UNicotinamide Riboside Chloride (NR) (23111-00-4) Umvelisi - uCofttek

INicotinamide Riboside Chloride (NR) (23111-00-4)

Aprili 7, 2020

I-Nikotinamide riboside, ekwabizwa ngokuba yi-NR kunye ne-SRT647, yindawo ye-pyridine-nucleoside ye-vithamini B3 esebenza njengomanduleli weNicotinamide adenine dinucleotide okanye NAD +. I-NR ibhloka ukungasebenzi kakuhle kweengcambu ze-dorsal root ganglion neurons ex kunye nokukhusela nxamnye nokulahleka kwendlebe okubangelwa yingxolo kwizimpuku eziphilayo.

 


Isimo: KwiMveliso yoLuntu
Iyunithi: 1kg / ingxowa, 25kg / Igubu

 

I-Nikotinamide Riboside Chloride (NR) (23111-00-4) ividiyo

 

INicotinamide Riboside Chloride (NR) Suqobo

igama: Nicotinamide Riboside chloride (NR)
CAS: 23111-00-4
Ukungcola 98%
Ifomula yeMolekyuli: C11H15ClN2O5
Ubunzima Ezinto: 290.7 g / mol
Melt Point: 115-125 ℃
Igama leKhemikhali: 3-carbamoyl-1-((3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium chloride
Iintetho: I-Nikotinamide riboside; I-SRT647; I-SRT-647; I-SRT 647; I-Nicotinamide Riboside Triflate, umxube we-α / β
InChI Key: IYABIFCKURFRPPO-FSDYPCQHSA-N
Ubomi obulicla: iiyure 2.7
Umzimba: I-soluble kwi-DMSO, Methanol, Amanzi
Umbandela woGcino: 0 - 4 C ixesha elifutshane (iintsuku ukuya kwiiveki), okanye -20 C ixesha elide (iinyanga)
isicelo: I-Nicotinamide riboside kuthiwa yimo entsha ye-pyridine-nucleoside yevithamini B₃ esebenza njengomanduleli weNicotinamide adenine dinucleotide okanye NAD +.
Kubonakala: Inikezelwe mhlophe kwiPalela yoMgubo

 

Yintoni uNicotinamide Riboside Chloride (NR) CAS 23111-00-4?

I-Nikotinamide riboside, ekwabizwa ngokuba yi-NR kunye ne-SRT647, yindawo ye-pyridine-nucleoside ye-vithamini B3 esebenza njengomanduleli weNicotinamide adenine dinucleotide okanye NAD +. I-NR ibhloka ukungasebenzi kakuhle kweengcambu ze-dorsal root ganglion neurons ex kunye nokukhusela nxamnye nokulahleka kwendlebe okubangelwa yingxolo kwizimpuku eziphilayo. I-Nikotinamide riboside ithintela umsipha, i-neural kunye ne-melanocyte stem cell senescence. Ukonyuka kokuvuselelwa kwemisipha kwiimpuku kuye kwaqwalaselwa emva konyango nge-nicotinamide riboside, ekhokelela ekuqikeleleni ukuba ingaphucula ukuphinda yenziwe kwamalungu afana nesibindi, izintso, nentliziyo. I-Nicotinamide riboside ikwehlisa neglucose egazini kunye nesibindi esinamafutha kwi-prediabetesic kunye nodidi lwe-2 yesifo seswekile ngelixa kuthintela ukukhula kwesifo se-neuropathy yeswekile. Qaphela: INicotinamide Riboside chloride ngumxube we-α / β.

