β-I-Nicotinamide Mononucleotide (1094-61-7) Umvelisi-eCofttek

I-β-Nicotinamide Mononucleotide (1094-61-7)

Aprili 7, 2020

I-Nicotinamide Mononucleotide, ekwabizwa ngokuba yi ("NMN" kunye ne "β-NMN") yi-nucleotide ethathwe kwi-ribose kunye ne-nicotinamide NADH).

 


Isimo: KwiMveliso yoLuntu
Iyunithi: 1kg / ingxowa, 25kg / Igubu

I-β-Nicotinamide Mononucleotide (1094-61-7) yokuzonwabisa

 

I-Nic-Nicotinamide Mononucleotide (NMN) Suqobo

igama: I-Nic-Nicotinamide Mononucleotide (NMN)
CAS: 1094-61-7
Ukungcola 98%
Ifomula yeMolekyuli: C11H15N2O8P
Ubunzima Ezinto: 334.2208 g / mol
Melt Point: > 96 ° C
Igama leKhemikhali: ((2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate
Iintetho: I-Nikotinamide Mononucleotide; NMN; I-β-NMN; I-Nic-Nicotinamide mononucleotide
InChI Key: I-DAYLJWODMCOQEW-TURQNECASA-N
Ubomi obulicla: N / A
Umzimba: I-soluble kwi-DMSO, Methanol, Amanzi
Umbandela woGcino: 0 - 4 C ixesha elifutshane (iintsuku ukuya kwiiveki), okanye -20 C ixesha elide (iinyanga)
isicelo: I-Nicotinamide mononucleotide (NMN) sisiphumo se-B-Vitamin niacin esiphucula kakhulu impilo kunye nokuphila ixesha elide ngokukhonza njengommisi we-NAD +, ikhompawundi edlala indima ebalulekileyo kwimveliso yamandla, kwimetabolism, nasekubonakalweni komzimba emzimbeni.
Kubonakala: Powder

 

Yintoni i-β-Nicotinamide Mononucleotide (NMN) CAS 1094-61-7?

I-Nicotinamide Mononucleotide, ekwabizwa ngokuba yi ("NMN" kunye ne "β-NMN") yi-nucleotide ethathwe kwi-ribose kunye ne-nicotinamide NADH). Ngenxa yokuba i-NADH yi-cofactor yeenkqubo ngaphakathi kwe-mitochondria, ye-sirtuins, kunye ne-PARP, i-NMN ifundwe kwiimodeli zezilwanyana njenge-arhente ye-neuroprotective kunye ne-anti-aging agent.

 

I-β-Nicotinamide Mononucleotide (NMN) CAS 1094-61-7 izibonelelo

Uphando oluchasene nokwaluphala lubonakalisile ukuba ulongezelelo kunye ne-NMN, isitshixo esiphambili se-NAD +, siyasebenza ekunciphiseni ukwehla okunxulumene nobudala be-metabolic kunye nokucothisa ukuqhubela phambili kwesininzi sezifo ezinxulumene nobudala. I-NMN ineziphumo ezizizo kwimveliso yamandla kwinqanaba leeselula, iphucula unyamezelo kwiswekile, inciphisa ukuvuvukala, inceda ukugcina inkqubo yokujikeleza, ilungisa iDNA, kwaye ineziphumo ezihle kulondolozo lomsebenzi wengqondo. I-NMN ikwabonakalise ukuba nakho njenge-arhente yonyango ngokuchasene nokuphazamiseka kwe-neurodegenerative yesiqhelo yobudala. Ukongezwa kunye ne-NMN kunokuba luncedo ekugcineni unyamezelo kunye nokuhamba. Ukulondolozwa kwemisebenzi yezi nkqubo zahlukeneyo emzimbeni kukhuthaza impilo kunye nobomi obude kwaye kuphucula kakhulu umgangatho wobomi njengoko ukwaluphala kuqhubeka.

 

I-β-Nicotinamide Mononucleotide (NMN) CAS 1094-61-7 Indlela yokusebenza?

I-Nic-Nicotinamide Mononucleotide (NMN) iphakathi kwe-NAD + biosynthesis eveliswe kwi-nicotinamide nge-nicotinamide phosphoribosyltransferase (NAMPT) ekwabizwa ngokuba yi-NMN okanye i-nicotinamide ribotide. Kuphononongo lwakutsha nje lwezicelo ze-NMN kuthintelo kunye nokuchongwa kwezifo ezixhomekeke kubudala ezinje ngeswekile, isifo se-neurodegenerative, isifo sentliziyo njlnjl.

 

I-β-Nicotinamide Mononucleotide (NMN) CAS 1094-61-7 isicelo

I-β-Nicotinamide Mononucleotide (NMN) ineziphumo ezizizo kwimetabolism emzimbeni wonke, kubandakanya iziphumo ezichanekileyo kwimisipha yamathambo, ukusebenza kwesibindi, ukuqina kwithambo, ukusebenza kwamehlo, ukuziva nge-insulin, ukusebenza komzimba, amanqanaba omzimba kunye nomsebenzi.

 

I-Nic-Nicotinamide Mononucleotide (NMN) powder kwintengiso(Ungayithenga phi β-Nicotinamide Mononucleotide (NMN) umgubo ngobuninzi)

Inkampani yethu iyonwabela ubudlelwane bexesha elide kunye nabaxumi bethu kuba sigxile kwinkonzo yabathengi kunye nokubonelela ngeemveliso ezintle. Ukuba unomdla kwimveliso yethu, siyaguquguquka ngendlela eqhelekileyo yokwenza ii-odolo ukuze zilungele iimfuno zakho ezithile kunye nexesha lethu elikhawulezayo lokufumana iiodolo uqinisekisa ukuba uyayiva imveliso yethu kwangexesha. Sijolise kwakhona kwiinkonzo ezongezwe ngexabiso. Sifumaneka kwimibuzo yenkonzo kunye nolwazi lokuxhasa ishishini lakho.

Siyi-β-Nicotinamide Mononucleotide (NMN) umthengisi wempuphu iminyaka eliqela, sinikezela iimveliso ngexabiso lokukhuphisana, kwaye imveliso yethu ikumgangatho ophezulu kwaye iyavavanywa ngokungqongqo, ezimeleyo ukuze kuqinisekiswe ukuba ikhuselekile emhlabeni jikelele.

 

Ucaphulo

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  • Lukacs M, Gilley J, Zhu Y, Orsomando G, Angeletti C, Liu J, Yang X, Park J, Hopkin RJ, Coleman MP, Zhai RG, Stottmann RW. Iinguqu ezi-biallelic ezintathu zokulahleka-kokutshintsha komsebenzi kwi-nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2) kwizibeleko ezibini ezilandelelanayo zokulandelelana kwe-fetus akinesia. I-Neurol. I-2019 Meyi 25: 112961. doi: 10.1016 / j.expneurol.2019.112961.PubMed PMID: 31136762.
  • Grozio A, Mills KF, Yoshino J, Bruzzone S, Sociali G, Tokizane K, Lei HC, Cunningham R, Sasaki Y, Migaud ME, Imai SI. I-Slc12a8 yinto yokuhamba ye-nicotinamide mononucleotide transporter. Nat Metab. Ngo-2019 Jan; 1 (1): 47-57. doi: 10.1038 / s42255-018-0009-4. Epub 2019 Jan 7. I-PubMed PMID: 31131364; I-PubMed Central PMCID: PMC6530925.