I-NR powder (23111-00-4)

Aprili 7, 2020

ICofttek yeyona ilungileyo iNicotinamide Riboside Chloride powder umenzi eTshayina. Umzi-mveliso wethu unenkqubo epheleleyo yolawulo lwemveliso (i-ISO9001 kunye ne-ISO14001), kunye nemveliso yenyanga eyi-2100kg.

 


Isimo: KwiMveliso yoLuntu
Iyunithi: 1kg / ingxowa, 25kg / Igubu

 

I-NR powder (23111-00-4) ividiyo

 

INicotinamide Riboside Chloride (NR) Suqobo

igama: Nicotinamide Riboside chloride (NR)
CAS: 23111-00-4
Ukungcola 98%
Ifomula yeMolekyuli: C11H15ClN2O5
Ubunzima Ezinto: 290.7 g / mol
Melt Point: 115-125 ℃
Igama leKhemikhali: 3-carbamoyl-1-((3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium chloride
Iintetho: I-Nikotinamide riboside; I-SRT647; I-SRT-647; I-SRT 647; I-Nicotinamide Riboside Triflate, umxube we-α / β
InChI Key: IYABIFCKURFRPPO-FSDYPCQHSA-N
Ubomi obulicla: iiyure 2.7
Umzimba: I-soluble kwi-DMSO, Methanol, Amanzi
Umbandela woGcino: 0 - 4 C ixesha elifutshane (iintsuku ukuya kwiiveki), okanye -20 C ixesha elide (iinyanga)
isicelo: I-Nicotinamide riboside kuthiwa yimo entsha ye-pyridine-nucleoside yevithamini B₃ esebenza njengomanduleli weNicotinamide adenine dinucleotide okanye NAD +.
Kubonakala: Inikezelwe mhlophe kwiPalela yoMgubo

 

INicotinamide Riboside Chloride

Umzimba womntu sisakhiwo esintsonkothileyo esenziwe ziiseli, izicwili kunye neenkqubo zomzimba. Ukusebenza ngokufanelekileyo kweeseli kunye nezicubu emzimbeni kulawulwa kwaye kuncediswa ziikhemikhali ezahlukeneyo, ii-enzymes, kunye nezondlo. Ezinye zezi zinto zinokuzenzela, kwaye ezinye kufuneka zisetyenziswe. Ngenxa yoko, ezi zinongo zikwimo yokutya kunye nezongezo. Elinye lala macandelo anokunceda ukuphilisa kunye nokulawula umzimba ubizwa ngokuba yi-nicotinamide riboside chloride (NR). Kuyanceda ukwandisa inani le-nicotinamide adenine dinucleotide (NAD +) emzimbeni.

 

Wenza ntoni uNicotinamide Riboside chloride?

I-Nicotinamide Riboside Chloride, ekwabizwa ngokuba yi-NR, yi-pyridine nucleoside ye-vitamin B3. Isebenza njengomanduleli wenicotinamide adenine dinucleotide (NAD +). Iyafumaneka njengombala o-off-white to powder yellow color colored. Yenye yezona zinto zifundwe kakuhle ze-NAD + njengoko inezibonelelo ezininzi zempilo. 

I-NAD + inxulunyaniswa yenye yezona zinto ziphambili ezisebenza ngeendlela ezahlukeneyo ze-homeostasis emzimbeni. Inokukunceda ukugcina umzimba usempilweni, ukwandisa ubude beeseli, ukunceda ukwenza imisebenzi eyahlukeneyo yokutya kunye nokunceda ekunyangeni ii-pathophysiologies ezahlukeneyo emzimbeni. 

I-NR powder ibonise ukusebenza kakuhle njengonyango olukhulayo kwizifo ezahlukeneyo. Kwiidosi eziphezulu, i-NR inokunyanga iimeko ezinjengezifo zentliziyo, izifo ezingenayo i-neurodegenerative, izifo ze-musculoskeletal, kunye nokuphazamiseka komzimba. I-NR ikwabonakalisiwe ukuba ilibazise ukuguga kweeseli kunye nokwandisa ubomi babo. Itholakala kwimveliso yokutya njengeentlanzi, iinkukhu, amaqanda, ubisi kunye ne-cereal. 

 

Wenza ntoni uNicotinamide Riboside chloride?

