Eyona J-147 (1146963-51-0) yomvelisi womgubo-eCofttek

I-J-147 (1146963-51-0)

Ngamana 7, 2021

ICofttek yeyona mveliso ingcono ye-J-147 yomgubo eTshayina. Umzi-mveliso wethu unenkqubo epheleleyo yolawulo lwemveliso (i-ISO9001 kunye ne-ISO14001), kunye nemveliso yenyanga ye-120kg.

 


Isimo: KwiMveliso yoLuntu
Iyunithi: 1kg / ingxowa, 25kg / Igubu

I-J-147 (1146963-51-0) Suqobo

igama: J-147
CAS: 1146963-51-0
Ukungcola 98%
Ifomula yeMolekyuli: C18H17F3N2O2
Ubunzima Ezinto: 350.341 g / mol
Melt Point: 177-178 ° C
Igama leKhemikhali: 2,2,2-Trifluoroacetic acid 1-(2,4-Dimethylphenyl)-2-[(3-methoxyphenyl)methylene]hydrazide
Iintetho: N- (2,4-Dimethylphenyl) -2,2,2-trifluoro-N '- [(E) - (3-methoxyphenyl) methylene] acetohydrazide
InChI Key: HYMZAYGFKNNHDN-SSDVNMTOSA-N
Ubomi obulicla: I-1.5 hrs kwi-plasma kunye ne-2.5 hrs kwingqondo
Umzimba: Iinyibilika kwi-100 mM kwi-DMSO ukuya kwi-100 mM kwi-ethano
Umbandela woGcino: 0 - 4 C ixesha elifutshane (iintsuku ukuya kwiiveki), okanye -20 C ixesha elide (iinyanga)
isicelo: I-J-147 powder yipilisi entsha yokulinga ephuhliswayo njengonyango olunokwenzeka kwisifo se-Alzheimer's.
Kubonakala: Imhlophe yomgubo ococekileyo omhlophe

 

I-J-147 (1146963-51-0) Spectrum yeNMR

I-J-147 (1146963-51-0)

Ukuba ufuna i-COA, i-MSDS, i-HNMR kwibhetshi nganye yemveliso kunye nolunye ulwazi, nceda unxibelelane nathi umalwuli wezentengiso.

 

Yintoni iJ-147 (1146963-51-0)?

I-J-147 powder sisiyobisi esitsha solingo esenziwa njengonyango olunokwenzeka kwisifo se-Alzheimer's. Ukuza kuthi ga ngoku, iimvavanyo ezenziwe kwiimpuku zibonisa isithembiso esikhulu. I-J147 ixele iziphumo ekubuyiselweni kweziphumo zesifo sengqondo esixhalabisayo kunye ne-Alzheimer's kwiimodeli zemouse. I-J147 ithatha indlela eyahlukileyo ngokuthelekiswa nezinye iziyobisi zeNootropics kunye neAlzheimer's. I-J147 izama ukususa iidipozithi zobumba kwingqondo. Bekwaphawula ukuba i-J147 inamandla okujongana neminye imiba yokuguga yemvelo, hayi nje ilahleko yememori. Iyeza linganceda ukukhusela ukuvuza kwegazi kwii-microvessels, njengoko kubonisiwe kuvavanyo lweempuku kude kube ngoku. Iyeza laqala ukwenziwa ngonyaka ka-2011. Ukusukela oko, iimvavanyo zenziwe kwiimpuku kodwa asikaziboni naluphi na uvavanyo olubanzi olusekwe eluntwini. Nangona kunjalo, olunye uphando olupapashwe kulo nyaka uphelileyo luveza umfanekiso olungileyo wokuba i-J147 isebenza njani ngaphakathi kwengqondo yomntu. Ngokwephepha, eli chiza libophelela iprotheyini mitochondria. Iiseli zeMitochondria zihlala zinoxanduva lokuvelisa amandla. Intshukumo ye-J147 kubo iphucula ukwenziwa kweeseli. Olu ncedo lubaluleke kakhulu ekubuyiseni ilahleko yememori nasekuphuculeni impilo yengqondo iphela.

