Vinpocetine (42971-09-5 factory umenzi mveliso

Vinpocetine

Novemba 5, 2020

I-Vinpocetine yi-alkaloid eyenziweyo evela kwisityalo se-periwinkle (ngakumbi, esidityaniswe kwimolekyuli eyaziwa ngokuba yi 'vincamine') ebonakala ngathi inerekhodi yokusetyenziswa kumazwe aseYurophu kunyango lokwehla kwengqondo, ukubuyela kwimeko yesiqhelo, kunye nokuxhuzula. IVinpocetine ikwasetyenziswa njengesixhobo se-nootropic ngethemba lokuba inokukhuthaza ukwakheka kwememori.

Isimo: KwiMveliso yoLuntu
Iyunithi: 1kg / ingxowa, 25kg / Igubu

Vinpocetine Suqobo

igama: Vinpocetine
CAS: 42971-09-5
Ukungcola 98%
Ifomula yeMolekyuli: C22H26N2O2
Ubunzima Ezinto: 350.454 g / mol
Melt Point: 147-149 ° C
Igama leKhemikhali: I-AY-27255, iCavinton, i-Eburnamenine-14-carboxylic acid, i-Ethyl Apovincaminate, i-Ethylapovincaminoate,
Iintetho: I-Ethyl Ester, i-RGH-4405, i-TCV-3b, iVinpocetin, iVinpocetina, iVinpocétine.
InChI Key: I-DDNCQMVWWZOMLN-IRLDBZIGSA-N
Ukupheliswa kwesiqingatha soBomi: I-2.54 +/- 0.48 iiyure
Umzimba: I-soluble kwi-DMSO, Methanol, Amanzi
Umbandela woGcino: 0 - 4 C ixesha elifutshane (iintsuku ukuya kwiiveki), okanye -20 C ixesha elide (iinyanga)
isicelo: IVinpocetine sisixhobo esivela kwisityalo sePeriwinkle esisetyenziswa njengesixhobo sokukhusela ingqondo nokuguga. Enye yezona ziqheleke kakhulu ze-nootropics, iVinpocetine inokuphucula ukuhamba kwegazi kwaye yenzelwe ukonyusa inkumbulo; eli bango lokugqibela alikhange liphandwe.
Kubonakala: Powder

 

Yintoni iVinpocetine (42971-09-5)?

I-Vinpocetine yi-alkaloid eyenziweyo evela kwisityalo se-periwinkle (ngakumbi, esidityaniswe kwimolekyuli eyaziwa ngokuba yi 'vincamine') ebonakala ngathi inerekhodi yokusetyenziswa kumazwe aseYurophu kunyango lokwehla kwengqondo, ukubuyela kwimeko yesiqhelo, kunye nokuxhuzula. IVinpocetine ikwasetyenziswa njengesixhobo se-nootropic ngethemba lokuba inokukhuthaza ukwakheka kwememori.

 

IVinpocetine (42971-09-5) izibonelelo

IVinpocetine ayifunxiswanga ngokupheleleyo, kodwa yintoni efunxwe ziincopho zegazi ngokukhawuleza kwaye ngokulula zingena kwingqondo apho zinokuthi zenze khona imisebenzi yazo. Iipropathi ezibonakala zisebenza kunyango lwe-vinpocetine yomlomo zibandakanya i-neuroprotection (ngokuchasene ne-toxins kunye nokukhuthaza okuthe kratya) kunye nokunciphisa ukudumba kwe-neural, ngelixa isiphumo sokuqaqanjelwa kwengqondo singabonakali ngathi sixhaswa bubungqina ngeli xesha. Ngelixa i-vinpocetine ibonakala iyasebenza ekuthinteleni i-toxins okanye uxinzelelo ekubangeleni i-amnesia, ayikaboniswa ukuba yendalo ukuphucula ukwakheka kwememori.

IVinpocetine ikwabonakala inefuthe elithile ngokuchasene nokwehla kwengqondo, kodwa inani loncwadi kwesi sihloko lingaphantsi kakhulu kunamanye amayeza avavanyelwe le njongo (i-CDP-Choline okanye i-Alpha-GPC ngokukodwa). Ubuncinane isifundo esinye siqaphele ukuphucuka kwexesha lokuphendula kunye ne-40mg ye-tablet ye-vinpocetine, enokuthi ibe yenye yezona zinto ziphuculweyo ezifanelekileyo kubantu abasempilweni ngalo mzuzu ngexesha.

Ukufakwa kwe-vinpocetine kubonakala kuphucula ukuhamba kwegazi ukuya kwingqondo ngaphandle kokuguqula uxinzelelo ngokwenkqubo, kwaye oku kucingelwa (kodwa kungaboniswa) ukufaka ukungenisa ngomlomo. Oku kunganciphisa iintloko ezibangelwa luxinzelelo olugqithisileyo, kwaye kuyahambelana nokusetyenziswa kwesiqhelo kwesityalo se-periwinkle (ukunciphisa iintloko).

 

IVinpocetine (42971-09-5) isicelo?