Ukuqonda okwenziwa yi-nicotinamide riboside chloride, kufuneka siqale siqonde i-nicotinamide adenine dinucleotide okanye i-NAD +. 

I-NAD + yi-coenzyme ebalulekileyo emzimbeni womntu. Isebenza ekwenzeni iindlela ezahlukeneyo zemetabolic. Ubukho bayo emzimbeni buyimfuneko ekunyangeni iintlobo ezininzi zezifo. Kuyanceda ukuvelisa amandla engqondo, iiseli zomzimba, kunye nezihlunu.

Isixa se-NAD + esinokufumaneka kwimithombo yokutya sincinci kakhulu. Oku akwanelanga ukuba kusetyenziswe iiseli ezininzi zomzimba. Ukuyivelisa, umzimba uhamba ngeendlela ezahlukeneyo. Zintathu iindlela eziphambili apho i-NAD + inokwenziwa khona. Umendo we-De novo synthesis, indlela ye-Preiss Handler, kunye nendlela ye-Salvage.  

Indlela ye-Salvage yeyona nkqubo ixhaphakileyo eyenziwa ngayo yi-NAD + emzimbeni. Kule ndlela, i-NAD + iphantsi kokuphendula kwakhona. Kubandakanya ukuncitshiswa ngokulingana kwee-elektroni ezimbini, ezijika zibe yifom ebizwa ngokuba yi-nicotinamide adenine dinucleotide (NADH). Kuba ukongezwa kokutya akonelanga kwimfuno yomzimba ye-NAD +, indlela yokuhlangula isebenzisa iphinde isebenzise i-NAD + esele ikho kunye neendlela zayo ezahlukeneyo. 

 Enye yezona zenzo ziphambili ezenziwa yi-NAD + kukusebenzisa ii-sirtuins, iqela lee-enzymes ezisi-7, uSirt1 ukuya kuSirt7. Ezi enzymes zinomsebenzi wokulawula ukuguga kunye nokuhlala ixesha elide kweeseli. I-Sirtuins isebenza kwiinkqubo ezininzi ze-metabolic, njengokukhutshwa kwe-insulin, ukuhlanganiswa kwe-lipids, kunye nokuphendula koxinzelelo. Inokulawula nexesha lokuphila. I-Sirtuins iyasebenza xa amanqanaba e-NAD + enyuka. 

I-NAD + ikwasisiqwengana seqela leeproteni ezibizwa ngokuba yi-poly ADP-ribose polymerase (PARP). Inoxanduva lokulungiswa kwe-DNA kunye nozinzo kwii-genomes kwaye inokuba noxanduva lokuphila ixesha elide. 

Amanqanaba e-NAD + ancipha ngobudala kunye nezifo. Ezinye zezizathu zokwehla kwayo kukudumba okungapheliyo, ukonyusa ukusebenza kwenkqubo yomzimba yokuzikhusela, kunye nokwehla komsebenzi we-nicotinamide phosphoribosyltransferase (NAMPT), ekhokelela ekunciphiseni kwemveliso. Njengokuba umzimba womntu uguga, inqanaba lomonakalo le-DNA liyonyuka ngamathuba amancinci okulungiswa, kubangele ukuguga kunye nomhlaza. 

Kukho iindlela ezimbalwa zokunyusa amanqanaba emanqanaba eNAD + emzimbeni. Batya kancinci kwaye balawula inani leekhalori, ukuzila ukutya, kunye nokuzilolonga. Le misebenzi inokunceda ukugcina umzimba usempilweni kwaye usebenza.

Ezinye iindlela zokwandisa i-NAD + zibandakanya ukusebenzisa i-tryptophan kunye ne-niacin kunye nokuthatha i-NAD + yokunyusa njenge-nicotinamide riboside chloride kunye ne-nicotinamide mononucleotide. 

INicotinamide riboside chloride sisandulela esinokwandisa amanqanaba eselula eNAD +. Ikwangumthombo weVitamin B3. Yimveliso esebenza kwindlela yokuhlangula kwimveliso yeNAD +. Iguqula ibe yi-nicotinamide mononucleotide (NMN) ngoncedo lwe-enzyme NR kinase Nrk1. Emva koko iguquka ibe yi-NAD +. 

