α-ketoglutaric

ICofftek inamandla okuvelisa ngobuninzi kunye nokuhanjiswa kweCalcium 2-oxoglutarate kunye neAlfa-Ketoglutaric Acid phantsi kwemeko ye-cGMP.

Yintoni iAlpha-Ketoglutaric Acid (328-50-7)?

I-alpha-ketoglutaric acid yinto yebhayoloji efumaneka ngokwendalo emzimbeni womntu. Ikwafumaneka njengesongezelelo sokutya, i-alpha-ketoglutaric acid idlala indima ebalulekileyo kumjikelo weKrebs (uthotho lweempendulo zamachiza ezisetyenziselwa ukukhupha amandla agciniweyo). I-alpha-ketoglutaric acid supplements kuthiwa inikezela ngeendlela ezahlukeneyo zempilo, kubandakanya ukuphucula ukusebenza kweembaleki kunye nokuphucula imetabolism.

IAlfa-Ketoglutaric Acid (328-50-7) izibonelelo

Ngokutsho oko, izifundo ezimbalwa zakuqala zichaze izibonelelo ezinokubakho zokuncedisa i-alpha-ketoglutaric acid. Nalu olunye uphando olwenziweyo ngoku:
Isifo seZintso esinganyangekiyo
I-alpha-ketoglutaric acid isetyenzisiwe ukusukela ngasekupheleni kweminyaka yoo-1990 ukunceda ukwehla kunye nokufunxa iprotein kubantu abakwi-hemodialysis abafuna ukutya okuneprotein ephantsi. Ubungqina bamva nje bubonisa ukuba kunokulibazisa isidingo se-dialysis kubantu abanezifo ezingapheliyo zesifo sezintso (CKD). Ngokutsho kohlolisiso lowe-2017 kwiphephancwadi i-PLoS One, abaphandi bachonga balandela abantu abayi-1,483 abane-CKD ehambileyo abasebenzisa isongezo sealpha-ketoglutaric acid esibizwa ngokuba yiKetosteril. Ubungakanani bexesha lokulandelwa yayiyiminyaka eyi-1.57. Xa kuthelekiswa neseti ehambelanayo yabantu abangakhange bathathe isongezelelo, abo bakwenzileyo babengenamathuba okuba kufuneke idialysis yexesha elide. Izibonelelo zandiswa kuphela kwabo bathathe ngaphezulu kweepilisi ze-5.5 ngosuku, ezibonisa ukuba iimpembelelo zixhomekeke kwidosi. Ngaphandle kweziphumo ezilungileyo, akucaci ukuba yeyiphi indima edlalwa yi-alpha-ketoglutaric acid xa kuthelekiswa nezinye izithako ezisebenzayo. Uphando olongezelelweyo luyafuneka.

Impilo yamathumbu
I-alpha-ketoglutaric acid supplements kukholelwa ukuba yi-anticatabolic, oko kuthetha ukuba iyacothisa okanye iyathintela okanye ikhathabolism (ukonakala kwezicubu). Ngokwenkcazo, inkqubo ye-catabolic ichasene nenkqubo ye-anabolic (apho kwakhiwa khona izicwili). Uphononongo olwenziwe ngo-2012 kwiJenali ye-Animal Science yaxela ukuba i-alpha-ketoglutaric acid yathintela ukonakala kwamathumbu kwiigundane zelebhu ezondla ukutya okungenaziprotheni kangangeentsuku ezili-14. Endaweni yokufumana ukonakala kwivili-efana nevili yamathumbu-isiphumo esilindelweyo-iigundane ezondla i-alpha-ketoglutaric acid zazingenamonakalo ubonakalayo xa kuthelekiswa neempuku ezazingekho. Ngaphaya koko, iigundane zibonelele ngezongezo zikwazile ukugcina ukukhula okuqhelekileyo ngaphandle kokungabikho kweproteni. Iidosi eziphezulu zinikwe iziphumo ezingcono. Iziphumo zibonakala zixhasa i-alpha-ketoglutaric acid's anticatabolic. Ukongeza kwisicelo sayo kwizifo zezintso ezingapheliyo, i-alpha-ketoglutaric acid inokunceda abantu abane-toxemia yamathumbu kunye nokuphazamiseka kwe-malabsorption njengesifo se-celiac. Uphando olongezelelweyo luyafuneka.