Iindlela zevinpocetine zininzi. Kubonakala ngathi iyanxibelelana neendlela ezininzi ze-ion (isodiyam, i-potassium, kunye ne-calcium) ngelixa ikhokelela kwiziphumo zokucinezelwa kokukhutshwa kwe-neurotransmitter kunye ne-neuroprotection xa i-dopamine okanye i-glutamate icinezelwa (ezi zimbini, xa zivuselelwa ngokungeyomfuneko ziityhefu, zinokubangela umonakalo we-oxidative). Ikwanxibelelana ne-alpha adrenergic receptors kunye ne-TPSO receptor, kwaye ngelixa isibonelelo ngqo sokunxibelelana kwe-receptor asicacanga ukuba kufanelekile kuba zisenzeka kugxininiso olufanayo olwenziwa kukunxibelelana kwejelo le-ion.

IVinpocetine ikwayiprosesa ye-PDE1 inhibitor, esisisixhobo esisebenza ngokubambisana kunye nokunyusa ukuqonda. Ngelishwa, olu thintelo lwenzeka ngethamo elikhulu ngokwaneleyo kwaye alunakusebenza kumgangatho wokuncedisa osemgangathweni wevinpocetine.

Ngokufana ne-PDE1, i-antidopaminergic enokubakho ye-vinpocetine kunye nokuthintela ngokuthe ngqo i-glutaminergic receptors zombini zibonakala zenzeka kwiindawo eziphezulu kakhulu kwi-vitro kwaye zinokungahambelani noncediso oluqhelekileyo.

 

IVinpocetine (42971-09-5) Isistim

I-Vinpocetine ithathwa kwinqanaba leedosi le-15-60mg yemihla ngemihla, yahlulwe yaziidosi ezintathu zemihla ngemihla kunye nokutya. Idosi esezantsi esemgangathweni yi-5mg kwisidlo ngasinye kwezi zintathu, nge-20mg kwisidlo ngasinye ibonwa njengesiphelo esifanelekileyo sokusebenza. Ezi dosi zithathwa ngeenjongo zokukhuselwa kwe-neuroprotection, ukuphucula ukuhamba kwegazi lobuchopho, kunye nokunciphisa izinga lokuhla kwengqondo.

Iidosi kwisiphelo esiphakamileyo solo luhlu (30-45mg iidosi ezibukhali) kunokuba luncedo ekukhuthazeni ukuqonda kunye nokwakheka kwememori kwabanye abantu abasempilweni, kodwa abukho ubungqina obuninzi obujonga eli bango.

Isilumkiso: kwabasetyhini abakhulelweyo, iidosi ezilinganayo kwi-10 mg / d zidityaniswe kwityhefu yomntwana kwizifundo zezilwanyana. I-10 mg / d inokuba yingozi, ngakumbi xa uthatha lonke ixesha lokukhulelwa.

 

Vinpocetine powder kwintengiso(Apho uthenge khona iVinpocetine powder ngesixa)

Inkampani yethu iyonwabela ubudlelwane bexesha elide kunye nabaxumi bethu kuba sigxile kwinkonzo yabathengi kunye nokubonelela ngeemveliso ezintle. Ukuba unomdla kwimveliso yethu, siyaguquguquka ngendlela eqhelekileyo yokwenza ii-odolo ukuze zilungele iimfuno zakho ezithile kunye nexesha lethu elikhawulezayo lokufumana iiodolo uqinisekisa ukuba uyayiva imveliso yethu kwangexesha. Sijolise kwakhona kwiinkonzo ezongezwe ngexabiso. Sifumaneka kwimibuzo yenkonzo kunye nolwazi lokuxhasa ishishini lakho.

Singumthengisi we-Vinpocetine ongumthengisi wempuphu kangangeminyaka eliqela, sibonelela ngexabiso elinokhuphiswano, kwaye imveliso yethu ikumgangatho ophezulu kwaye iyavavanywa ngokungqongqo nangokuzimeleyo ukuqinisekisa ukuba kukhuselekile ukusetyenziswa kwihlabathi liphela.

 

Ucaphulo
  1. UAbdel-Salam OME. I-Vinpocetine kunye ne-piracetam inefuthe le-antinociceptive kwimodeli yeentlungu ze-visceral kwiimpuku. IPhemacol Rep. 2006; 58 (5): 680-691.17085860
  2. I-Akopov SE, iGabrielian ES. Iziphumo zeasprini, dipyridamole, nifedipine kunye neCavinton ezisebenza ngokudityaniswa kweplatelet okubangelwa ziiarhente zokuhlanganisa zodwa kunye nokudibanisa. I-Eur J Clin Pharmacol. Ngo-1992; 42 (3): 257-259.1577042
  3. IAlkuraishy HM, Al-Gareeb AI, Albuhadilly AK. I-Vinpocetine kunye ne-pyritinol: imodeli entsha ye-rheological modulation yegazi kwizifo ze-cerebrovascular-isifundo sonyango esilawulwa ngokungahleliwe. Ucocekile kwi-Int Int. Ngo-2014; 2014: 324307.25548768.