Emva kokubonelela nge-NR, amanqanaba e-NAD + ayonyuka emzimbeni, ethi ihanjiswe kwiindawo ezahlukeneyo. Ayikwazi ukuwela isithintelo segazi-lobuchopho, kodwa iyajika ibe yi-nicotinamide ethi ihanjiswe iye kwingqondo nakwezinye izicwili apho yenza i-NAD +. 

Uninzi lolwazi malunga nokusebenza kweNicotinamide Riboside chloride luvela kuphando lwezilwanyana. Uphando olusekwe ebantwini lusikelwe umda kwaye luyafuneka kakhulu.

 

Izibonelelo zeNicotinamide Riboside Chloride

Zininzi izibonelelo zokusebenzisa iNicotinamide Riboside Chloride. Bazi: 

 

Iziphumo kwizifo zeNeuromuscular

Amandla kaNicotinamide riboside chloride wokunyusa i-NAD + anokuphucula imisebenzi ye-mitochondria. Oku kunokunceda ekunyangeni i-myopathies ye-mitochondrial [1]. I-NR powder iye yaboniswa ukuba iyasebenza ekuphuculeni imisebenzi ye-muscular dystrophies.

 

Iziphumo kwizifo zentliziyo

Naziphi na iingxaki nge-NAD + metabolism zinokubangela iingxaki ngentliziyo kunye nemithambo yegazi. Inokubangela iimeko ezinje ngokusilela kwentliziyo, uxinzelelo kumthwalo ongaphezulu, infarction ye-myocardial, njl. (I-NADH) yesiqhelo kwaye ayeke ukulungiswa okungalunganga kwezicubu zentliziyo [2]. Inokuguqula iziphumo zokungaphumeleli kwentliziyo. 

 

Iziphumo kwizifo ze-neurodegenerative

Izifo ze-Neurodegenerative zihlala zenzeka ngokwaluphala. Banxulunyaniswa noxinzelelo lwe-oxidative olunokubangela ukonakala kwi-DNA. Ngokwesiqhelo, kuya kubakho iintshukumo ezingaqhelekanga zemitochondria, kulandela izinto ezithile emva koko iiseli ezingazukusebenza kakuhle. I-NAD + iyancipha kwimali njengobudala bomzimba, ekhokelela ekusebenzeni ngokungalunganga kwemitochondria. Oku kunokubangela izifo ezahlukeneyo ze-neurodeergenerative. Inokwandisa amathuba esi sifo sika-Alzheimer. 

I-Nicotinamide Riboside chloride inyusa inani le-NAD + emzimbeni, inciphisa uxinzelelo lwe-oxidative, kwaye inokulungisa i-DNA eyonakeleyo. Kuyanceda nasekunyangeni isifo se-Alzheimer kwiimpuku [3]. Inokunciphisa nokudumba kwengqondo, inceda ekuphuculeni ukuqonda kunye nenkumbulo [4]. Inokukwenza oku ngokunciphisa isixa seprotein eyandulelayo ye-amyloid-β kunye nokuthintela i-amyloidogenesis. 

I-NR powder inokumisa nokuhla kwe-axon kwiindlela ezingapheliyo zezifo ezingenayo i-neurodegenerative ngokutshintsha i-metabolism ye-NR kwi-axon [5]. Ukonakala kwe-ganglion neurons ejikelezayo engalondolozi iiseli zeenwele ezinokubakho kunokwenzeka emva kokuvezwa yingxolo egqithisileyo. I-NR ibonakalisile ukuba iyasebenza ekuthinteleni ukulahleka kwendlebe okubangelwa yingxolo. Ikwenza oku ngokusebenza kwi-sirtuin okanye indlela exhomekeke kwi-SIRT3 ecutha ukonakala kwe-neurite [6].  

 

Iziphumo kubantu abaneswekile

I-Nicotinamide i-ribonucleoside chloride ibonakalise ukuba iyasebenza ekunciphiseni iimpawu zokuphazamiseka emzimbeni njenge-Type II diabetes [7]. Kubonakalisiwe ukuphucula ukunyamezelana kwiswekile, ukunciphisa ubunzima kunye nokunyanga ukonakala kwesibindi kwiimpuku. Ke inokusebenza ekunyangeni abantu ngokunjalo. 

 

Iziphumo kwimpilo yesibindi

Iimeko zesibindi ezinje ngesifo esinamafutha esingatyisi sinxilise ukubonakaliswa kwe-NAD +. Ke, ukongeza nge-NR powder kunokunceda ekubuyiseni okungcono kwezi meko [8]. 

