I-α-ketoglutaric (328-50-7) (71686-01-6) -Umzi mveliso womenzi

α-ketoglutaric

ICofftek inamandla okuvelisa ngobuninzi kunye nokuhanjiswa kweCalcium 2-oxoglutarate kunye neAlfa-Ketoglutaric Acid phantsi kwemeko ye-cGMP.

Isibhengezo saseCofttek

Thenga i-α-ketoglutaric powder

Yintoni iAlpha-Ketoglutaric Acid (328-50-7)?

I-alpha-ketoglutaric acid yinto yebhayoloji efumaneka ngokwendalo emzimbeni womntu. Ikwafumaneka njengesongezelelo sokutya, i-alpha-ketoglutaric acid idlala indima ebalulekileyo kumjikelo weKrebs (uthotho lweempendulo zamachiza ezisetyenziselwa ukukhupha amandla agciniweyo). I-alpha-ketoglutaric acid supplements kuthiwa inikezela ngeendlela ezahlukeneyo zempilo, kubandakanya ukuphucula ukusebenza kweembaleki kunye nokuphucula imetabolism.

IAlfa-Ketoglutaric Acid (328-50-7) izibonelelo

Ngokutsho oko, izifundo ezimbalwa zakuqala zichaze izibonelelo ezinokubakho zokuncedisa i-alpha-ketoglutaric acid. Nalu olunye uphando olwenziweyo ngoku:
Isifo seZintso esinganyangekiyo
I-Alpha-ketoglutaric acid isetyenziswe ukususela ekupheleni kwe-1990s ukunceda ukudiliza kunye nokufunxa iprotheni kubantu abakwi-hemodialysis abafuna ukutya okuphantsi kweeprotheyini. Ubungqina bamva nje bubonisa ukuba inokulibazisa imfuno ye-dialysis kubantu abanesifo sezintso ezingapheliyo (CKD).

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Umthombo othenjiweyo

I-PubMed Central

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Yiya kumthombo

Ngokophononongo luka-2017 kwijenali ye-PLoS One, abaphandi bachonga kwaye balandela abantu abayi-1,483 abane-CKD ephezulu abasebenzisa isongezelelo se-alpha-ketoglutaric acid ebizwa ngokuba yiKetosteril. Umyinge wexesha lokulandelwa kwakuyiminyaka eyi-1.57.
Xa kuthelekiswa neseti ehambelanayo yabantu abangazange bathathe isongezelelo, abo baye benzayo abafane bafune i-dialysis yexesha elide. Izibonelelo zandiswe kuphela kwabo bathatha ngaphezulu kweepilisi ze-5.5 ngosuku, ebonisa ukuba iziphumo zixhomekeke kwi-dose.
Ngaphandle kweziphumo ezilungileyo, akucaci ukuba yeyiphi indima ye-alpha-ketoglutaric acid xa kuthelekiswa nezinye izithako ezisebenzayo zesongezo. Uphando olongezelelweyo luyafuneka.

Impilo yamathumbu
I-Alpha-ketoglutaric acid supplements ikholelwa ukuba i-anticatabolic, oku kuthetha ukuba iyacotha okanye iyanqanda okanye i-catabolism (ukuchithwa kwezicubu). Ngenkcazo, inkqubo ye-catabolic ichasene nenkqubo ye-anabolic (apho izicubu zakhiwe).
Uphononongo lwe-2012 kwi-Italian Journal yeSayensi yeZilwanyana yabika ukuba i-alpha-ketoglutaric acid ithintele ukuphuka kwamathumbu kwiigundane zelebhu zondla ukutya okungenazo iiprotheyini kwiintsuku ze-14. Kunokuba ufumane umonakalo kwi-villi enjengomnwe wamathumbu-isiphumo esilindelekileyo-iigundane ezondla i-alpha-ketoglutaric acid zazingenawo umonakalo obonakalayo xa kuthelekiswa neempuku ezazingekho.
Ngaphezu koko, iigundane ezibonelele ngezongezelelo zakwazi ukugcina ukukhula okuqhelekileyo nangona ukungabikho okupheleleyo kweprotheni. Iidosi eziphezulu zinikezelwe kwiziphumo ezingcono nangakumbi.
Iziphumo zibonakala zixhasa iziphumo ze-alpha-ketoglutaric acid ye-anticatabolic. Ukongeza kwisicelo sayo kwisifo sezintso esingapheliyo, i-alpha-ketoglutaric acid inokunceda abantu abane-toxemia yamathumbu kunye nokuphazamiseka kwe-malabsorption njengesifo se-celiac. Uphando olongezelelweyo luyafuneka.