UkuSebenza koBugcisa
Ngokwahlukileyo, iziphumo ze-alpha-ketoglutaric acid zibonakala zisilela xa zisetyenziselwa ukukhula kwemisipha kunye nokusebenza kwezemidlalo. Ngokophando lowe-2012 kwiJenali yoMbutho waMazwe ngaMazwe weSondlo sezeMidlalo, i-alpha-ketoglutaric acid ayinampembelelo ibonakalayo kumandla emisipha okanye ukunyamezelana kumadoda ayi-16 anikwe umsebenzi wokuzilolonga. Kolu phononongo, isiqingatha samadoda sanikwa i-3,000-milligrams (mg) ye-alpha-ketoglutaric acid, ngelixa esinye isiqingatha sanikwa i-placebo imizuzu engama-45 ngaphambi kokwenza umatshini wokushicilela webhentshi kunye nemithambo yokucinezela yomlenze. Kwiveki elandelayo, izongezo zafakwa, esinye nesiqingatha safumana esinye isiyobisi. Ukusebenza kwezemidlalo bekusekwe kumthamo womthwalo opheleleyo (i-TLV) yemithambo eyenziweyo ngokubambisene neqondo langaphambi nasemva kokuzilolonga kwentliziyo. Ezi zinto zifunyanisiweyo zibonisa ukungabikho kwempendulo ye-catabolic ayisiyonto ifanayo nempendulo ye-anabolic, ngakumbi phakathi kweembaleki.

Ialfa-Ketoglutaric Acid (328-50-7) isebenzisa?

Kutyando lwentliziyo, i-alpha-ketoglutaric acid ngamanye amaxesha ihanjiswa nge-intravenously (kwi-vein) ukunciphisa ukonakala kwimisipha yentliziyo ngenxa yokwehla kwegazi. Ukwenza njalo kunokuphucula ukuhamba kwegazi kwizintso emva kotyando. Ukusetyenziswa kwayo njengesongezelelo akuqinisekanga kangako. Abanye oogqirha bakholelwa ukuba i-alpha-ketoglutaric acid inokunyanga okanye ithintele iimeko ezahlukeneyo zempilo, kubandakanya:
  • Cataract
  • Izifo zesifo esingapheliyo
  • I-hepatomegaly (isibindi esandisiweyo)
  • I-toxemia yamathumbu emathunjini
  • I-thrush yomlomo
  • iOsteoporosis
  • UTendinopathy
  • Usulelo lwegwele
Ngenxa yendima yayo yokukhupha amandla agciniweyo, i-alpha-ketoglutaric acid ihlala ithengiswa njengesixhobo sokusebenza kwezemidlalo. Abanye abaxhasi bade bathi isongezelelo se-antioxidant sisiphumo sokunciphisa ukuguga. Njengokuba kuhlala kunjalo kwizongezo ezithi zinyange iimeko ezininzi ezingadibaniyo, ubungqina obuxhasa la mabango buthathaka. Ezinye, njengezixhobo zokuxhasa "ukuguga" (ngokusekwe ikakhulu kufundo luka-2014 olubandakanya iintshulube zematode), umda ongenakwenzeka.