 

Iziphumo zokuguga 

I-NAD + ifunyenwe ukunciphisa ukuguga kweeseli kunye nokuzivuselela. Kufunyenwe ukuba kuphuculwe imisebenzi ye-stem cell ekwanceda ukunciphisa ukuguga [9]. 

 

Uncedo lweNicotinamide Riboside Chloride ngaphezulu kwezinye i-NAD + Precursors

I-NR ine-bioavailability engcono kwaye ikhuselekile ekusebenziseni ngokuthelekiswa nezinye izandulela. Kubonakalisiwe ukunyusa amanqanaba e-NAD + ngakumbi ekutyeni ngomlomo kwiimpuku kwaye ikwabonelela ngakumbi nge-NAD + kwiimisipha xa kuthelekiswa nezinye izinto ezingaphambili. Inokulawula kwakhona amanqanaba epidid yegazi ngcono kwaye inyuse inqanaba le-NAD + entliziyweni [10]. 

 

Iziphumo ebezingalindelekanga zeNicotinamide Riboside Chloride

Ukungeniswa ngomlomo kwe-nicotinamide riboside chloride kwiidosi ezisezantsi kukhuselekile. Inokubandakanya ezinye iziphumo ebezingalindelekanga ezinje

  • I sizathu
  • Ukuqhawula 
  • Edema
  • Ukutshiza
  • Ukukhathala
  • Intloko
  • Uhudo
  • Isisu esimoshakele
  • Ukunyanzelisa
  • Ukuvutha

 

Ungayithenga njani iNicotinamide Riboside Chloride?

Ukuba ufuna ukuthenga umgubo we-NR, kungcono ukuba unxibelelane ngqo nomzi-mveliso womvelisi weNicotinamide Riboside Chloride. Iqinisekisa ukuba ezona zinto zisetyenzisiweyo zisetyenziselwa imveliso, phantsi kweliso elibukhali leengcali kwicandelo elinxulumene noko. Ezi mveliso zenziwe ngokulandela izikhokelo zokhuselo ezingqongqo eziqinisekisa ukuba imveliso ikumgangatho ophezulu, inamandla amakhulu, kwaye ipakishwe ngokufanelekileyo. Ngokwemfuno yomsebenzisi, iiodolo zingenziwa ngokwezifiso ukuze zilungele incasa yazo ethile. 

Nje ukuba imveliso yenziwe, kufuneka igcinwe kubushushu obubandayo be-0 ukuya kwi-4C kwixesha elifutshane kunye -20C ixesha elide. Kukuthintela ukuba konakalise okanye kuphendulwe nezinye iikhemikhali kwindalo esingqongileyo.

 

Ucaphulo

  • I-Chi Y, iSauve AA. I-Nicotinamide riboside, isakhamzimba sokutya, ivithamin B3 eneziphumo kwimetabolism yamandla kunye ne-neuroprotection. I-Curr Opin Clin Nutr Metab Ukhathalelo. Ngo-2013 i-Nov; 16 (6): 657-61. doi: 10.1097 / MCO.0b013e32836510c0. Uphononongo. I-PubMed PMID: 24071780.
  • I-Bogan KL, i-Brenner C. I-Nicotinic acid, i-nicotinamide, kunye ne-nicotinamide riboside: Uvavanyo lweMoleki lweevithamini ze-NAD + zandulelayo kwisondlo somntu. Annu Rev Nutr. Ngo-2008; 28: 115-30. doi: 10.1146 / annurev.nutr.28.061807.155443. Uphononongo. I-PubMed PMID: 18429699.
  • I-Ghanta S, i-Grossmann RE, i-Brenner C. Mitochondrial protein acetylation njenge-cell-intrinsic, inguqu yokuqhuba yokugcinwa kwamafutha: i-metabolic kunye ne-metabolic logic ye-acetyl-lysine moditions. I-Crit Rev I-Biochem Mol Biol. Ngo-2013 i-Nov-Dec; 48 (6): 561-74. doi: 10.3109 / 10409238.2013.838204. Uphononongo. I-PubMed PMID: 24050258; I-PubMed Central PMCID: PMC4113336.
  • Yonke into ekufuneka uyazi ngeNicotinamide Riboside Chloride