UkuSebenza koBugcisa
Ngokwahlukileyo, imiphumo ye-anticatabolic ye-alpha-ketoglutaric acid ibonakala iyancipha xa isetyenziselwa injongo yokukhula kwemisipha kunye nokusebenza kwezemidlalo.
Ngokophononongo lwe-2012 kwi-Journal ye-International Society of Sports Nutrition, i-alpha-ketoglutaric acid yayingenayo impembelelo ebonakalayo kumandla emisipha okanye ukunyamezela ukunyamezela kumadoda angama-16 anikwe umsebenzi wokuziqhelanisa noqeqesho lokumelana.

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Umthombo othenjiweyo

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Kolu phononongo, isiqingatha samadoda sanikwa i-3,000-milligrams (mg) ye-alpha-ketoglutaric acid, ngelixa esinye isiqingatha sanikwa indawo ye-45 imizuzu ngaphambi kokwenza i-bench press kunye ne-leg press exercises. Kwiveki elandelayo, izongezelelo zatshintshwa, isiqingatha ngasinye safumana ichiza elilelinye.
Ukusebenza kweembaleki kwakusekelwe kumthamo opheleleyo womthwalo (TLV) wokuzivocavoca owenziwe ngokuhambelana kunye namazinga entliziyo angaphambili nasemva kokuzivocavoca. Yintoni ezi ziphumo zibonisa ukungabikho kwempendulo ye-catabolic ayifani nempendulo ye-anabolic, ngakumbi phakathi kwabadlali.

Ialfa-Ketoglutaric Acid (328-50-7) isebenzisa?

Kwintliziyo yotyando, i-alpha-ketoglutaric acid ngamanye amaxesha ihanjiswa nge-intravenously (kwi-vein) ukunciphisa umonakalo kwimisipha yentliziyo ngenxa yokunciphisa ukuhamba kwegazi. Ukwenza njalo kunokuphucula ukuhamba kwegazi kwizintso emva kotyando.
Ukusetyenziswa kwayo njengesongezelelo akuqinisekanga kangako. Abanye oogqirha bakholelwa ukuba i-alpha-ketoglutaric acid inokunyanga okanye ukuthintela iimeko ezininzi zempilo, kuquka:
  • Cataract
  • Izifo zesifo esingapheliyo
  • I-hepatomegaly (isibindi esandisiweyo)
  • I-toxemia yamathumbu emathunjini
  • I-thrush yomlomo
  • iOsteoporosis
  • UTendinopathy
  • Usulelo lwegwele
Ngenxa yendima yayo ekukhupheni amandla agciniweyo, i-alpha-ketoglutaric acid ihlala ithengiswa njengesongezelelo sokusebenza kwezemidlalo. Abanye abaxhasi bade bathi i-supplement's antioxidant effect inokucothisa ukuguga.

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Umthombo othenjiweyo

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Njengoko kuhlala kunjalo ngezongezo ezithi zinyanga iimeko ezininzi ezingahambelaniyo, ubungqina obuxhasa la mabango bubuthathaka. Ezinye, njengeepropathi zesongezelelo "zokuthintela ukuguga" (ezisekwe kakhulu kuphononongo luka-2014 olubandakanya iintshulube zenematode), umda kwinto engenakwenzeka.