 

 

Izibonelelo zeNicotinamide Riboside Chloride (NR) CAS 23111-00-4 izibonelelo

I-Nikotinamide nucleoside yindawo engaphambili kwe-nicotinamide adenine dinucleotide (NAD) kwaye imele umthombo wevithamini B3. Izifundo zamva nje zibonise ukuba ukuthatha inani elikhulu le-nicotinamide nucleosides yendalo ekhoyo ekutyeni kungabonelela ngezibonelelo ezintsha zempilo. Umzekelo, i-nicotinamide nucleoside iye yanyanzeliswa ukuba yandise uxinzelelo lwe-NAD ye-tishu kunye nokunyanzeliswa kwemvakalelo ye-insulin kunye nokwandisa umsebenzi we-sirtuin. Amandla ayo okwandisa ukuveliswa kwe-NAD ibonisa ukuba i-nicotinamide nucleosides inokuphucula impilo ye-mitochondrial, ivuselele umsebenzi we-mitochondrial, kunye nokukhuthaza ukuveliswa kwe-mitochondria entsha. Olunye uphando olusebenzisa i-nicotinamide nucleosides kwimodeli yesifo se-Alzheimer's luye lwabonisa ukuba imolekyuli ifumaneka ngendlela engqondo kwaye inokubonelela nge-neuroprotection ngokukhuthaza ubuchwephesha bengqondo be-NAD.

I-Nicotinamide Riboside Chloride nayo inokunciphisa ubunzima: Izifundo zibonise ukuba ngokwandisa amandla emetabolism, unokunciphisa ngempumelelo ukutya okunamafutha aphezulu okubangela ukuzuza komzimba. Ukuvavanya indlela ye-nicotinamide ribose yenkqubo ye-NR yokukhuthaza ukwehla kobunzima, abaphandi balinganise umsebenzi we-mitochondrial wesibindi onxulunyaniswa nokutya kwe-caloric, umsebenzi, iikhalori, isangqa sesinqe, ukuphumla kwenqanaba lokutya, ukwakheka komzimba, ukunyamezelana kweswekile, ubuntununtunu be-insulin kunye neendlela ezahlukeneyo ze-biochemical kunye ne-metabolism. iiparameter. Ezi datha kunye nendlela entsha yokulahleka kobunzima ngokusetyenziswa kwe-malabsorption, ukukhutshwa kweempawu zebhayiloji zokulandela umkhondo. Abaphandi baxela ukuba iimpuku ezondla izongezo ze-nicotinamide ze-nicotinamide zazinokwenzeka kakhulu ukuba zinciphise umzimba ngokunxulumene neempuku ezingakhange zongeze i-nicotinamide

 

 

INicotinamide Riboside Chloride (NR) CAS 23111-00-4 Indlela yokusebenza?

I-Nicotinamide Riboside Chloride (NR) ye-nucleosides ingaphambi kwe-nicotinamide adenine dinucleotide (NAD) kwaye imele umthombo wevithamini B3. Izifundo zamva nje zibonise ukuba ukuthatha isixa esikhulu se-nicotinamide nucleosides ngokwendalo ezikhoyo ekutyeni kunokubonelela ngezibonelelo ezitsha zempilo. Umzekelo, i-nicotinamide nucleosides iye yanyanzeliswa kukonyusa uxinzelelo lwe-NAD yeethishu kunye nokunciphisa ubuntununtunu be-insulin kunye nokwenza umsebenzi we-sirtuin. Amandla ayo okwandisa imveliso ye-NAD acebisa ukuba i-nicotinamide nucleosides nayo ingayiphucula impilo ye-mitochondrial, ivuselele umsebenzi we-mitochondrial, kwaye ikhuthaze ukuveliswa kwe-mitochondria entsha. Olunye uphononongo olusebenzisa i-nicotinamide nucleosides kwimodeli yesifo se-Alzheimer lubonise ukuba imolekyuli ayifumaneki kwingqondo kwaye inokubonelela nge-neuroprotection ngokukhuthaza ubuchopho be-NAD synthesis ..

