraosseously (IV / IO) yonke imizuzu ye-3-5 ngexesha lokubanjwa kombane okungafunekiyo (PEA). Iidosi eziphezulu ze-epinephrine ziye zafundwa kwaye azibonisi phuculo ekusindeni okanye kwiziphumo ze-neurologic kwizigulana ezininzi.

Kwimbonakalo ye-PEA etiologies, i-pseudo-PEA ihlala ibangelwa yi-hypovolemia, i-tachydysrhythmias, ukwehla kwesivumelwano sentliziyo, okanye ukuthintela ukujikeleza, okunje nge-pulmonary embolism, tamponade, kunye noxinzelelo lwe-pneumothorax.

I-Hypovolemia kunye ne-hypoxia zezona zizathu zixhaphakileyo ze-PEA. Ziyeyona nto ibuyela umva ngokulula kwaye kufuneka ibe phezulu nakuphi na ukwahluka okuchongiweyo. Ukuba umntu unembuyekezo yokuhamba okuzenzekelayo (ROSC), qhubela phambili ukhathalelo lwasemva kokubanjwa kwentliziyo.

Kule minyaka imbalwa idlulileyo, ukuthandwa kwePalmitoylethanolamide kuye kwangqina ukunyuka okukhulu, ikakhulu ngenxa yokuba abantu baye bazi ngakumbi ukusetyenziswa kwayo okuninzi. Kule mihla, abantu basebenzisa iPalmitoylethanolamide ikakhulu ngenxa yesiphumo sayo sokuthomalalisa iintlungu, kodwa ikwasoloko ichazwa kwizigulo ezinzulu, ezinjengesifo sikaLou Gehrig, isifo seswekile seswekile, isifo sokuqina kwemithambo, i-fibromyalgia, i-carpal tunnel syndrome, i-glaucoma, i-autism, i-eczema, i-endometriosis kunye ezahlukeneyo zokuphazamiseka. Kule mihla, izongezo zePalmitoylethanolamide (PEA) ziyasetyenziswa ngabantu ukukhuthaza ukunciphisa umzimba. Nangona kunjalo, uphando oluthe kratya kufuneka lwenziwe kule ndawo.

① Uphando lwakwangoko lubonisa iziphumo ezithembisayo kunyango lwezifo zikaLou Gehrig

Isifo sikaLou Gehrig okanye i-Amyotrophic lateral sclerosis (ALS) sisifo esisongela ubomi esikhokelela ekonakaleni kweemoto-neuron kwaye ekugqibeleni siqhubeke nokukhubazeka. Uphando lwakwangoko lubonisa ukuba i-palmitoylethanolamide xa ithathwa nge-riluzole, inokunceda ukuphucula le meko. I-PEA yi-endocannabinoid ephucula ukusebenza kwepulmonary kwizigulana ze-ALS.

② Inceda ngeCarpal Tunnel Syndrome

ICarpal Tunnel Syndrome yimeko echaphazela isandla. Abantu abanale meko bahlangabezana nokudinwa kunye nokubamba ngesandla. Imeko ichaphazela isandla sonke, kubandakanya yonke iminwe ngaphandle komnwe omncinci. Isifundo sika-2017 siveze ukuba i-PEA ingasetyenziselwa ngempumelelo ukunyanga ii-syndromes ezinoburharha, kubandakanya iCarpal Tunnel Syndrome. Ke, izongezelelo ze-PEA zinokuthathwa ukuba ziphantsi kolawulo lweentlungu kunye nokungalunganga okubangelwa yi-Carpal Tunnel Syndrome.

③ Iyasebenza ngokuchasene ne-Neuropathy yeswekile kunye ne-Fibromyalgia

Isifo seswekile esibangelwa sisifo seswekile ngumonakalo wemithambo-luvo. Olunye lweempawu eziqhelekileyo zesifo seswekile, kukuqaqanjelwa yimilenze neenyawo. I-Fibromyalgia, kwelinye icala, yimeko echaphazela inkqubo ye-musculoskeletal. Kunye nokukhathala kunye nemicimbi yememori, olona phawu luqhelekileyo lwe-fibromyalgia yintlungu kuyo yonke inkqubo ye-musculoskeletal.

Zombini i-neuropathy yesifo seswekile kunye ne-fibromyalgia ziimeko ezibuhlungu ezingezoqhelekileyo. Ngethamsanqa, iintlungu ezihambelana nazo zombini ezi meko zinokulawulwa ngokusetyenziswa kwe-Palmitoylethanolamide.

④ Inokusetyenziselwa ukunyanga iimpawu zeSifo esiPhindaphindiweyo

I-Multiple Sclerosis yimeko apho amajoni omzimba aqala ukuhlasela i-myelin egubungela i-nerve, yona ikhokelela ekunciphiseni okanye kungabikho nxibelelwano phakathi kwengqondo kunye nomzimba wonke. Esi sifo sinokuphazamisa ngokupheleleyo. Nangona kunjalo, uphando lwangaphambili lubonisa ukuba i-PEA, xa inikwe ngokudibeneyo ne-interferon-beta1a, inokunceda ukunciphisa iimpawu ezinxulumene ne-Multiple Sclerosis.

⑤ Iyasebenza ngokuchasene ne-Glaucoma kunye ne-temporomandibular Disways

I-Glaucoma ngumbandela ochaphazela i-opic nerve kwaye ungunobangela ophambili wobumfama kubantu abaneminyaka engama-60 nangaphezulu. Ukuphazamiseka kwe-TMJ, kwelinye icala, kubangela iintlungu zomhlathi. Uphando lubonisa ukuba i-Palmitoylethanolamide okanye i-PEA inokusetyenziswa ukunyanga iintlungu ezibangelwa zizo zombini ezi meko.

⑥ Ezinye iiNzuzo

Ngaphandle kokusebenzisa okukhankanywe apha ngasentla, i-PEA iyacetyiswa kwakhona kwintlungu ye-nerve kunye ne-analgesic yonyango lwasemva kokuhlinzwa. Ngamanye amaxesha, ikwasetyenziselwa ukunyanga ezinye iimeko, ezifana nentloko, uxinzelelo lwe-eczema, i-endometriosis, i-autism, isifo sezintso kunye neentlungu ze-vulvar. I-PeA ikwabonakalise ukusebenza ngokuchaseneyo nokufumana isisindo. Nangona kunjalo, uphando olungaphezulu luyafuneka kwezi ndawo.

Kule minyaka idlulileyo, izifundo ezahlukeneyo zisebenzise idosi eyahlukeneyo kwaye ngenxa yoko, akukho dosi inokuthathwa ifezekile. Nangona kunjalo, abantu bayacetyiswa ukuba bagcine i-Palmitoylethanolamide (PEA) yokuthatha idosi ngaphantsi kwe-300-1,200 mg ngosuku. Abo bathatha izongezo zePalmitoylethanolamide bayacetyiswa ukuba bathathe i-350-400 mg kathathu ngemini kwaye ubude beedosi abufanele ukuba ngaphezulu kweenyanga ezi-2 zizonke.