I-Alpha-Ketoglutaric Acid (328-50-7) idosi

I-Alpha-ketoglutaric acid izongezelelo ziyafumaneka kwithebhulethi, i-capsule, kunye ne-powder formulations kwaye inokufumaneka ngokulula kwi-intanethi okanye kwiivenkile ezikhethekileyo kwizongezo zokutya.
Akukho zikhokelo zendalo yonke zokusetyenziswa ngokufanelekileyo kwe-alpha-ketoglutaric acids. Izongezo zithengiswa ngokwesiqhelo kwiidosi ukusuka kwi-300 milligrams (mg) ukuya kwi-1,000 mg ethathwa kanye yonke imihla kunye okanye ngaphandle kokutya. Imilinganiselo ukuya kuthi ga kwi-3,000 mg isetyenziswe kwizifundo ezingenazo iziphumo ezibi.

I-Alpha-Ketoglutaric Acid (328-50-7) enokwenzeka

I-Alpha-ketoglutaric acid ithathwa njengekhuselekile kwaye inyamezeleke kakuhle. Izifundo eziphanda iziphumo ze-alpha-ketoglutaric acid zichaze iimpawu ezimbalwa ezimbi emva kweminyaka emithathu yokusetyenziswa.
Njengekhompawundi eyenziwe kwii-amino acids ezingabalulekanga, i-alpha-ketoglutaric acid ayisiyonto onokuthi ugqithise kuyo ngokulula. Nakuphi na ukugqithisa emzimbeni kuya kukhutshelwa kumchamo okanye kuqhekezwe kwiibhloko zokwakha ezisisiseko ze-amino acid ngezinye iinjongo.

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Umthombo othenjiweyo

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Yiya kumthombo

Ngaloo nto kuthiwa, ukhuseleko lwe-alpha-ketoglutaric acid kubasetyhini abakhulelweyo, oomama abahlengikazi kunye nabantwana ayikasekwa. Oku kubandakanya abantwana abaneengxaki zemetabolism ezinqabileyo ezifana nokusilela kwe-alpha-ketoglutarate dehydrogenase (apho amanqanaba e-alpha-ketoglutaric acid aphakanyisiwe ngokungaqhelekanga).

I-Alpha-Ketoglutaric Acid powder iyathengiswa (Apho ungathenga khona iAlpha-Ketoglutaric Acid powder ngesixa)

Inkampani yethu iyonwabela ubudlelwane bexesha elide kunye nabaxumi bethu kuba sigxile kwinkonzo yabathengi kunye nokubonelela ngeemveliso ezintle. Ukuba unomdla kwimveliso yethu, siyaguquguquka ngendlela eqhelekileyo yokwenza ii-odolo ukuze zilungele iimfuno zakho ezithile kunye nexesha lethu elikhawulezayo lokufumana iiodolo uqinisekisa ukuba uyayiva imveliso yethu kwangexesha. Sijolise kwakhona kwiinkonzo ezongezwe ngexabiso. Sifumaneka kwimibuzo yenkonzo kunye nolwazi lokuxhasa ishishini lakho.
Singomthengisi we-Alpha-Ketoglutaric Acid powder iminyaka eliqela, sibonelela ngeemveliso ngexabiso elikhuphisanayo, kwaye imveliso yethu ikumgangatho ophezulu kwaye ivavanywa ngokungqongqo, ngokuzimeleyo ukuqinisekisa ukuba ikhuselekile ukuba ingasetyenziswa kwihlabathi liphela.

Imbekiselo:

  1. UAbrahams JP, uLeslie AG, uLutter R, u-Walker JE. Ulwakhiwo kwi-2.8 Isisombululo se-F1-ATPase esivela kwi-bovine heart mitochondria. Indalo. Ngo-1994; 370: 621-628. ikhonkco: 10.1038 / 370621a0.
  2. I-Alpers DH. I-Glutamine: ngaba idatha iyayixhasa unobangela wokuncediswa kwe-glutamine ebantwini? Gastroenterology. Ngo-2006; 130: S106 – S116. ikhonkco: 10.1053 / j.gastro.2005.11.049.
  3. UAshkanazi J, uCarpertier Y, uMichelsen C.Imisipha kunye neplasma amino acid kulandela ukwenzakala. UAnn Surg. Ngo-1980; 192: 78-85. ikhonkco: 10.1097 / 00000658-198007000-00014.