 

J-147 (1146963-51-0) izibonelelo

UMeyi unokubuyisela umva ukuphazamiseka kweBongo

I-J147 ibonise isithembiso esininzi sokubuyisela umva impembelelo yokuphazamiseka kwengqondo kwi-neurodegenerative yengqondo njenge-Alzheimer's kunye nabanye. Kuvavanyo olwenziwe kwiimodeli zegundwane ukuza kuthi ga ngoku, ichiza libonise iimpembelelo ezintle ekujonganeni nale meko.

I-J147 isebenza ngokunceda iiseli ekubuyiselweni kwengqondo kwakhona, zizenze zincinci kwaye zisebenze ngakumbi kuneeseli ezindala. Nangona kunjalo, kubalulekile ukuba uqaphele ukuba akukho zilingo zomntu ezenziwe kwi-J147. Ngethemba, oko kuyakwenzeka kungekudala kodwa ichiza lisafumaneka ngokuthengiswa njengomgubo kubathengisi abakhethekileyo abakwi-Intanethi.

 

Ukuphucula isenzo seMitochondria kunye nokuPhila ixesha elide

I-J147 isebenza ngokubopha kwi-mitochondria, iiseli ezinoxanduva lokuvelisa amandla kwimizimba yethu. Isenzo se-J147 sinceda ukukhusela uxinzelelo lwe-oxidative kwiiseli ze-mitochondria, ezikhokelela ekusebenzeni ngcono kweseli kunye nokuphila ixesha elide.

I-J147 ikwanceda ukunciphisa i-metabolites eziyityhefu ezinokubangela ukugcwala kweseli, inkqubo leyo iiseli ezifa ngayo xa zidlula kakhulu. Oku kuvumela iiseli zakho ukuba zihlale zintsha kwaye zisempilweni ixesha elide. Ngapha koko, ezinye iindlela ezenziweyo kwizifundo zezilwanyana zabonisa ukuba ulawulo lwe-J147 kwiimpukane zeziqhamo luyolula ixesha labo lobomi nge-9.5 ukuya kwi-12.8%.

 

Iphucula Inkumbulo

I-J147 ikwabonakalise isithembiso esikhulu phakathi kweemodeli zeemouse zokuphucula imemori. Eli chiza lide lanceda ukuguqula imeko ebukhali yokuqonda kwengqondo kwizifundo zovavanyo ezindala ngexesha lophando.

Abaphandi bakholelwa ukuba ezi ziphumo zinokuthi ziphindaphindwe kwizifundo zabantu. Kukho ubungqina obucebisa ukuba i-J147 inokuphononongwa njengonyango olunokwenzeka kwimemori yendawo.

 

Ikhusela i-Neurons kwaye inceda ukukhula kweBongo

I-J147 ikwanepropathi ye-neuroprotective ethintela isenzo se-oxidative ngaphakathi kweeseli. Oku kunceda ukukhusela i-neurons kumonakalo onokwenzeka. I-J147 inokuba sisizathu sokukhula kwengqondo. I-J147 inokuphucula imeko ye-synaptic yengqondo kwingqondo, ekhokelela ekukhuleni.

 

I-J-147 (1146963-51-0) setyenziso?

Ukunyusa ukuqonda

Isongezelelo seJ-147 siphucula indawo kunye nenkumbulo yexesha elide. Iyeza libuyisela umva kwiziphene zokuqonda phakathi kwabantu abadala abajamelana nokuphazamiseka kwengqondo. I-J-147 iyathengiswa iyafumaneka njengethamo elingaphezulu kwekhawuntareni kwaye isizukulwana esincinci siyithatha ukukhulisa amandla okufunda. Ukuthatha iziyobisi ezichasene nokuguga kwe-J-147 kuya kukhulisa inkumbulo, umbono kunye nokucaca kwengqondo.

 

Ulawulo lwezifo ze-Alzheimer

I-J-147 izibonelelo zezigulana ezine-Alzheimer ngokucothisa ukuqhubela phambili kwale meko. Umzekelo, ukuthatha isongezo kunciphisa amanqanaba e-beta-amyloid enyibilikayo (Aβ), ekhokelela kukungasebenzi kakuhle kwengqondo. Ngaphandle koko, i-J-147 curcumin imodareyitha ukubonakaliswa kwe-neurotrophin ukuqinisekisa ukusinda kwe-neuronal, yiyo loo nto, ukubunjwa kwememori kunye nokuqonda.