 

 

INicotinamide Riboside Chloride (NR) CAS 23111-00-4 isicelo

Izifundo zangaphambili zibonakalise ukuba ukongezwa kwe-nicotinamide ribose akunakunyusa ngokukhuselekileyo amanqanaba e-NAD, kodwa kukwandisa ukusetyenziswa kwe-NAD + ebantwini, nto leyo engenakwenzeka nangenye i-Vitamin B3.Studies ibonise ukuba kanye i-nicotinamide ribose ivela kwiseli, umzimba uguqula ngokukhawuleza ube yi-NAD +. Ezi NAD + ke zivuselela inkqubo yokuqalisa kwe-intracellular yemveliso yamandla yi-mitochondria

I-Nicotinamide Riboside Chloride inokonyusa ukusebenza kwe-mitochondrial, eboniswe ukuba iphakamisa ukubonakaliswa kweeprotheni zemithambo ye-mitochondrial ye-protein, ukuphucula amandla e-membochondrial membrane, kunye nokunyusa izinga lokuphefumla kwe-oxidative kunye ne-intracellular ATP. Oku kunokuhamba kunye nenqanaba eliphezulu lokuvuselelwa ngokutsha kwe-mitochondrial. Umsebenzi we-Mitochondrial wehla njengoko sisaluphala, kwaye lo ngumqondiso wokuguga kweeseli esikufumanayo. I-NR inokunyusa ukusebenza kwe-mitochondria kunye nokuthintela i-senescence yeeseli ze-stem.

 

INicotinamide Riboside Chloride (NR) powder kwintengiso(Ungayithenga phi i-Nicotinamide Riboside Chloride (NR) powder ininzi)

Inkampani yethu iyonwabela ubudlelwane bexesha elide kunye nabaxumi bethu kuba sigxile kwinkonzo yabathengi kunye nokubonelela ngeemveliso ezintle. Ukuba unomdla kwimveliso yethu, siyaguquguquka ngendlela eqhelekileyo yokwenza ii-odolo ukuze zilungele iimfuno zakho ezithile kunye nexesha lethu elikhawulezayo lokufumana iiodolo uqinisekisa ukuba uyayiva imveliso yethu kwangexesha. Sijolise kwakhona kwiinkonzo ezongezwe ngexabiso. Sifumaneka kwimibuzo yenkonzo kunye nolwazi lokuxhasa ishishini lakho.

 

Sisebenza njenge-Nikotinamide Riboside Chloride (NR) umthengisi wempuphu iminyaka eliqela, sinikezela iimveliso ngexabiso lokukhuphisana, kwaye imveliso yethu ikumgangatho ophezulu kwaye iyavavanywa ngokungqongqo, ezimeleyo ukuze kuqinisekiswe ukuba ikhuselekile emhlabeni jikelele.

 

Ucaphulo

  • I-Chi Y, iSauve AA. I-Nicotinamide riboside, isakhamzimba sokutya, ivithamin B3 eneziphumo kwimetabolism yamandla kunye ne-neuroprotection. I-Curr Opin Clin Nutr Metab Ukhathalelo. Ngo-2013 i-Nov; 16 (6): 657-61. doi: 10.1097 / MCO.0b013e32836510c0. Uphononongo. I-PubMed PMID: 24071780.
  • I-Bogan KL, i-Brenner C. I-Nicotinic acid, i-nicotinamide, kunye ne-nicotinamide riboside: Uvavanyo lweMoleki lweevithamini ze-NAD + zandulelayo kwisondlo somntu. Annu Rev Nutr. Ngo-2008; 28: 115-30. doi: 10.1146 / annurev.nutr.28.061807.155443. Uphononongo. I-PubMed PMID: 18429699.
  • I-Ghanta S, i-Grossmann RE, i-Brenner C. Mitochondrial protein acetylation njenge-cell-intrinsic, inguqu yokuqhuba yokugcinwa kwamafutha: i-metabolic kunye ne-metabolic logic ye-acetyl-lysine moditions. I-Crit Rev I-Biochem Mol Biol. Ngo-2013 i-Nov-Dec; 48 (6): 561-74. doi: 10.3109 / 10409238.2013.838204. Uphononongo. I-PubMed PMID: 24050258; I-PubMed Central PMCID: PMC4113336.
  • Yonke into ekufuneka uyazi ngeNicotinamide Riboside Chloride