I-Alpha-Ketoglutaric Acid (328-50-7) idosi

I-alpha-ketoglutaric acid supplements ziyafumaneka kwi-tablet, capsule, kunye ne-powder formulations kwaye inokufumaneka ngokulula kwi-intanethi okanye kwiivenkile ezijolise kwizongezo zokutya. Akukho zikhokelo kwindalo iphela zokusebenzisa ngokufanelekileyo i-alpha-ketoglutaric acid. Izongezo zihlala zithengiswa kumayeza aqala kwi-300 milligrams (mg) ukuya kwi-1,000 mg ethathwa kube kanye yonke imihla kunye okanye ngaphandle kokutya. Iidosi ukuya kuthi ga kwi-3,000 mg zisetyenzisiwe kwizifundo ngaphandle kweziphumo ezibi.

I-Alpha-Ketoglutaric Acid (328-50-7) enokwenzeka

I-alpha-ketoglutaric acid ithathwa njengekhuselekileyo kwaye inyamezeleka kakuhle. Izifundo eziphanda ngeziphumo zealpha-ketoglutaric acid zichaze iimpawu ezimbalwa ezimbi emva kweminyaka emithathu yokusetyenziswa. Njengekhompawundi eyenziwe kwii-amino acid ezingabalulekanga, i-alpha-ketoglutaric acid ayisiyonto onokuyisebenzisa ngokulula ngaphezulu. Nakuphi na ukugqithisa emzimbeni kuya kukhutshwa kumchamo okanye kuqhekezwe iibhloko ezisisiseko zeamino acid zezinye iinjongo. Ngale nto ithethwayo, ukhuseleko lwe-alpha-ketoglutaric acid kubafazi abakhulelweyo, oomama abangabongikazi, kunye nabantwana khange kusekwe. Oku kubandakanya abantwana abaneengxaki ezinqabileyo zemetabolism ezinje nge-alpha-ketoglutarate dehydrogenase defence (apho amanqanaba e-alpha-ketoglutaric acid ephakanyiswe ngokungaqhelekanga).

I-Alpha-Ketoglutaric Acid powder iyathengiswa (Apho ungathenga khona iAlpha-Ketoglutaric Acid powder ngesixa)

Inkampani yethu iyonwabela ubudlelwane bexesha elide kunye nabathengi bethu kuba sigxile kwinkonzo yabathengi kunye nokubonelela ngeemveliso ezintle. Ukuba unomdla kwimveliso yethu, siyabhetyebhetye ngokwezifiso iiodolo ukuze zilungele iimfuno zakho ezithile kunye nexesha lethu elikhawulezayo lokukhokelela kwii-odolo ziqinisekisa ukuba uya kuyingcamla kakhulu imveliso yethu ngexesha. Sijolise kwiinkonzo ezongezwe ngexabiso. Sifumaneka ngemibuzo yenkonzo kunye nolwazi ukuxhasa ishishini lakho. Singumthengisi we-Alpha-Ketoglutaric Acid powder umthengisi iminyaka eliqela, sibonelela ngexabiso elinokhuphiswano, kwaye imveliso yethu ikumgangatho ophezulu kwaye ivavanywa ngokungqongqo, nokuzimela ukuqinisekisa ukuba kukhuselekile ukusetyenziswa kwihlabathi liphela.

Imbekiselo:

  1. UAbrahams JP, uLeslie AG, uLutter R, u-Walker JE. Ulwakhiwo kwi-2.8 Isisombululo se-F1-ATPase esivela kwi-bovine heart mitochondria. Indalo. Ngo-1994; 370: 621-628. ikhonkco: 10.1038 / 370621a0.
  2. I-Alpers DH. I-Glutamine: ngaba idatha iyayixhasa unobangela wokuncediswa kwe-glutamine ebantwini? Gastroenterology. Ngo-2006; 130: S106 – S116. ikhonkco: 10.1053 / j.gastro.2005.11.049.
  3. UAshkanazi J, uCarpertier Y, uMichelsen C.Imisipha kunye neplasma amino acid kulandela ukwenzakala. UAnn Surg. Ngo-1980; 192: 78-85. ikhonkco: 10.1097 / 00000658-198007000-00014.