Izigulana ezine-AD zinezinto ezimbalwa ezingaphantsi kwe-neurotrophic. Nangona kunjalo, ukuthatha i-J-147 Alzheimer's supplement kuyonyusa zombini i-NGF kunye ne-BDNF. Ezi neurotransmitters zinceda ukuyilwa kwememori, ukufunda, kunye nemisebenzi yokuqonda.

 

I-J-147 (1146963-51-0) umyinge

Izifundo ezahlukeneyo zisebenzise iidosi ezahlukeneyo kwiimpuku, kodwa esinye sezifundo ezijongwa ngcono sanika iimpuku 10 mg / kg yesisindo somzimba ngosuku. Olunye uphononongo lusebenzise iidosi ze-1, 3 okanye 9 mg / kg, kwaye zafumana iziphumo ezixhomekeke kwidosi, kunye needosi eziphezulu ezisebenza ngcono.

Nangona kunjalo, ukuguqulela oku kumthamo womntu kufuna uhlengahlengiso kumphezulu womzimba. Ngokwendlela yokuguqula esetyenziswa ngokuxhaphakileyo, idosi elingana nomntu kufuneka ilingane idosi yemouse eyahlulwe ngo-12.3 – okanye .81 mg nge-kg yomzimba ngosuku.

Yiyo .36 mg ye-J147 ngeepawundi yomzimba ngosuku. Oku kungangama-36 mg ngosuku kumntu olikhulu leepawundi, i-54 mg yomntu onepawundi ezili-150, okanye ama-72 mg kumntu ophawulwe ngama-200.

Nangona kunjalo, olunye uphononongo lufumene iziphumo ezilungileyo ezivela nakwidosi ezisezantsi, kwaye unikwe ukuba i-J147 ijolise kwingqondo, akucaci gca ukuba idosi inokulinganisa ngokugqibeleleyo kubungakanani bomzimba.

Kananjalo, la manani kufuneka ajongwe njengemida ephezulu, kwaye kukho izizathu zokukholelwa ukuba i-10 ukuya kwi-20 mg ngosuku kufuneka yanele ukuba nefuthe elithile.

 

J-147 powder kwintengiso(Apho unokuthenga khona i-J-147 powder ngobuninzi)

Inkampani yethu iyonwabela ubudlelwane bexesha elide kunye nabaxumi bethu kuba sigxile kwinkonzo yabathengi kunye nokubonelela ngeemveliso ezintle. Ukuba unomdla kwimveliso yethu, siyaguquguquka ngendlela eqhelekileyo yokwenza ii-odolo ukuze zilungele iimfuno zakho ezithile kunye nexesha lethu elikhawulezayo lokufumana iiodolo uqinisekisa ukuba uyayiva imveliso yethu kwangexesha. Sijolise kwakhona kwiinkonzo ezongezwe ngexabiso. Sifumaneka kwimibuzo yenkonzo kunye nolwazi lokuxhasa ishishini lakho.

Singumthengisi olicwecwe we-J-147 iminyaka eliqela, sinikezela ngeemveliso ngamaxabiso aphantsi, kwaye imveliso yethu ikumgangatho ophezulu kwaye iyavavanywa ngokungqongqo, nokuzimela ukuqinisekisa ukuba kukhuselekile ukusetyenziswa kwihlabathi liphela.

 

Ucaphulo

[1] "Uvavanyo olujolise kwiziyobisi lwesifo i-Alzheimer lubonisa iziphumo ezichasene nokwaluphala". IZiko leSalk. 12 Novemba 2015. Ibuyiswe ngo-Novemba 13, 2015.

[2] UBrian L. Wang (13 Novemba 2015). "Uvavanyo olujolise kwiziyobisi lwe-Alzheimer lubonisa iziphumo ezichasene nokwaluphala kwiimvavanyo zezilwanyana". izgange.biz. Ifunyenwe ngoNovemba 16, 2015.

[3] USolomon B (Okthobha 2008). "I-Filamentous bacteriophage njengesixhobo sonyango esitsha kunyango lwesifo se-Alzheimer". Ijenali yeSifo se-Alzheimer. 15 (2): 193–8. IINKCUKACHA: